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Q6AD32

- GLMS_LEIXX

UniProt

Q6AD32 - GLMS_LEIXX

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, Lxx19980
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei611 – 6111For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1884-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:Lxx19980
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 616615Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135348Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi281090.Lxx19980.

Structurei

3D structure databases

ProteinModelPortaliQ6AD32.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 221220Glutamine amidotransferase type-2
Add
BLAST
Domaini288 – 428141SIS 1
Add
BLAST
Domaini461 – 606146SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiNTPVERE.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AD32-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYVGT DKSLEVLLGG LKRLEYRGYD SAGIAVIAPD GSLATAKRAG    50
KLDVLTDELQ QHPIPDGGTG IGHTRWATHG GPTDCNAHPH LGDDGRLAVI 100
HNGIIENFAT LRDELLAEEF TFESETDTEV AAVLLGREYR AAGSLSEAFQ 150
RVVSRLEGAF TLLALHQDQP HVVVGARRNS PLVIGLGEGE NFLGSDVAAF 200
VEHTQRALAI GQDQIVTITP EQVTVTDFAG APVEVEPFDV AWDATAAEKG 250
GWPSFMAKEI AEEPDAVANT LRGRAADGAV HIPELDALGD EFFLGIDQIT 300
IVACGTAAYA GLVGSYAIEK WARVPVTVEL SHEFRYREPV ISGGTLIVSI 350
SQSGETMDTL MAVKYAREAG AKAISVCNTQ GATIPRESDA ALYTHAGPEV 400
AVASTKAFVG QIAALYLFGL SLARVRGTLS AAQQRDAVAE LFAVPEKIRA 450
VLESKDTIAQ LAHWMSDTRS VLFLGRHVGY PIALEGALKL KELAYIHAEG 500
FAAGELKHGP IALIEPGQPV FVVVPSPRWS DELHKKVVSN IQEIRARGAR 550
VIAIAEAGDA AVLPFADEVI RIPLAAPLFE PLLSVIPLQI FAMELAVAKG 600
LDVDQPRNLA KSVTVE 616
Length:616
Mass (Da):65,561
Last modified:January 23, 2007 - v3
Checksum:i8E3F2B7308706BAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89712.1.
RefSeqiWP_011186698.1. NC_006087.1.
YP_062817.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89712; AAT89712; Lxx19980.
GeneIDi2939821.
KEGGilxx:Lxx19980.
PATRICi22337670. VBILeiXyl11655_2072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89712.1 .
RefSeqi WP_011186698.1. NC_006087.1.
YP_062817.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6AD32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx19980.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT89712 ; AAT89712 ; Lxx19980 .
GeneIDi 2939821.
KEGGi lxx:Lxx19980.
PATRICi 22337670. VBILeiXyl11655_2072.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi NTPVERE.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci LXYL281090:GH0X-1884-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiGLMS_LEIXX
AccessioniPrimary (citable) accession number: Q6AD32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi