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Q6ACE6 (PUR2_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:Lxx22780
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151457

Regions

Domain108 – 307200ATP-grasp
Nucleotide binding134 – 18855ATP By similarity

Sites

Metal binding2771Magnesium or manganese By similarity
Metal binding2791Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6ACE6 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 2A0F80CE0B2456C5

FASTA41743,135
        10         20         30         40         50         60 
MKILVLGSGA REHAIITALL AERAGHDIVA APGNAGIAAD VAVEPGLDTL NGAAVTAFAI 

        70         80         90        100        110        120 
ENGFELVVIG PEAPLVAGVA DPLRRRGIPV FGPGRAAAQL EGSKTFAKRI MDEAGVPTGR 

       130        140        150        160        170        180 
AVRAATLAEA GSALDEFGAP YVVKADGLAA GKGVIVTEDR AAALAHAARY LTHGSVLVEE 

       190        200        210        220        230        240 
FLDGEEVSLF LVSDGHTVLP LSPAQDYKRL LDGDAGPNTG GMGAYSPLTW LPETFVDEVI 

       250        260        270        280        290        300 
DTVAMPTVRQ LAAEQTPFIG LLYCGLIVTA KGIRVIEFNA RFGDPETQVV LPRLVTPLST 

       310        320        330        340        350        360 
LLFAAATGTL SGMPRPEFAP GTTVTVVLAS EDYPESPRTG RPIAGLDEAA SVPEVTIAHA 

       370        380        390        400        410 
STARDETTGA LLATGGRVLS VVARGATFAD ARTRAYDALS RIRLDGSQYR TDIAARA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89947.1.
RefSeqYP_063052.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6ACE6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx22780.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89947; AAT89947; Lxx22780.
GeneID2939853.
KEGGlxx:Lxx22780.
PATRIC22338318. VBILeiXyl11655_2392.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMADPEAMNV.
OrthoDBEOG69SKD1.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-2149-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_LEIXX
AccessionPrimary (citable) accession number: Q6ACE6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways