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Q6A9R8

- GCSP_PROAC

UniProt

Q6A9R8 - GCSP_PROAC

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPACN267747:GHO9-751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PPA0742
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 994994Glycine dehydrogenase (decarboxylating)PRO_0000227114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei716 – 7161N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi267747.PPA0742.

Structurei

3D structure databases

ProteinModelPortaliQ6A9R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A9R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDHAENRCG LEGPRPFSSR HVGSVEDDLR YIAETIGVTS PEQIIRDAIP
60 70 80 90 100
ASVLDSNEGD SSVRTPSFPP AADETTARAE LVEIASGNRV TRALIGRGYY
110 120 130 140 150
GTLTPPVIRR NILENPSWYT AYTPYQPEIS QGRLEMLTIY QQLITDLTGL
160 170 180 190 200
ALANSSLLDE ATAASEGMLL ARRAARKVKS NRFLVHTHLF DQVRDVVLGH
210 220 230 240 250
AEATGIEVVE TDLRDPQSWR PEVEAGCFGV LAPYPDSTGA LWNPSEVFDA
260 270 280 290 300
VHKVGGITIA ECDLLSLTLL APPGELGADV AVGSSQRFGV PMGNGGPHAA
310 320 330 340 350
YMSVRSGLER QIPGRLVGVS TDADGNPAYR LALQTREQHI RRDKATSNIC
360 370 380 390 400
TAQVLLAVVA AAYAVWHGPT GLTRIARQVT DRAHQLASAL RAAGLDVADQ
410 420 430 440 450
QFFDTIRIRT KGGAKELWNR AREGGYTLDL VDGDILQISV DETVTDDELR
460 470 480 490 500
ELTQLLGGST DEIRGPADRA WPEDLRRTSS FMTHPVFSSY HTETTMMRYL
510 520 530 540 550
KRLADHDYGL DRGMIPLGSC TMKLNAAAEM EAMTWPAFSQ MHPFAPVEDQ
560 570 580 590 600
AGSLRLIRDL EIWLAELTGY DTVSLQPNAG SQGEYTGLAA IRSYHVSRGD
610 620 630 640 650
TERNVCLVPA SAHGTNAASA ASAGLRVVVV KSNDDGTIDR DDLAAKIAAN
660 670 680 690 700
EGRIAAIMIT YPSTHGVYED GVRQVCDMVH EAGGQVYIDG ANFNALVGWG
710 720 730 740 750
QFARIGGDVS HLNLHKTFAI PHGGGGPGVG PVAAKAHLAP FLPGHPLNPR
760 770 780 790 800
NEHPLNDGGT VTHDGHAVSA APFGSVSVLP ISWAYLRLMG LKGLQFATEV
810 820 830 840 850
AVLNANYIAH RLHDKIPILY TGQNGYVAHE CILDLRPLTT ETGITVDDVA
860 870 880 890 900
KRLIDYGFHA PTMSFPVAGT LMVEPTESED LAELDRFCDA MLAIVEEARM
910 920 930 940 950
VQSGHWPAND NPLINAPHPA ARLVADEWNH PYSRELGCYP GMRLGIQRDQ
960 970 980 990
ERGLDVNTVT RIQAKYWPPV GRVDNTYGDR HLVCSCPPPE AFED
Length:994
Mass (Da):107,817
Last modified:September 13, 2004 - v1
Checksum:i793F731ED0AAA673
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82498.1.
RefSeqiYP_055456.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82498; AAT82498; PPA0742.
GeneIDi2931514.
KEGGipac:PPA0742.
PATRICi23036205. VBIProAcn64440_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82498.1 .
RefSeqi YP_055456.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6A9R8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA0742.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT82498 ; AAT82498 ; PPA0742 .
GeneIDi 2931514.
KEGGi pac:PPA0742.
PATRICi 23036205. VBIProAcn64440_0779.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-751-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiGCSP_PROAC
AccessioniPrimary (citable) accession number: Q6A9R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3