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Q6AD62

- PUR9_LEIXX

UniProt

Q6AD62 - PUR9_LEIXX

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Lxx19650
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1854-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Lxx19650
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_0000192098Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx19650.

Structurei

3D structure databases

ProteinModelPortaliQ6AD62.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AD62-1 [UniParc]FASTAAdd to Basket

« Hide

MNGPRHDTSL FRERDVVPIR RALISVSDKT GLLDLAASLA DAGVEIVSTG    50
STAQTIREAG HTVTDVASVT GFPESLDGRV KTLHPAIHSG LLADLRLASH 100
EEQLKDLGIE PFELVVVNLY PFVETVASGA VDDDVVEQID IGGPAMVRAS 150
AKNHANVAIV VSPADYAGLA AAVAAGGTTW GQRRELAARA FAHTAAYDGA 200
VAAWFAGEAP DLSAVAERFE VRAEWGQPLR YGENAHQAAA LYADPAGCGI 250
AQASQHGGKE MSYNNYVDAD AALRSAYDFA EPAVAIVKHA NPCGIAVAGD 300
IAEAHRKAHE CDPVSAYGGV IAANRTVTLA MAETVRGIFT EVLIAPGYEP 350
GALELLKTKK NLRILELPVG YARSLTEFRQ ISGGVLVQDT DRFDEFDSSG 400
WTLVAGAEAD AVTRADLEFT WKACRAVKSN AILLAKDGAS VGVGMGQVNR 450
VDSCTLAVSR AAERAVGAVA ASDAFFPFAD GPEILIAAGV AAIVQPGGSI 500
RDEEVIASAT AAGVTMYFTG ERHFFH 526
Length:526
Mass (Da):55,076
Last modified:September 13, 2004 - v1
Checksum:iF844E5A1C3FFCDBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89682.1.
RefSeqiWP_011186668.1. NC_006087.1.
YP_062787.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89682; AAT89682; Lxx19650.
GeneIDi2939833.
KEGGilxx:Lxx19650.
PATRICi22337604. VBILeiXyl11655_2039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89682.1 .
RefSeqi WP_011186668.1. NC_006087.1.
YP_062787.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6AD62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx19650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT89682 ; AAT89682 ; Lxx19650 .
GeneIDi 2939833.
KEGGi lxx:Lxx19650.
PATRICi 22337604. VBILeiXyl11655_2039.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LXYL281090:GH0X-1854-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiPUR9_LEIXX
AccessioniPrimary (citable) accession number: Q6AD62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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