Q6AC27 (IOLG_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Lxx24320

Organism

Leifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]

Taxonomic identifier

281090 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352574

Sequences

	Sequence		Length	Mass (Da)
	Q6AC27 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: B2C2B50874FB1C9C	FASTA	339	36,423
	10 20 30 40 50 60 MTTTPDLRVG VGGAGQMGAD HIQRITRVIS GATVSAIVEP DAGRAAAAAA APGSRAFASL 70 80 90 100 110 120 DDALDASALE AVVIATPGQF HELVLVPALA AGLPVLCEKP LTPDSAEALR VLELEQTLDR 130 140 150 160 170 180 PHIQLGFMRR FDDEYRALRE LVVSGDAGEL LFLRGVHRNP SVPESYTQSM LITDSVVHEF 190 200 210 220 230 240 DVMPWLAGSP VASVEVKYPR RNDRAPERLR EPILVLIELR NGVLVDVEMN VSVRFGYQVA 250 260 270 280 290 300 TEAVFQTGTA RIGQPAGLQR WSDARFSIAE HTSFTTRFAR AYDAQVQAWV DAVRDGSLVA 310 320 330 GPNAWDGYLV ALACEAGVRA LSEPGPIAFA PAERPAFYA

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed: 15305603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT90065.1.
RefSeq	YP_063170.1. NC_006087.1.
3D structure databases
ProteinModelPortal	Q6AC27.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2939273.
GenomeReviews	Gene locus Lxx24320 in contig AE016822_GR.
KEGG	lxx:Lxx24320.
NMPDR	fig|281090.3.peg.1957.
PATRIC	22338634. VBILeiXyl11655_2549.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG612336.
OMA	HESINNA.
ProtClustDB	CLSK632711.
Enzyme and pathway databases
BioCyc	LXYL281090:LXX24320-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_LEIXX

Accession

Primary (citable) accession number: Q6AC27

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program