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Q6A9R8 (GCSP_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PPA0742
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length994 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 994994Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227114

Amino acid modifications

Modified residue7161N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6A9R8 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 793F731ED0AAA673

FASTA994107,817
        10         20         30         40         50         60 
MTDHAENRCG LEGPRPFSSR HVGSVEDDLR YIAETIGVTS PEQIIRDAIP ASVLDSNEGD 

        70         80         90        100        110        120 
SSVRTPSFPP AADETTARAE LVEIASGNRV TRALIGRGYY GTLTPPVIRR NILENPSWYT 

       130        140        150        160        170        180 
AYTPYQPEIS QGRLEMLTIY QQLITDLTGL ALANSSLLDE ATAASEGMLL ARRAARKVKS 

       190        200        210        220        230        240 
NRFLVHTHLF DQVRDVVLGH AEATGIEVVE TDLRDPQSWR PEVEAGCFGV LAPYPDSTGA 

       250        260        270        280        290        300 
LWNPSEVFDA VHKVGGITIA ECDLLSLTLL APPGELGADV AVGSSQRFGV PMGNGGPHAA 

       310        320        330        340        350        360 
YMSVRSGLER QIPGRLVGVS TDADGNPAYR LALQTREQHI RRDKATSNIC TAQVLLAVVA 

       370        380        390        400        410        420 
AAYAVWHGPT GLTRIARQVT DRAHQLASAL RAAGLDVADQ QFFDTIRIRT KGGAKELWNR 

       430        440        450        460        470        480 
AREGGYTLDL VDGDILQISV DETVTDDELR ELTQLLGGST DEIRGPADRA WPEDLRRTSS 

       490        500        510        520        530        540 
FMTHPVFSSY HTETTMMRYL KRLADHDYGL DRGMIPLGSC TMKLNAAAEM EAMTWPAFSQ 

       550        560        570        580        590        600 
MHPFAPVEDQ AGSLRLIRDL EIWLAELTGY DTVSLQPNAG SQGEYTGLAA IRSYHVSRGD 

       610        620        630        640        650        660 
TERNVCLVPA SAHGTNAASA ASAGLRVVVV KSNDDGTIDR DDLAAKIAAN EGRIAAIMIT 

       670        680        690        700        710        720 
YPSTHGVYED GVRQVCDMVH EAGGQVYIDG ANFNALVGWG QFARIGGDVS HLNLHKTFAI 

       730        740        750        760        770        780 
PHGGGGPGVG PVAAKAHLAP FLPGHPLNPR NEHPLNDGGT VTHDGHAVSA APFGSVSVLP 

       790        800        810        820        830        840 
ISWAYLRLMG LKGLQFATEV AVLNANYIAH RLHDKIPILY TGQNGYVAHE CILDLRPLTT 

       850        860        870        880        890        900 
ETGITVDDVA KRLIDYGFHA PTMSFPVAGT LMVEPTESED LAELDRFCDA MLAIVEEARM 

       910        920        930        940        950        960 
VQSGHWPAND NPLINAPHPA ARLVADEWNH PYSRELGCYP GMRLGIQRDQ ERGLDVNTVT 

       970        980        990 
RIQAKYWPPV GRVDNTYGDR HLVCSCPPPE AFED 

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT82498.1.
RefSeqYP_055456.1. NC_006085.1.

3D structure databases

ProteinModelPortalQ6A9R8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267747.PPA0742.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT82498; AAT82498; PPA0742.
GeneID2931514.
KEGGpac:PPA0742.
PATRIC23036205. VBIProAcn64440_0779.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAHRYRTET.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPACN267747:GHO9-751-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PROAC
AccessionPrimary (citable) accession number: Q6A9R8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families