Q6ABX8 (ODPB_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate dehydrogenase E1 component subunit beta
EC=1.2.4.1

Gene names

Name:	pdhB
Ordered Locus Names:	Lxx25060

Organism

Leifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]

Taxonomic identifier

281090 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia › Leifsonia xyli › Leifsonia xyli subsp. xyli

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain By similarity.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Pyruvate Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Pyruvate dehydrogenase E1 component subunit beta		PRO_0000232457
Sites
	Binding site	73	1	Thiamine pyrophosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ABX8 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 2B45A895DC8D84E2	FASTA	337	36,087
	10 20 30 40 50 60 MERAPALAEP EPRVQSLPMV KALNAGLRQA LVADPKVLIL GEDVGPLGGV FRVTEGLQSE 70 80 90 100 110 120 FGASRVVDTP LAEAGIVGTA IGLAMRGYRP VVEIQFNGFV FPGFDQITTQ LAKMANRHSG 130 140 150 160 170 180 AVSMPVVIRI PHGGHIGAVE HHQEAPEAYF AHTAGLRIVA PSTPHDAYWM IQEAIASDDP 190 200 210 220 230 240 VIFFEPMSRY WPKGEVDTLE NPLPLHASRI VRSGTDATIV AWAGMVPVAL RAAEIAAEEG 250 260 270 280 290 300 RSLEVVDLRS LAPIDYAPVL RSVQKTGRLV VAQEAPGIVS VGSEVAAVVG EKAFYSLEAP 310 320 330 VLRVAGFDTP FPPAKLESLY LPDADRILEV VDRSLAY

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT90114.1.
RefSeq	YP_063219.1. NC_006087.1.
3D structure databases
ProteinModelPortal	Q6ABX8.
ModBase	Search...
Protein-protein interaction databases
STRING	281090.Lxx25060.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT90114; AAT90114; Lxx25060.
GeneID	2940400.
KEGG	lxx:Lxx25060.
PATRIC	22338782. VBILeiXyl11655_2623.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0022.
HOGENOM	HOG000281451.
KO	K00162.
OMA	TIVAWAG.
ProtClustDB	CLSK831543.
Enzyme and pathway databases
BioCyc	LXYL281090:GH0X-2350-MONOMER.
Family and domain databases
Gene3D	3.40.50.920. 1 hit.
InterPro	IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. [Graphical view]
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODPB_LEIXX

Accession

Primary (citable) accession number: Q6ABX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program