Q6ABS5 (FTHS_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	PPA0049

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium › Propionibacterium acnes

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.
Sequence caution	The sequence AAT81808.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_0000199369
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ABS5 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 6BE2573EA8575BA1	FASTA	563	59,660
	10 20 30 40 50 60 MKSDLEIARE AHLDPIEKVA ARAGIDEKYL EPYGRGVAKV DLDVVTHNRD HSCGKYVVVT 70 80 90 100 110 120 AMTPTPLGEG KTTTAVGLAQ GLEKIGKHSV LALRQPSMGP TFGIKGGAAG AGYSQVLPME 130 140 150 160 170 180 KLNLHLTGDF HAIGAAHNLL AAMIDNHLHQ GNELDIEPHS ISWRRVVDIN DRALRNTIVG 190 200 210 220 230 240 LGSRVDGVPR ETGFDITAAS EVGVILSLAT SLSDLRARLG RIVIGYNRSK EPVSAEDLHA 250 260 270 280 290 300 AGSMAVILKD ALKPNLLQTT ENSPVLVHAG PFGNIATGNS SVIADRVGIG CGDYLLTEAG 310 320 330 340 350 360 FGADMGAERF FNIKCRIGGM RPDAAVLVAT VRALKTHAGR YKVIPGKPLP PAMLEDNPDD 370 380 390 400 410 420 VLAGAANLRK HIEIVREFGV SPIVALNVFP TDHPDEIDAV RKVAEAAGAH FASSTHVVDG 430 440 450 460 470 480 GDGAVDLAHA VVAACDHKAD FRYTYDLEDS LVEKLTKVAT KVYGADGIDI APAAAKELAH 490 500 510 520 530 540 FEDLGYGTFP VVIAKTHLSL SHDPSLKGAP TGWRLPVREV RAAVGAGYIY AICGDMRTMP 550 560 GLGRHPAAER IDIDDNGETI GLF

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT81808.1. Different initiation.
RefSeq	YP_054766.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6ABS5.
ModBase	Search...
Protein-protein interaction databases
STRING	267747.PPA0049.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT81808; AAT81808; PPA0049.
GeneID	2932562.
KEGG	pac:PPA0049.
PATRIC	23034719. VBIProAcn64440_0047.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
OMA	RMQHEAN.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	PACN267747:GHO9-100-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_PROAC

Accession

Primary (citable) accession number: Q6ABS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program