SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6A9R8

- GCSP_PROAC

UniProt

Q6A9R8 - GCSP_PROAC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, PPA0742
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPACN267747:GHO9-751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PPA0742
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 994994Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei716 – 7161N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi267747.PPA0742.

Structurei

3D structure databases

ProteinModelPortaliQ6A9R8.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiHRYRTET.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A9R8-1 [UniParc]FASTAAdd to Basket

« Hide

MTDHAENRCG LEGPRPFSSR HVGSVEDDLR YIAETIGVTS PEQIIRDAIP    50
ASVLDSNEGD SSVRTPSFPP AADETTARAE LVEIASGNRV TRALIGRGYY 100
GTLTPPVIRR NILENPSWYT AYTPYQPEIS QGRLEMLTIY QQLITDLTGL 150
ALANSSLLDE ATAASEGMLL ARRAARKVKS NRFLVHTHLF DQVRDVVLGH 200
AEATGIEVVE TDLRDPQSWR PEVEAGCFGV LAPYPDSTGA LWNPSEVFDA 250
VHKVGGITIA ECDLLSLTLL APPGELGADV AVGSSQRFGV PMGNGGPHAA 300
YMSVRSGLER QIPGRLVGVS TDADGNPAYR LALQTREQHI RRDKATSNIC 350
TAQVLLAVVA AAYAVWHGPT GLTRIARQVT DRAHQLASAL RAAGLDVADQ 400
QFFDTIRIRT KGGAKELWNR AREGGYTLDL VDGDILQISV DETVTDDELR 450
ELTQLLGGST DEIRGPADRA WPEDLRRTSS FMTHPVFSSY HTETTMMRYL 500
KRLADHDYGL DRGMIPLGSC TMKLNAAAEM EAMTWPAFSQ MHPFAPVEDQ 550
AGSLRLIRDL EIWLAELTGY DTVSLQPNAG SQGEYTGLAA IRSYHVSRGD 600
TERNVCLVPA SAHGTNAASA ASAGLRVVVV KSNDDGTIDR DDLAAKIAAN 650
EGRIAAIMIT YPSTHGVYED GVRQVCDMVH EAGGQVYIDG ANFNALVGWG 700
QFARIGGDVS HLNLHKTFAI PHGGGGPGVG PVAAKAHLAP FLPGHPLNPR 750
NEHPLNDGGT VTHDGHAVSA APFGSVSVLP ISWAYLRLMG LKGLQFATEV 800
AVLNANYIAH RLHDKIPILY TGQNGYVAHE CILDLRPLTT ETGITVDDVA 850
KRLIDYGFHA PTMSFPVAGT LMVEPTESED LAELDRFCDA MLAIVEEARM 900
VQSGHWPAND NPLINAPHPA ARLVADEWNH PYSRELGCYP GMRLGIQRDQ 950
ERGLDVNTVT RIQAKYWPPV GRVDNTYGDR HLVCSCPPPE AFED 994
Length:994
Mass (Da):107,817
Last modified:September 13, 2004 - v1
Checksum:i793F731ED0AAA673
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82498.1.
RefSeqiWP_011183729.1. NC_006085.1.
YP_055456.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82498; AAT82498; PPA0742.
GeneIDi2931514.
KEGGipac:PPA0742.
PATRICi23036205. VBIProAcn64440_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82498.1 .
RefSeqi WP_011183729.1. NC_006085.1.
YP_055456.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6A9R8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA0742.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT82498 ; AAT82498 ; PPA0742 .
GeneIDi 2931514.
KEGGi pac:PPA0742.
PATRICi 23036205. VBIProAcn64440_0779.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi HRYRTET.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-751-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiGCSP_PROAC
AccessioniPrimary (citable) accession number: Q6A9R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi