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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

PPA0296

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Metal bindingi171Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi215Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi270Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei296SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Enzyme and pathway databases

BioCyciPACN267747:G1G0Y-332-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.408By similarity)
Gene namesi
Ordered Locus Names:PPA0296
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002119151 – 346Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST346

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi267747.PPA0296

Structurei

3D structure databases

ProteinModelPortaliQ6AB12
SMRiQ6AB12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ Bacteria
COG1995 LUCA
HOGENOMiHOG000221593
KOiK22024
OMAiGHLYPGH

Family and domain databases

InterProiView protein in InterPro
IPR005255 PdxA_fam
PANTHERiPTHR30004 PTHR30004, 1 hit
PfamiView protein in Pfam
PF04166 PdxA, 1 hit
TIGRFAMsiTIGR00557 pdxA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AB12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKTPLLGIT EGDPAGIGPE ITVQAIHNMA DDRSFIPIVY GDPAIISRAC
60 70 80 90 100
SVTGLSETVR RVTSEEHIEP ESNVINVVDT GTVPHADSIE WGSVQELAGR
110 120 130 140 150
AAIASIEAAT DAALSGKTDG VVTSPINKEA IWKTGSEFLG HTEMLGSLCG
160 170 180 190 200
TPDTDTMFVV SGLKIFFATR HMSLREAVDS IRRDLIDHEI HKALRALKVF
210 220 230 240 250
GCNSPKLAVA ALNPHAGEGG HFGTEEIEVL RPAVKSACAE GHNVVGPVPA
260 270 280 290 300
DSVFHKGVIR EYDGVLSLYH DQGHIASKTL DFDGTVSVTA GLPILRTSVD
310 320 330 340
HGTAFDIAGQ GAASPMTMQS ALHVASDFAR FVPVIREEYL PSTGRN
Length:346
Mass (Da):36,659
Last modified:September 13, 2004 - v1
Checksum:i431C4C2534887BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82054.1
RefSeqiWP_002531202.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT82054; AAT82054; PPA0296
GeneIDi2932160
KEGGipac:PPA0296
PATRICifig|267747.3.peg.308

Similar proteinsi

Entry informationi

Entry nameiPDXA2_CUTAK
AccessioniPrimary (citable) accession number: Q6AB12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome