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Q6AAU8

- GPMA_PROAC

UniProt

Q6AAU8 - GPMA_PROAC

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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Tele-phosphohistidine intermediateUniRule annotation
Binding sitei16 – 1612-phospho-D-glycerateUniRule annotation
Binding sitei61 – 6112-phospho-D-glycerateUniRule annotation
Binding sitei99 – 9912-phospho-D-glycerateUniRule annotation
Active sitei183 – 1831UniRule annotation
Binding sitei185 – 18512-phospho-D-glycerateUniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

BioCyciPACN267747:GHO9-362-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:PPA0364
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2492492,3-bisphosphoglycerate-dependent phosphoglycerate mutasePRO_0000229136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA0364.

Structurei

3D structure databases

ProteinModelPortaliQ6AAU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 2322-phospho-D-glycerate bindingUniRule annotation
Regioni88 – 9142-phospho-D-glycerate bindingUniRule annotation
Regioni115 – 11622-phospho-D-glycerate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0588.
HOGENOMiHOG000221682.
KOiK01834.
OMAiKDDERFP.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AAU8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAKLILLRH GESEWNSKNL FTGWVDVDLN EKGEGEARHA ADLLKQENLL
60 70 80 90 100
PDIVHTSLLR RAIHTAYLAL DGCDRHWIPV HRSWRLNERH YGALQGLNKA
110 120 130 140 150
ETKEKYGNDQ FMAWRRSYDV RPPDLDRDSE FSQFHDPRYA DIPASERPVA
160 170 180 190 200
ECLKDVVARM VPYFTSDIAA DLKDGKTVLV AAHGNSLRAL VKHLDEISDE
210 220 230 240
DIAGLNIPTG IPLFYELDDN LKPVTRGGRY LDPEAAAAGA KAVANQGNK
Length:249
Mass (Da):27,990
Last modified:September 13, 2004 - v1
Checksum:iE36BB2762B1D283D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82118.1.
RefSeqiYP_055076.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82118; AAT82118; PPA0364.
GeneIDi2931500.
KEGGipac:PPA0364.
PATRICi23035377. VBIProAcn64440_0373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82118.1 .
RefSeqi YP_055076.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6AAU8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA0364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT82118 ; AAT82118 ; PPA0364 .
GeneIDi 2931500.
KEGGi pac:PPA0364.
PATRICi 23035377. VBIProAcn64440_0373.

Phylogenomic databases

eggNOGi COG0588.
HOGENOMi HOG000221682.
KOi K01834.
OMAi KDDERFP.
OrthoDBi EOG6C8N1H.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00186 .
BioCyci PACN267747:GHO9-362-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
HAMAPi MF_01039. PGAM_GpmA.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view ]
PANTHERi PTHR11931. PTHR11931. 1 hit.
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
TIGRFAMsi TIGR01258. pgm_1. 1 hit.
PROSITEi PS00175. PG_MUTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiGPMA_PROAC
AccessioniPrimary (citable) accession number: Q6AAU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2004
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3