ID   Q6A9X5_CUTAK            Unreviewed;       771 AA.
AC   Q6A9X5;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=PPA0685 {ECO:0000313|EMBL:AAT82441.1};
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Cutibacterium.
OX   NCBI_TaxID=267747 {ECO:0000313|EMBL:AAT82441.1, ECO:0000313|Proteomes:UP000000603};
RN   [1] {ECO:0000313|EMBL:AAT82441.1, ECO:0000313|Proteomes:UP000000603}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202 {ECO:0000313|Proteomes:UP000000603};
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Bruggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Durre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal of
RT   human skin.";
RL   Science 305:671-673(2004).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; AE017283; AAT82441.1; -; Genomic_DNA.
DR   RefSeq; WP_002515306.1; NZ_CP025935.1.
DR   AlphaFoldDB; Q6A9X5; -.
DR   SMR; Q6A9X5; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   EnsemblBacteria; AAT82441; AAT82441; PPA0685.
DR   KEGG; pac:PPA0685; -.
DR   PATRIC; fig|267747.3.peg.718; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_368301_0_0_11; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:AAT82441.1};
KW   Hydrolase {ECO:0000313|EMBL:AAT82441.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          481..728
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   771 AA;  83652 MW;  DBD0A907B0DE43B8 CRC64;
     MTITDTYTEE LAIDLTGSAL LPARKGMDVQ RIDGEDGSLL VEFSATSSGC LFELVGKNGR
     LSVDVDEDRL LGRIDLNGES RSLDAEDALG MADGTIHSVG LTADETGTHL FADGYETFSA
     TLRVWCQDLG ATNIVINPSG VLDVRRFKMW NSALSLQAMA AKAPTATPFV EFAGSELSAR
     DARRIGELAH GALRARTRLR GKGQGGTVLA AQGSAGELSF EIVNGDLLLH VEVDDEPIAH
     VRAPGKWDDG NWHDLVAISG RGAIDLYVDG FLVAHEPGEA FFADLGKVER VTVGKDLEGA
     RLFGEAQTAS IFSSALTDAQ VKRLANVAPL RTQALFDTGY LGSKSYRIPS LIRLDSGSFI
     AGADQRVSIA NDSPNDINFV IRRSEDGRRW DEAQIVLEYP GEGALGASVI DSVLFQDHNS
     GRVFCLIDQF PGGVGQPNAE PGSGFDEQGR QLLFDRDATA YVIDAEGIVT TESGEPTDYT
     VDETGNVFAA GAPAGNIHLA TGVDPHESLL TLRTCNLILI HSDDDGRTWS RPINLNPALK
     QPWMRFLGTS PGNGIQLEHG THRGRLLAPV YYNHEEGKTF SCAAVYSDDG GQTWNLGKSP
     NDERELFGKI VSSRNLNDDR GSTHESALVE TPDGVVHSFM RNQHPSGRVA HAASVDGGET
     WGEVTFVEQL TEIFSQPNAI SVRDELGTES VVFANASMML PFRGCGVLRQ SFDGGKTWPH
     NRVLNPRHHV YQCMTQQDEQ TLLVLWEREW QGLFLTEVPL SWLTTSRSTL E
//