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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1435-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:ctaDImported
Ordered Locus Names:Lxx15040Imported
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)Imported
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeLeifsonia
Proteomesi
  • UP000001306 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4424HelicalUniRule annotationAdd
BLAST
Transmembranei64 – 8724HelicalUniRule annotationAdd
BLAST
Transmembranei107 – 13226HelicalUniRule annotationAdd
BLAST
Transmembranei152 – 17726HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 21729HelicalUniRule annotationAdd
BLAST
Transmembranei248 – 26619HelicalUniRule annotationAdd
BLAST
Transmembranei278 – 29720HelicalUniRule annotationAdd
BLAST
Transmembranei303 – 32725HelicalUniRule annotationAdd
BLAST
Transmembranei339 – 36123HelicalUniRule annotationAdd
BLAST
Transmembranei373 – 39927HelicalUniRule annotationAdd
BLAST
Transmembranei411 – 43323HelicalUniRule annotationAdd
BLAST
Transmembranei453 – 47826HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx15040.

Structurei

3D structure databases

ProteinModelPortaliQ6AE84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 518516COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085275.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AE84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKGNILVN YITSTDHKTI GYMYLISSFV YFLIGGVMAL IIRAQLFEPG
60 70 80 90 100
LQVVATKEQY NQLFTMHGTI MLLMFATPLF AGFANVLMPL QIGAPDVAFP
110 120 130 140 150
RLNALAYWFY SFGSLIAVAG FLTPQGAASF GWFAYAPLSS TTFSPGVGGN
160 170 180 190 200
LWVLGLGLSG FGTILGAVNF IITIITMRAP GMTMFRMPIF TWNTLVTSIL
210 220 230 240 250
VLMAFPVLAA AMFALAADRV FDAHIYDAAN GGALLWQHLF WFFGHPEVYI
260 270 280 290 300
IALPFFGIVS EIFPVFSRKP IFGYKTLIYA TIAIAALSIT VWAHHMYVTG
310 320 330 340 350
SVLLPWFSLM TMLIAVPTGV KIFNWIGTMW RGSLTFESPM LWSIGFLITF
360 370 380 390 400
TFGGLTGVIL ASPPLDFHVS DTYFVVAHFH YVVFGTVVFA MFAGFYFWWP
410 420 430 440 450
KWTGRMLNDR LGKWHFWLLF IGFHMTFLVQ HWLGVVGMPR RYATYLPSDG
460 470 480 490 500
FTWMNQLSSV GALLLAVSMI PFLVNVYLTA RHAPKVTVND PWGYSRSLEW
510 520 530 540 550
ATSCPPPRHN FTSIPRIRSE SPAFDLNHPE AGIPIGIGGG KDAPDTPVLD

LADNKVK
Length:557
Mass (Da):62,003
Last modified:September 13, 2004 - v1
Checksum:i6B7335AC27F904DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89312.1.

Genome annotation databases

EnsemblBacteriaiAAT89312; AAT89312; Lxx15040.
KEGGilxx:Lxx15040.
PATRICi22336650. VBILeiXyl11655_1567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89312.1.

3D structure databases

ProteinModelPortaliQ6AE84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi281090.Lxx15040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT89312; AAT89312; Lxx15040.
KEGGilxx:Lxx15040.
PATRICi22336650. VBILeiXyl11655_1567.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085275.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiEOG6B35XR.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciLXYL281090:GH0X-1435-MONOMER.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07Imported.

Entry informationi

Entry nameiQ6AE84_LEIXX
AccessioniPrimary (citable) accession number: Q6AE84
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.