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Q6ABS5

- FTHS_PROAC

UniProt

Q6ABS5 - FTHS_PROAC

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, PPA0049
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:GHO9-47-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:PPA0049
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA0049.

Structurei

3D structure databases

ProteinModelPortaliQ6ABS5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ABS5-1 [UniParc]FASTAAdd to Basket

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MKSDLEIARE AHLDPIEKVA ARAGIDEKYL EPYGRGVAKV DLDVVTHNRD    50
HSCGKYVVVT AMTPTPLGEG KTTTAVGLAQ GLEKIGKHSV LALRQPSMGP 100
TFGIKGGAAG AGYSQVLPME KLNLHLTGDF HAIGAAHNLL AAMIDNHLHQ 150
GNELDIEPHS ISWRRVVDIN DRALRNTIVG LGSRVDGVPR ETGFDITAAS 200
EVGVILSLAT SLSDLRARLG RIVIGYNRSK EPVSAEDLHA AGSMAVILKD 250
ALKPNLLQTT ENSPVLVHAG PFGNIATGNS SVIADRVGIG CGDYLLTEAG 300
FGADMGAERF FNIKCRIGGM RPDAAVLVAT VRALKTHAGR YKVIPGKPLP 350
PAMLEDNPDD VLAGAANLRK HIEIVREFGV SPIVALNVFP TDHPDEIDAV 400
RKVAEAAGAH FASSTHVVDG GDGAVDLAHA VVAACDHKAD FRYTYDLEDS 450
LVEKLTKVAT KVYGADGIDI APAAAKELAH FEDLGYGTFP VVIAKTHLSL 500
SHDPSLKGAP TGWRLPVREV RAAVGAGYIY AICGDMRTMP GLGRHPAAER 550
IDIDDNGETI GLF 563
Length:563
Mass (Da):59,660
Last modified:December 6, 2005 - v2
Checksum:i6BE2573EA8575BA1
GO

Sequence cautioni

The sequence AAT81808.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT81808.1. Different initiation.
RefSeqiYP_054766.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT81808; AAT81808; PPA0049.
GeneIDi2932562.
KEGGipac:PPA0049.
PATRICi23034719. VBIProAcn64440_0047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT81808.1 . Different initiation.
RefSeqi YP_054766.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6ABS5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 267747.PPA0049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT81808 ; AAT81808 ; PPA0049 .
GeneIDi 2932562.
KEGGi pac:PPA0049.
PATRICi 23034719. VBIProAcn64440_0047.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PACN267747:GHO9-47-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiFTHS_PROAC
AccessioniPrimary (citable) accession number: Q6ABS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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