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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PPA0742
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002271141 – 994Glycine dehydrogenase (decarboxylating)Add BLAST994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei716N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ6A9R8

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi267747.PPA0742

Structurei

3D structure databases

ProteinModelPortaliQ6A9R8
SMRiQ6A9R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A9R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDHAENRCG LEGPRPFSSR HVGSVEDDLR YIAETIGVTS PEQIIRDAIP
60 70 80 90 100
ASVLDSNEGD SSVRTPSFPP AADETTARAE LVEIASGNRV TRALIGRGYY
110 120 130 140 150
GTLTPPVIRR NILENPSWYT AYTPYQPEIS QGRLEMLTIY QQLITDLTGL
160 170 180 190 200
ALANSSLLDE ATAASEGMLL ARRAARKVKS NRFLVHTHLF DQVRDVVLGH
210 220 230 240 250
AEATGIEVVE TDLRDPQSWR PEVEAGCFGV LAPYPDSTGA LWNPSEVFDA
260 270 280 290 300
VHKVGGITIA ECDLLSLTLL APPGELGADV AVGSSQRFGV PMGNGGPHAA
310 320 330 340 350
YMSVRSGLER QIPGRLVGVS TDADGNPAYR LALQTREQHI RRDKATSNIC
360 370 380 390 400
TAQVLLAVVA AAYAVWHGPT GLTRIARQVT DRAHQLASAL RAAGLDVADQ
410 420 430 440 450
QFFDTIRIRT KGGAKELWNR AREGGYTLDL VDGDILQISV DETVTDDELR
460 470 480 490 500
ELTQLLGGST DEIRGPADRA WPEDLRRTSS FMTHPVFSSY HTETTMMRYL
510 520 530 540 550
KRLADHDYGL DRGMIPLGSC TMKLNAAAEM EAMTWPAFSQ MHPFAPVEDQ
560 570 580 590 600
AGSLRLIRDL EIWLAELTGY DTVSLQPNAG SQGEYTGLAA IRSYHVSRGD
610 620 630 640 650
TERNVCLVPA SAHGTNAASA ASAGLRVVVV KSNDDGTIDR DDLAAKIAAN
660 670 680 690 700
EGRIAAIMIT YPSTHGVYED GVRQVCDMVH EAGGQVYIDG ANFNALVGWG
710 720 730 740 750
QFARIGGDVS HLNLHKTFAI PHGGGGPGVG PVAAKAHLAP FLPGHPLNPR
760 770 780 790 800
NEHPLNDGGT VTHDGHAVSA APFGSVSVLP ISWAYLRLMG LKGLQFATEV
810 820 830 840 850
AVLNANYIAH RLHDKIPILY TGQNGYVAHE CILDLRPLTT ETGITVDDVA
860 870 880 890 900
KRLIDYGFHA PTMSFPVAGT LMVEPTESED LAELDRFCDA MLAIVEEARM
910 920 930 940 950
VQSGHWPAND NPLINAPHPA ARLVADEWNH PYSRELGCYP GMRLGIQRDQ
960 970 980 990
ERGLDVNTVT RIQAKYWPPV GRVDNTYGDR HLVCSCPPPE AFED
Length:994
Mass (Da):107,817
Last modified:September 13, 2004 - v1
Checksum:i793F731ED0AAA673
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82498.1

Genome annotation databases

EnsemblBacteriaiAAT82498; AAT82498; PPA0742
KEGGipac:PPA0742

Similar proteinsi

Entry informationi

Entry nameiGCSP_CUTAK
AccessioniPrimary (citable) accession number: Q6A9R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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