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Q6AE76

- HISX_LEIXX

UniProt

Q6AE76 - HISX_LEIXX

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Protein
Histidinol dehydrogenase
Gene
hisD, Lxx15120
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei331 – 3311Proton acceptor By similarity
Active sitei332 – 3321Proton acceptor By similarity
Binding sitei332 – 3321Substrate By similarity
Metal bindingi365 – 3651Zinc By similarity
Binding sitei365 – 3651Substrate By similarity
Binding sitei419 – 4191Substrate By similarity
Metal bindingi424 – 4241Zinc By similarity
Binding sitei424 – 4241Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1443-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Lxx15120
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenaseUniRule annotation
PRO_0000135787Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx15120.

Structurei

3D structure databases

ProteinModelPortaliQ6AE76.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AE76-1 [UniParc]FASTAAdd to Basket

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MQTIDLRGVQ PTRTAFERLV PRPVVDVQAA MTVAADLIAD VRKRGAAALR    50
EQAERFDGGV PASVRVPVAE IVAAVDALPG GVREALEEAI ARVREATAAQ 100
VPPAAVTRIG PGAVIEQRWQ PVERAGLYVP GGKAVYPSSV VMNAVPAQVA 150
GVASIALASP PQREFGGAVH PTILGAAGLL GIDEVYAMGG AGAIGALAWG 200
VGELGLEPVQ VITGPGNIYV AAAKRVVRGQ TGIDSEAGTT EILVIADDTA 250
DPRYVAADLI SQAEHDEAAA SLLVTDSPAF VGRVAAELET LAASTRYAER 300
VRAALGGQQS AVVLVDDLDA AAAFSNAYGP EHLELQTADA EAVLARIQNA 350
GAIFVGPHAP VSLGDYLAGS NHVLPTGGQA RFSPGLGAYS FLRPQQVIRY 400
DREALRAVAG RIVALSGAED LSAHGEAVTL RFEERA 436
Length:436
Mass (Da):44,916
Last modified:September 13, 2004 - v1
Checksum:i5E0CE3756C5ED756
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89320.1.
RefSeqiYP_062425.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89320; AAT89320; Lxx15120.
GeneIDi2940014.
KEGGilxx:Lxx15120.
PATRICi22336666. VBILeiXyl11655_1575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89320.1 .
RefSeqi YP_062425.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6AE76.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx15120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT89320 ; AAT89320 ; Lxx15120 .
GeneIDi 2940014.
KEGGi lxx:Lxx15120.
PATRICi 22336666. VBILeiXyl11655_1575.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci LXYL281090:GH0X-1443-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiHISX_LEIXX
AccessioniPrimary (citable) accession number: Q6AE76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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