Q6AA77 (OTC_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	PPA0584

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112981
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	273 – 276	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AA77 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 376A96E90BAB5BCF	FASTA	334	36,653
	10 20 30 40 50 60 MAFNLKNRHL LSLAHHSTEE IKFLVGLAAD LKEAKYCGTE QPLLKGKNIA LIFEKASTRT 70 80 90 100 110 120 RCAFEVAAHD QGAHVTYLGP SGSHIGHKES MKDTARVLGR MYDGIEYRGF HQSVVEELAE 130 140 150 160 170 180 YAGVPVFNGL TDEFHPTQML ADALTMREHA EKPFHEIKFA YVGDGRNNMG RSLLLLGAKL 190 200 210 220 230 240 GMDVRIGAPE GLQPEAELVE RCREWAEQSG GKVLVTASAE EAVRDVDFIH TDVWVSMGEP 250 260 270 280 290 300 VESWSERVGT LLPFQINDAL VKAAGNPRVK VMHCLPAFHN SETAVGAEVA KTYPELANGI 310 320 330 EVTESVFESP ACIAFDQAEN RMHTIKAVLV SSLA

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT82339.1.
RefSeq	YP_055297.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6AA77.
SMR	Q6AA77. Positions 2-334.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2931731.
GenomeReviews	Gene locus PPA0584 in contig AE017283_GR.
KEGG	pac:PPA0584.
NMPDR	fig|267747.1.peg.574.
PATRIC	23035871. VBIProAcn64440_0612.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	MTPYQIN.
PhylomeDB	Q6AA77.
ProtClustDB	CLSK2763386.
Enzyme and pathway databases
BioCyc	PACN267747:PPA0584-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_PROAC

Accession

Primary (citable) accession number: Q6AA77

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program