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Q6AD62 (PUR9_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Lxx19650
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192098

Sequences

Sequence LengthMass (Da)Tools
Q6AD62 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: F844E5A1C3FFCDBA

FASTA52655,076
        10         20         30         40         50         60 
MNGPRHDTSL FRERDVVPIR RALISVSDKT GLLDLAASLA DAGVEIVSTG STAQTIREAG 

        70         80         90        100        110        120 
HTVTDVASVT GFPESLDGRV KTLHPAIHSG LLADLRLASH EEQLKDLGIE PFELVVVNLY 

       130        140        150        160        170        180 
PFVETVASGA VDDDVVEQID IGGPAMVRAS AKNHANVAIV VSPADYAGLA AAVAAGGTTW 

       190        200        210        220        230        240 
GQRRELAARA FAHTAAYDGA VAAWFAGEAP DLSAVAERFE VRAEWGQPLR YGENAHQAAA 

       250        260        270        280        290        300 
LYADPAGCGI AQASQHGGKE MSYNNYVDAD AALRSAYDFA EPAVAIVKHA NPCGIAVAGD 

       310        320        330        340        350        360 
IAEAHRKAHE CDPVSAYGGV IAANRTVTLA MAETVRGIFT EVLIAPGYEP GALELLKTKK 

       370        380        390        400        410        420 
NLRILELPVG YARSLTEFRQ ISGGVLVQDT DRFDEFDSSG WTLVAGAEAD AVTRADLEFT 

       430        440        450        460        470        480 
WKACRAVKSN AILLAKDGAS VGVGMGQVNR VDSCTLAVSR AAERAVGAVA ASDAFFPFAD 

       490        500        510        520 
GPEILIAAGV AAIVQPGGSI RDEEVIASAT AAGVTMYFTG ERHFFH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89682.1.
RefSeqYP_062787.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AD62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx19650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89682; AAT89682; Lxx19650.
GeneID2939833.
KEGGlxx:Lxx19650.
PATRIC22337604. VBILeiXyl11655_2039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMAHRRAHAC.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1854-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LEIXX
AccessionPrimary (citable) accession number: Q6AD62
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways