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Q6ACQ1 (GCH1_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:Lxx21490
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119416

Sites

Metal binding801Zinc By similarity
Metal binding831Zinc By similarity
Metal binding1511Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6ACQ1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 22E41CFBF5A2D837

FASTA19119,874
        10         20         30         40         50         60 
MTGFDRARIE AAVAEILAAV GEDPSRPGLS ATPSRVADAY AEFFAGLGRD AEAELGEPVP 

        70         80         90        100        110        120 
LEQGQAETVI LREISFRSVC EHHLLPFIGV AHVAYLPGEA VIGLGRIPRV IDTLAARPQV 

       130        140        150        160        170        180 
QERLTEQIAD TFEAGAGARG VLVVLSAEHG CVTARGPRQV AATTVTLAAR GEFAEPAARA 

       190 
ELIALIGCGA A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89842.1.
RefSeqYP_062947.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6ACQ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx21490.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89842; AAT89842; Lxx21490.
GeneID2939497.
KEGGlxx:Lxx21490.
PATRIC22337990. VBILeiXyl11655_2231.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAYEQIEYA.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-2025-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_LEIXX
AccessionPrimary (citable) accession number: Q6ACQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways