Q6AE13 (HIS7_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Imidazoleglycerol-phosphate dehydratase
Short name=IGPD
EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	Lxx15850

Organism

Leifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]

Taxonomic identifier

281090 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia › Leifsonia xyli › Leifsonia xyli subsp. xyli

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00076.
Sequence similarities	Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076		PRO_0000158136

Sequences

	Sequence		Length	Mass (Da)
	Q6AE13 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 37195935740BF884	FASTA	200	21,439
	10 20 30 40 50 60 MTNRTASLRR ETSESGIELS LDLDGTGASE IHTSVPFYDH LLTAFAKHSL TDLRVRASGD 70 80 90 100 110 120 TEIDVHHTVE DVGIVLGQAI RQALGDKAGL SRYGDALVPL DEALVQAVVD LSGRPYLVHA 130 140 150 160 170 180 GEPSGFEFHL IGGHFTGSMV RHVFEAISFN AAITTHVTVV GGRDPHHIAE AEFKAFARAF 190 200 RQAKAYDPLV SGIPSTKGAL

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT89383.1.
RefSeq	YP_062488.1. NC_006087.1.
3D structure databases
ProteinModelPortal	Q6AE13.
ModBase	Search...
Protein-protein interaction databases
STRING	281090.Lxx15850.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT89383; AAT89383; Lxx15850.
GeneID	2940203.
KEGG	lxx:Lxx15850.
PATRIC	22336812. VBILeiXyl11655_1648.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
HOGENOM	HOG000228064.
KO	K01693.
OMA	STENVVH.
ProtClustDB	PRK00951.
Enzyme and pathway databases
BioCyc	LXYL281090:GH0X-1509-MONOMER.
UniPathway	UPA00031; UER00011.
Family and domain databases
HAMAP	MF_00076. HisB.
InterPro	IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfam	PF00475. IGPD. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_LEIXX

Accession

Primary (citable) accession number: Q6AE13

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	September 13, 2004
Last modified:	May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program