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Q6ACQ8

- PANC_LEIXX

UniProt

Q6ACQ8 - PANC_LEIXX

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Protein
Pantothenate synthetase
Gene
panC, Lxx21410
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton donor By similarity
Binding sitei68 – 681Beta-alanine By similarity
Binding sitei68 – 681Pantoate By similarity
Binding sitei160 – 1601Pantoate By similarity
Binding sitei183 – 1831ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATP By similarity
Nucleotide bindingi154 – 1574ATP By similarity
Nucleotide bindingi191 – 1944ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-2018-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Lxx21410
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Pantothenate synthetaseUniRule annotation
PRO_0000305471Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi281090.Lxx21410.

Structurei

3D structure databases

ProteinModelPortaliQ6ACQ8.
SMRiQ6ACQ8. Positions 29-287.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ACQ8-1 [UniParc]FASTAAdd to Basket

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MTVIACLREI LSTARRTAVA EGASDAPASR VVLVPTMGAL HEGHVRLVNH    50
ARDLGGIVVV SIFVNPLQFG PGEDLDRYPR TLDADVALLD GLADVVFAPA 100
AAEMYPQGES STRVTAGAVG GLFEGASRPG HFDGMLTVVA KLFGIAQPDV 150
AVFGQKDAQQ VHLVGRMVDD LNLPVTIAVV DTVREPDGLA LSSRNRYLDA 200
DARAAAATLS RALADGVAAC AGGAAAVLTA ARVRVEAEPV VRLDYLVIVD 250
QGTFREVAPN YHGPAFLLIA ARVGSTRLID NERITLP 287
Length:287
Mass (Da):30,061
Last modified:September 13, 2004 - v1
Checksum:i49320EEA1D496D80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89835.1.
RefSeqiWP_011186819.1. NC_006087.1.
YP_062940.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89835; AAT89835; Lxx21410.
GeneIDi2940613.
KEGGilxx:Lxx21410.
PATRICi22337974. VBILeiXyl11655_2223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89835.1 .
RefSeqi WP_011186819.1. NC_006087.1.
YP_062940.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6ACQ8.
SMRi Q6ACQ8. Positions 29-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx21410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT89835 ; AAT89835 ; Lxx21410 .
GeneIDi 2940613.
KEGGi lxx:Lxx21410.
PATRICi 22337974. VBILeiXyl11655_2223.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci LXYL281090:GH0X-2018-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiPANC_LEIXX
AccessioniPrimary (citable) accession number: Q6ACQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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