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Q6AD32

- GLMS_LEIXX

UniProt

Q6AD32 - GLMS_LEIXX

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei611 – 6111For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciLXYL281090:GH0X-1884-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:Lxx19980
    OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
    Taxonomic identifieri281090 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
    ProteomesiUP000001306: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 616615Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135348Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi281090.Lxx19980.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AD32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 221220Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini288 – 428141SIS 1UniRule annotationAdd
    BLAST
    Domaini461 – 606146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiNTPVERE.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AD32-1 [UniParc]FASTAAdd to Basket

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    MCGIVGYVGT DKSLEVLLGG LKRLEYRGYD SAGIAVIAPD GSLATAKRAG    50
    KLDVLTDELQ QHPIPDGGTG IGHTRWATHG GPTDCNAHPH LGDDGRLAVI 100
    HNGIIENFAT LRDELLAEEF TFESETDTEV AAVLLGREYR AAGSLSEAFQ 150
    RVVSRLEGAF TLLALHQDQP HVVVGARRNS PLVIGLGEGE NFLGSDVAAF 200
    VEHTQRALAI GQDQIVTITP EQVTVTDFAG APVEVEPFDV AWDATAAEKG 250
    GWPSFMAKEI AEEPDAVANT LRGRAADGAV HIPELDALGD EFFLGIDQIT 300
    IVACGTAAYA GLVGSYAIEK WARVPVTVEL SHEFRYREPV ISGGTLIVSI 350
    SQSGETMDTL MAVKYAREAG AKAISVCNTQ GATIPRESDA ALYTHAGPEV 400
    AVASTKAFVG QIAALYLFGL SLARVRGTLS AAQQRDAVAE LFAVPEKIRA 450
    VLESKDTIAQ LAHWMSDTRS VLFLGRHVGY PIALEGALKL KELAYIHAEG 500
    FAAGELKHGP IALIEPGQPV FVVVPSPRWS DELHKKVVSN IQEIRARGAR 550
    VIAIAEAGDA AVLPFADEVI RIPLAAPLFE PLLSVIPLQI FAMELAVAKG 600
    LDVDQPRNLA KSVTVE 616
    Length:616
    Mass (Da):65,561
    Last modified:January 23, 2007 - v3
    Checksum:i8E3F2B7308706BAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89712.1.
    RefSeqiWP_011186698.1. NC_006087.1.
    YP_062817.1. NC_006087.1.

    Genome annotation databases

    EnsemblBacteriaiAAT89712; AAT89712; Lxx19980.
    GeneIDi2939821.
    KEGGilxx:Lxx19980.
    PATRICi22337670. VBILeiXyl11655_2072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89712.1 .
    RefSeqi WP_011186698.1. NC_006087.1.
    YP_062817.1. NC_006087.1.

    3D structure databases

    ProteinModelPortali Q6AD32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281090.Lxx19980.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT89712 ; AAT89712 ; Lxx19980 .
    GeneIDi 2939821.
    KEGGi lxx:Lxx19980.
    PATRICi 22337670. VBILeiXyl11655_2072.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi NTPVERE.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci LXYL281090:GH0X-1884-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CTCB07.

    Entry informationi

    Entry nameiGLMS_LEIXX
    AccessioniPrimary (citable) accession number: Q6AD32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3