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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:ctaDImported
Ordered Locus Names:Lxx15040Imported
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)Imported
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeLeifsonia
Proteomesi
  • UP000001306 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 44HelicalUniRule annotationAdd BLAST24
Transmembranei64 – 87HelicalUniRule annotationAdd BLAST24
Transmembranei107 – 132HelicalUniRule annotationAdd BLAST26
Transmembranei152 – 177HelicalUniRule annotationAdd BLAST26
Transmembranei189 – 217HelicalUniRule annotationAdd BLAST29
Transmembranei248 – 266HelicalUniRule annotationAdd BLAST19
Transmembranei278 – 297HelicalUniRule annotationAdd BLAST20
Transmembranei303 – 327HelicalUniRule annotationAdd BLAST25
Transmembranei339 – 361HelicalUniRule annotationAdd BLAST23
Transmembranei373 – 399HelicalUniRule annotationAdd BLAST27
Transmembranei411 – 433HelicalUniRule annotationAdd BLAST23
Transmembranei453 – 478HelicalUniRule annotationAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx15040

Structurei

3D structure databases

ProteinModelPortaliQ6AE84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 518COX1InterPro annotationAdd BLAST516

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085275
KOiK02274
OMAiMSFWLLP
OrthoDBiPOG091H042R

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AE84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKGNILVN YITSTDHKTI GYMYLISSFV YFLIGGVMAL IIRAQLFEPG
60 70 80 90 100
LQVVATKEQY NQLFTMHGTI MLLMFATPLF AGFANVLMPL QIGAPDVAFP
110 120 130 140 150
RLNALAYWFY SFGSLIAVAG FLTPQGAASF GWFAYAPLSS TTFSPGVGGN
160 170 180 190 200
LWVLGLGLSG FGTILGAVNF IITIITMRAP GMTMFRMPIF TWNTLVTSIL
210 220 230 240 250
VLMAFPVLAA AMFALAADRV FDAHIYDAAN GGALLWQHLF WFFGHPEVYI
260 270 280 290 300
IALPFFGIVS EIFPVFSRKP IFGYKTLIYA TIAIAALSIT VWAHHMYVTG
310 320 330 340 350
SVLLPWFSLM TMLIAVPTGV KIFNWIGTMW RGSLTFESPM LWSIGFLITF
360 370 380 390 400
TFGGLTGVIL ASPPLDFHVS DTYFVVAHFH YVVFGTVVFA MFAGFYFWWP
410 420 430 440 450
KWTGRMLNDR LGKWHFWLLF IGFHMTFLVQ HWLGVVGMPR RYATYLPSDG
460 470 480 490 500
FTWMNQLSSV GALLLAVSMI PFLVNVYLTA RHAPKVTVND PWGYSRSLEW
510 520 530 540 550
ATSCPPPRHN FTSIPRIRSE SPAFDLNHPE AGIPIGIGGG KDAPDTPVLD

LADNKVK
Length:557
Mass (Da):62,003
Last modified:September 13, 2004 - v1
Checksum:i6B7335AC27F904DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA Translation: AAT89312.1

Genome annotation databases

EnsemblBacteriaiAAT89312; AAT89312; Lxx15040
KEGGilxx:Lxx15040

Similar proteinsi

Entry informationi

Entry nameiQ6AE84_LEIXX
AccessioniPrimary (citable) accession number: Q6AE84
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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