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Q6ABS5

- FTHS_PROAC

UniProt

Q6ABS5 - FTHS_PROAC

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:GHO9-47-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PPA0049
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Formate--tetrahydrofolate ligasePRO_0000199369Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA0049.

Structurei

3D structure databases

ProteinModelPortaliQ6ABS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ABS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDLEIARE AHLDPIEKVA ARAGIDEKYL EPYGRGVAKV DLDVVTHNRD
60 70 80 90 100
HSCGKYVVVT AMTPTPLGEG KTTTAVGLAQ GLEKIGKHSV LALRQPSMGP
110 120 130 140 150
TFGIKGGAAG AGYSQVLPME KLNLHLTGDF HAIGAAHNLL AAMIDNHLHQ
160 170 180 190 200
GNELDIEPHS ISWRRVVDIN DRALRNTIVG LGSRVDGVPR ETGFDITAAS
210 220 230 240 250
EVGVILSLAT SLSDLRARLG RIVIGYNRSK EPVSAEDLHA AGSMAVILKD
260 270 280 290 300
ALKPNLLQTT ENSPVLVHAG PFGNIATGNS SVIADRVGIG CGDYLLTEAG
310 320 330 340 350
FGADMGAERF FNIKCRIGGM RPDAAVLVAT VRALKTHAGR YKVIPGKPLP
360 370 380 390 400
PAMLEDNPDD VLAGAANLRK HIEIVREFGV SPIVALNVFP TDHPDEIDAV
410 420 430 440 450
RKVAEAAGAH FASSTHVVDG GDGAVDLAHA VVAACDHKAD FRYTYDLEDS
460 470 480 490 500
LVEKLTKVAT KVYGADGIDI APAAAKELAH FEDLGYGTFP VVIAKTHLSL
510 520 530 540 550
SHDPSLKGAP TGWRLPVREV RAAVGAGYIY AICGDMRTMP GLGRHPAAER
560
IDIDDNGETI GLF
Length:563
Mass (Da):59,660
Last modified:December 6, 2005 - v2
Checksum:i6BE2573EA8575BA1
GO

Sequence cautioni

The sequence AAT81808.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT81808.1. Different initiation.
RefSeqiYP_054766.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT81808; AAT81808; PPA0049.
GeneIDi2932562.
KEGGipac:PPA0049.
PATRICi23034719. VBIProAcn64440_0047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT81808.1 . Different initiation.
RefSeqi YP_054766.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6ABS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA0049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT81808 ; AAT81808 ; PPA0049 .
GeneIDi 2932562.
KEGGi pac:PPA0049.
PATRICi 23034719. VBIProAcn64440_0047.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PACN267747:GHO9-47-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiFTHS_PROAC
AccessioniPrimary (citable) accession number: Q6ABS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 1, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3