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Q6ABS5 (FTHS_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PPA0049
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence caution

The sequence AAT81808.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199369

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6ABS5 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 6BE2573EA8575BA1

FASTA56359,660
        10         20         30         40         50         60 
MKSDLEIARE AHLDPIEKVA ARAGIDEKYL EPYGRGVAKV DLDVVTHNRD HSCGKYVVVT 

        70         80         90        100        110        120 
AMTPTPLGEG KTTTAVGLAQ GLEKIGKHSV LALRQPSMGP TFGIKGGAAG AGYSQVLPME 

       130        140        150        160        170        180 
KLNLHLTGDF HAIGAAHNLL AAMIDNHLHQ GNELDIEPHS ISWRRVVDIN DRALRNTIVG 

       190        200        210        220        230        240 
LGSRVDGVPR ETGFDITAAS EVGVILSLAT SLSDLRARLG RIVIGYNRSK EPVSAEDLHA 

       250        260        270        280        290        300 
AGSMAVILKD ALKPNLLQTT ENSPVLVHAG PFGNIATGNS SVIADRVGIG CGDYLLTEAG 

       310        320        330        340        350        360 
FGADMGAERF FNIKCRIGGM RPDAAVLVAT VRALKTHAGR YKVIPGKPLP PAMLEDNPDD 

       370        380        390        400        410        420 
VLAGAANLRK HIEIVREFGV SPIVALNVFP TDHPDEIDAV RKVAEAAGAH FASSTHVVDG 

       430        440        450        460        470        480 
GDGAVDLAHA VVAACDHKAD FRYTYDLEDS LVEKLTKVAT KVYGADGIDI APAAAKELAH 

       490        500        510        520        530        540 
FEDLGYGTFP VVIAKTHLSL SHDPSLKGAP TGWRLPVREV RAAVGAGYIY AICGDMRTMP 

       550        560 
GLGRHPAAER IDIDDNGETI GLF 

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT81808.1. Different initiation.
RefSeqYP_054766.1. NC_006085.1.

3D structure databases

ProteinModelPortalQ6ABS5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267747.PPA0049.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT81808; AAT81808; PPA0049.
GeneID2932562.
KEGGpac:PPA0049.
PATRIC23034719. VBIProAcn64440_0047.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAGIEHEAS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycPACN267747:GHO9-47-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PROAC
AccessionPrimary (citable) accession number: Q6ABS5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways