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Q6AE13 (HIS7_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Imidazoleglycerol-phosphate dehydratase

Short name=IGPD
EC=4.2.1.19
Gene names
Name:hisB
Ordered Locus Names:Lxx15850
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00076.

Sequence similarities

Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionimidazoleglycerol-phosphate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076
PRO_0000158136

Sequences

Sequence LengthMass (Da)Tools
Q6AE13 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 37195935740BF884

FASTA20021,439
        10         20         30         40         50         60 
MTNRTASLRR ETSESGIELS LDLDGTGASE IHTSVPFYDH LLTAFAKHSL TDLRVRASGD 

        70         80         90        100        110        120 
TEIDVHHTVE DVGIVLGQAI RQALGDKAGL SRYGDALVPL DEALVQAVVD LSGRPYLVHA 

       130        140        150        160        170        180 
GEPSGFEFHL IGGHFTGSMV RHVFEAISFN AAITTHVTVV GGRDPHHIAE AEFKAFARAF 

       190        200 
RQAKAYDPLV SGIPSTKGAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89383.1.
RefSeqYP_062488.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AE13.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx15850.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89383; AAT89383; Lxx15850.
GeneID2940203.
KEGGlxx:Lxx15850.
PATRIC22336812. VBILeiXyl11655_1648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0131.
HOGENOMHOG000228064.
KOK01693.
OMAHHIAESC.
OrthoDBEOG60PHGP.
ProtClustDBPRK00951.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1509-MONOMER.
UniPathwayUPA00031; UER00011.

Family and domain databases

HAMAPMF_00076. HisB.
InterProIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
PROSITEPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS7_LEIXX
AccessionPrimary (citable) accession number: Q6AE13
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways