Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei611For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Lxx19980
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeLeifsonia
Proteomesi
  • UP000001306 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353482 – 616Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST615

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi281090.Lxx19980.

Structurei

3D structure databases

ProteinModelPortaliQ6AD32.
SMRiQ6AD32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 221Glutamine amidotransferase type-2UniRule annotationAdd BLAST220
Domaini288 – 428SIS 1UniRule annotationAdd BLAST141
Domaini461 – 606SIS 2UniRule annotationAdd BLAST146

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiGTSHYAG.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AD32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYVGT DKSLEVLLGG LKRLEYRGYD SAGIAVIAPD GSLATAKRAG
60 70 80 90 100
KLDVLTDELQ QHPIPDGGTG IGHTRWATHG GPTDCNAHPH LGDDGRLAVI
110 120 130 140 150
HNGIIENFAT LRDELLAEEF TFESETDTEV AAVLLGREYR AAGSLSEAFQ
160 170 180 190 200
RVVSRLEGAF TLLALHQDQP HVVVGARRNS PLVIGLGEGE NFLGSDVAAF
210 220 230 240 250
VEHTQRALAI GQDQIVTITP EQVTVTDFAG APVEVEPFDV AWDATAAEKG
260 270 280 290 300
GWPSFMAKEI AEEPDAVANT LRGRAADGAV HIPELDALGD EFFLGIDQIT
310 320 330 340 350
IVACGTAAYA GLVGSYAIEK WARVPVTVEL SHEFRYREPV ISGGTLIVSI
360 370 380 390 400
SQSGETMDTL MAVKYAREAG AKAISVCNTQ GATIPRESDA ALYTHAGPEV
410 420 430 440 450
AVASTKAFVG QIAALYLFGL SLARVRGTLS AAQQRDAVAE LFAVPEKIRA
460 470 480 490 500
VLESKDTIAQ LAHWMSDTRS VLFLGRHVGY PIALEGALKL KELAYIHAEG
510 520 530 540 550
FAAGELKHGP IALIEPGQPV FVVVPSPRWS DELHKKVVSN IQEIRARGAR
560 570 580 590 600
VIAIAEAGDA AVLPFADEVI RIPLAAPLFE PLLSVIPLQI FAMELAVAKG
610
LDVDQPRNLA KSVTVE
Length:616
Mass (Da):65,561
Last modified:January 23, 2007 - v3
Checksum:i8E3F2B7308706BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89712.1.
RefSeqiWP_011186698.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89712; AAT89712; Lxx19980.
KEGGilxx:Lxx19980.

Similar proteinsi

Entry informationi

Entry nameiGLMS_LEIXX
AccessioniPrimary (citable) accession number: Q6AD32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome