Q6ABL5 (DNAA_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	PPA0001

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114232
Regions
	Nucleotide binding	203 – 210	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6ABL5 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 4656DA79E051F60C	FASTA	500	56,018
	10 20 30 40 50 60 MSDTPFGDAD HPRPAPIHPD AVLPPPMSSQ SADNDPTEAL NEAWTNILTK VSKPNRAWLS 70 80 90 100 110 120 NTTPVTMHSS TAMVAVPNEF ARDRLESKMR YELEELLSDH FHKAIHLAIT IDPDLELALG 130 140 150 160 170 180 APDHEDEEEE VPPAQFVPKV TVGVTEPSAR PTTTIDDDEG NRLNPKYTFD SFVIGASNRF 190 200 210 220 230 240 AHAAAVAVAE APGKSYNPLL IYGGSGLGKT HLLHAIGRYV MSYYDNVKVK YVSTEELTND 250 260 270 280 290 300 FINAIGTNRT TEFRRSYRDV DVLLVDDIQF LQSKIQTQEE FFHTFNTLHN AQKQIVMTSD 310 320 330 340 350 360 RPPKLLEALE PRLRSRFEWG LLTDIQPPDL ETRIAILRRK VAAEKITVEP DVLEFIASRI 370 380 390 400 410 420 QTNIRELEGA LIRVTAFASL NQQPVDISLA EVVLKDLIPE GRETPVTPER IIAETADYFD 430 440 450 460 470 480 ISADDLLGTS RAQTLVTARQ IAMYLCRELT DLSLPKIGAE FGGKDHTTVM HADRKIRALM 490 500 GEQRQIFNQV SEITNRIKQY

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT81766.1.
RefSeq	YP_054724.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6ABL5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2931966.
GenomeReviews	Gene locus PPA0001 in contig AE017283_GR.
KEGG	pac:PPA0001.
NMPDR	fig|267747.1.peg.1.
PATRIC	23034625. VBIProAcn64440_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	DEVAFLI.
PhylomeDB	Q6ABL5.
ProtClustDB	CLSK2763007.
Enzyme and pathway databases
BioCyc	PACN267747:PPA0001-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_PROAC

Accession

Primary (citable) accession number: Q6ABL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program