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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei240 – 2401SubstrateUniRule annotation
Metal bindingi262 – 2621ZincUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Active sitei331 – 3311Proton acceptorUniRule annotation
Active sitei332 – 3321Proton acceptorUniRule annotation
Binding sitei332 – 3321SubstrateUniRule annotation
Metal bindingi365 – 3651ZincUniRule annotation
Binding sitei365 – 3651SubstrateUniRule annotation
Binding sitei419 – 4191SubstrateUniRule annotation
Metal bindingi424 – 4241ZincUniRule annotation
Binding sitei424 – 4241SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1443-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Lxx15120
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenasePRO_0000135787Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx15120.

Structurei

3D structure databases

ProteinModelPortaliQ6AE76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AE76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTIDLRGVQ PTRTAFERLV PRPVVDVQAA MTVAADLIAD VRKRGAAALR
60 70 80 90 100
EQAERFDGGV PASVRVPVAE IVAAVDALPG GVREALEEAI ARVREATAAQ
110 120 130 140 150
VPPAAVTRIG PGAVIEQRWQ PVERAGLYVP GGKAVYPSSV VMNAVPAQVA
160 170 180 190 200
GVASIALASP PQREFGGAVH PTILGAAGLL GIDEVYAMGG AGAIGALAWG
210 220 230 240 250
VGELGLEPVQ VITGPGNIYV AAAKRVVRGQ TGIDSEAGTT EILVIADDTA
260 270 280 290 300
DPRYVAADLI SQAEHDEAAA SLLVTDSPAF VGRVAAELET LAASTRYAER
310 320 330 340 350
VRAALGGQQS AVVLVDDLDA AAAFSNAYGP EHLELQTADA EAVLARIQNA
360 370 380 390 400
GAIFVGPHAP VSLGDYLAGS NHVLPTGGQA RFSPGLGAYS FLRPQQVIRY
410 420 430
DREALRAVAG RIVALSGAED LSAHGEAVTL RFEERA
Length:436
Mass (Da):44,916
Last modified:September 13, 2004 - v1
Checksum:i5E0CE3756C5ED756
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89320.1.
RefSeqiYP_062425.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89320; AAT89320; Lxx15120.
GeneIDi2940014.
KEGGilxx:Lxx15120.
PATRICi22336666. VBILeiXyl11655_1575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89320.1.
RefSeqiYP_062425.1. NC_006087.1.

3D structure databases

ProteinModelPortaliQ6AE76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi281090.Lxx15120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT89320; AAT89320; Lxx15120.
GeneIDi2940014.
KEGGilxx:Lxx15120.
PATRICi22336666. VBILeiXyl11655_1575.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciLXYL281090:GH0X-1443-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiHISX_LEIXX
AccessioniPrimary (citable) accession number: Q6AE76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.