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Protein

dITP/XTP pyrophosphatase

Gene

Lxx13570

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

XTP + H2O = XMP + diphosphate.UniRule annotation
dITP + H2O = dIMP + diphosphate.UniRule annotation
ITP + H2O = IMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Metal bindingi68MagnesiumUniRule annotation1
Binding sitei69Substrate; via amide nitrogenUniRule annotation1
Binding sitei174SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLXYL281090:G1G06-1391-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
dITP/XTP pyrophosphataseUniRule annotation (EC:3.6.1.66UniRule annotation)
Alternative name(s):
Non-canonical purine NTP pyrophosphataseUniRule annotation
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Ordered Locus Names:Lxx13570
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeLeifsonia
Proteomesi
  • UP000001306 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001781841 – 199dITP/XTP pyrophosphataseAdd BLAST199

Proteomic databases

PRIDEiQ6AEL0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi281090.Lxx13570

Structurei

3D structure databases

ProteinModelPortaliQ6AEL0
SMRiQ6AEL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 13Substrate bindingUniRule annotation6
Regioni151 – 154Substrate bindingUniRule annotation4
Regioni179 – 180Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108V82 Bacteria
COG0127 LUCA
HOGENOMiHOG000293319
KOiK02428
OMAiYDPIFQP
OrthoDBiPOG091H02BP

Family and domain databases

CDDicd00515 HAM1, 1 hit
Gene3Di3.90.950.10, 1 hit
HAMAPiMF_01405 Non_canon_purine_NTPase, 1 hit
InterProiView protein in InterPro
IPR020922 dITP/XTP_pyrophosphatase
IPR002637 Ham1p-like
IPR029001 ITPase-like_fam
PANTHERiPTHR11067 PTHR11067, 1 hit
PfamiView protein in Pfam
PF01725 Ham1p_like, 1 hit
SUPFAMiSSF52972 SSF52972, 1 hit
TIGRFAMsiTIGR00042 TIGR00042, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AEL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVVLATHN RNKALEFQQI LGDAVPGLQI VGYDGPEPVE DGITFEQNAL
60 70 80 90 100
IKARAAAERT GMIALADDSG ICVDAMGGAP GIFSARWAGR HGDAQANLRL
110 120 130 140 150
LLDQLADLPD SSRAAHFTAT LALVTPEGET TVVEGVWPGR IAREARGGHG
160 170 180 190
HGYDPIFLPD GHDVTAAELG PEAKNAESHR ARAFAAIVPV LRALSRPGN
Length:199
Mass (Da):20,967
Last modified:September 13, 2004 - v1
Checksum:iCB3B062B72FAD480
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA Translation: AAT89186.1
RefSeqiWP_011186180.1, NC_006087.1

Genome annotation databases

EnsemblBacteriaiAAT89186; AAT89186; Lxx13570
KEGGilxx:Lxx13570

Similar proteinsi

Entry informationi

Entry nameiIXTPA_LEIXX
AccessioniPrimary (citable) accession number: Q6AEL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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