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Q6AE13

- HIS7_LEIXX

UniProt

Q6AE13 - HIS7_LEIXX

Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciLXYL281090:GH0X-1509-MONOMER.
    UniPathwayiUPA00031; UER00011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
    Short name:
    IGPDUniRule annotation
    Gene namesi
    Name:hisBUniRule annotation
    Ordered Locus Names:Lxx15850
    OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
    Taxonomic identifieri281090 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
    ProteomesiUP000001306: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Imidazoleglycerol-phosphate dehydratasePRO_0000158136Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi281090.Lxx15850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AE13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0131.
    HOGENOMiHOG000228064.
    KOiK01693.
    OMAiEDTAIVM.
    OrthoDBiEOG60PHGP.

    Family and domain databases

    HAMAPiMF_00076. HisB.
    InterProiIPR000807. ImidazoleglycerolP_deHydtase.
    IPR020565. ImidazoleglycerP_deHydtase_CS.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR23133:SF2. PTHR23133:SF2. 1 hit.
    PfamiPF00475. IGPD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 2 hits.
    PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
    PS00955. IGP_DEHYDRATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AE13-1 [UniParc]FASTAAdd to Basket

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    MTNRTASLRR ETSESGIELS LDLDGTGASE IHTSVPFYDH LLTAFAKHSL    50
    TDLRVRASGD TEIDVHHTVE DVGIVLGQAI RQALGDKAGL SRYGDALVPL 100
    DEALVQAVVD LSGRPYLVHA GEPSGFEFHL IGGHFTGSMV RHVFEAISFN 150
    AAITTHVTVV GGRDPHHIAE AEFKAFARAF RQAKAYDPLV SGIPSTKGAL 200
    Length:200
    Mass (Da):21,439
    Last modified:September 13, 2004 - v1
    Checksum:i37195935740BF884
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89383.1.
    RefSeqiWP_011186372.1. NC_006087.1.
    YP_062488.1. NC_006087.1.

    Genome annotation databases

    EnsemblBacteriaiAAT89383; AAT89383; Lxx15850.
    GeneIDi2940203.
    KEGGilxx:Lxx15850.
    PATRICi22336812. VBILeiXyl11655_1648.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89383.1 .
    RefSeqi WP_011186372.1. NC_006087.1.
    YP_062488.1. NC_006087.1.

    3D structure databases

    ProteinModelPortali Q6AE13.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281090.Lxx15850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT89383 ; AAT89383 ; Lxx15850 .
    GeneIDi 2940203.
    KEGGi lxx:Lxx15850.
    PATRICi 22336812. VBILeiXyl11655_1648.

    Phylogenomic databases

    eggNOGi COG0131.
    HOGENOMi HOG000228064.
    KOi K01693.
    OMAi EDTAIVM.
    OrthoDBi EOG60PHGP.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00011 .
    BioCyci LXYL281090:GH0X-1509-MONOMER.

    Family and domain databases

    HAMAPi MF_00076. HisB.
    InterProi IPR000807. ImidazoleglycerolP_deHydtase.
    IPR020565. ImidazoleglycerP_deHydtase_CS.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR23133:SF2. PTHR23133:SF2. 1 hit.
    Pfami PF00475. IGPD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 2 hits.
    PROSITEi PS00954. IGP_DEHYDRATASE_1. 1 hit.
    PS00955. IGP_DEHYDRATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CTCB07.

    Entry informationi

    Entry nameiHIS7_LEIXX
    AccessioniPrimary (citable) accession number: Q6AE13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3