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Q6ABX9

- ODP2_LEIXX

UniProt

Q6ABX9 - ODP2_LEIXX

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Protein

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Cofactori

(R)-lipoateBy similarityNote: Binds 1 lipoyl cofactor covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei425 – 4251Sequence Analysis

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-2349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC:2.3.1.12)
Alternative name(s):
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
E2
Gene namesi
Name:pdhC
Ordered Locus Names:Lxx25050
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complexPRO_0000232458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-lipoyllysineBy similarityPROSITE-ProRule annotation

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.By similarity

Protein-protein interaction databases

STRINGi281090.Lxx25050.

Structurei

3D structure databases

ProteinModelPortaliQ6ABX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7876Lipoyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.Curated
Contains 1 lipoyl-binding domain.CuratedPROSITE-ProRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281564.
KOiK00627.
OMAiTIKQKPW.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ABX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRESQFLLPD VGEGLTEAEI VSWKVAPGDS VAVNQVIVEI ETAKSLVELP
60 70 80 90 100
SPFEGTVGEL LVVEGQTVEV GTPIFTVNGG EADHGVTEPA GEAEQAAVDA
110 120 130 140 150
AASVTHESEE PKAGAVIVGY GSAGHGTSRR RVTHPGAAAR PAAFPPAESA
160 170 180 190 200
AEPGRAPSTP VPPSGGGPVI AKPPIRKLAK DLGVDLSTVT ATGAIGEVTR
210 220 230 240 250
EDVLREGTQA SVFRNIQTPE WPDDREERIL VKGVRKAIAN AMVTSAFSAP
260 270 280 290 300
HVSVFVDVDA TRTMEFVKRL KSAPDFVGVK VSPLLIMAKA IVWAVRRNPT
310 320 330 340 350
VNSTWTDEEI IVRHYVNLGI AAATPRGLIV PNVKEAQGMS LLELAGALEE
360 370 380 390 400
LTLTAREGKT QPADMANGTI TITNIGVFGM DTGTPILNPG EVGIVALGTI
410 420 430 440 450
KQKPWVVDGE VRPRFVTTLG GSFDHRVVDG DVASRFLADV ASIIEEPALL

LD
Length:452
Mass (Da):47,427
Last modified:September 13, 2004 - v1
Checksum:iE82E69643536926A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT90113.1.
RefSeqiWP_011187092.1. NC_006087.1.
YP_063218.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT90113; AAT90113; Lxx25050.
GeneIDi2940497.
KEGGilxx:Lxx25050.
PATRICi22338780. VBILeiXyl11655_2622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT90113.1 .
RefSeqi WP_011187092.1. NC_006087.1.
YP_063218.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6ABX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx25050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT90113 ; AAT90113 ; Lxx25050 .
GeneIDi 2940497.
KEGGi lxx:Lxx25050.
PATRICi 22338780. VBILeiXyl11655_2622.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281564.
KOi K00627.
OMAi TIKQKPW.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci LXYL281090:GH0X-2349-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiODP2_LEIXX
AccessioniPrimary (citable) accession number: Q6ABX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: September 13, 2004
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3