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Q6AE76

- HISX_LEIXX

UniProt

Q6AE76 - HISX_LEIXX

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei240 – 2401SubstrateUniRule annotation
    Metal bindingi262 – 2621ZincUniRule annotation
    Binding sitei262 – 2621SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Active sitei331 – 3311Proton acceptorUniRule annotation
    Active sitei332 – 3321Proton acceptorUniRule annotation
    Binding sitei332 – 3321SubstrateUniRule annotation
    Metal bindingi365 – 3651ZincUniRule annotation
    Binding sitei365 – 3651SubstrateUniRule annotation
    Binding sitei419 – 4191SubstrateUniRule annotation
    Metal bindingi424 – 4241ZincUniRule annotation
    Binding sitei424 – 4241SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciLXYL281090:GH0X-1443-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:Lxx15120
    OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
    Taxonomic identifieri281090 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
    ProteomesiUP000001306: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Histidinol dehydrogenasePRO_0000135787Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi281090.Lxx15120.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AE76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiDEMAMPI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AE76-1 [UniParc]FASTAAdd to Basket

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    MQTIDLRGVQ PTRTAFERLV PRPVVDVQAA MTVAADLIAD VRKRGAAALR    50
    EQAERFDGGV PASVRVPVAE IVAAVDALPG GVREALEEAI ARVREATAAQ 100
    VPPAAVTRIG PGAVIEQRWQ PVERAGLYVP GGKAVYPSSV VMNAVPAQVA 150
    GVASIALASP PQREFGGAVH PTILGAAGLL GIDEVYAMGG AGAIGALAWG 200
    VGELGLEPVQ VITGPGNIYV AAAKRVVRGQ TGIDSEAGTT EILVIADDTA 250
    DPRYVAADLI SQAEHDEAAA SLLVTDSPAF VGRVAAELET LAASTRYAER 300
    VRAALGGQQS AVVLVDDLDA AAAFSNAYGP EHLELQTADA EAVLARIQNA 350
    GAIFVGPHAP VSLGDYLAGS NHVLPTGGQA RFSPGLGAYS FLRPQQVIRY 400
    DREALRAVAG RIVALSGAED LSAHGEAVTL RFEERA 436
    Length:436
    Mass (Da):44,916
    Last modified:September 13, 2004 - v1
    Checksum:i5E0CE3756C5ED756
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89320.1.
    RefSeqiYP_062425.1. NC_006087.1.

    Genome annotation databases

    EnsemblBacteriaiAAT89320; AAT89320; Lxx15120.
    GeneIDi2940014.
    KEGGilxx:Lxx15120.
    PATRICi22336666. VBILeiXyl11655_1575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89320.1 .
    RefSeqi YP_062425.1. NC_006087.1.

    3D structure databases

    ProteinModelPortali Q6AE76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281090.Lxx15120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT89320 ; AAT89320 ; Lxx15120 .
    GeneIDi 2940014.
    KEGGi lxx:Lxx15120.
    PATRICi 22336666. VBILeiXyl11655_1575.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi DEMAMPI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci LXYL281090:GH0X-1443-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CTCB07.

    Entry informationi

    Entry nameiHISX_LEIXX
    AccessioniPrimary (citable) accession number: Q6AE76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3