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Q6ADP2 (ISPE_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Short name=CMK
EC=2.7.1.148
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene names
Name:ispE
Ordered Locus Names:Lxx17480
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3063064-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
PRO_0000189227

Regions

Nucleotide binding98 – 10811ATP Potential

Sites

Active site111 By similarity
Active site1401 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6ADP2 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 56A998FEE6A5F3CB

FASTA30631,415
        10         20         30         40         50         60 
MDAVHVRAPG KVNVFMRVGP LRHDGYHDVA TAYQALSLYE DVRAYPADDI SVTFAGGSVD 

        70         80         90        100        110        120 
TSALPTDGTN LAVKAAKLLA KRTGFTGGVR LEIDKRVPIA GGMGGGSADA AATLVACDAL 

       130        140        150        160        170        180 
WGTELGREEL LALAARLGAD VPFALVGGTA IGTGRGDRLS PALATGQFHW VLAFAEGQLS 

       190        200        210        220        230        240 
TPTVYSELDR HRERHASEIP PAQRAPGVDA GVLQALRAGD AAMLAEVLSN DLQAPAIHLA 

       250        260        270        280        290        300 
PSIAEVLELG ELNGALAGIV SGSGPTVAFL AADLDNALDV QIALSAARVR VVRATGPVHG 


ARVLSD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89504.1.
RefSeqYP_062609.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6ADP2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx17480.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89504; AAT89504; Lxx17480.
GeneID2940425.
KEGGlxx:Lxx17480.
PATRIC22337164. VBILeiXyl11655_1822.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1947.
HOGENOMHOG000019600.
KOK00919.
OMAEGYHPIS.
OrthoDBEOG62VNQ2.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1656-MONOMER.
UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPE_LEIXX
AccessionPrimary (citable) accession number: Q6ADP2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways