Q6A9R6 (GCST_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	PPA0744

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Aminomethyltransferase HAMAP MF_00259		PRO_0000122582

Sequences

	Sequence		Length	Mass (Da)
	Q6A9R6 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 241582D7CA4760C4	FASTA	371	39,520
	10 20 30 40 50 60 MTTLRRTPLA AVHESLGASF TDFAGWNMPV RYSSDLAEHH AVRKNAGIFD LSHMGEIRIS 70 80 90 100 110 120 GPDSGAALDY ALAGKLSAVA EGRAKYSLLL TDEGGVVDDL VTYHLPDGDY LVVANAANAE 130 140 150 160 170 180 TDLAEFTKRC ARFDVTVTDE SAQTALVAVQ GPTAVKIVLA ALQKANTTLD SDEVRDVKYY 190 200 210 220 230 240 RCLTGELDGF PVLVARTGYT GEDGYELYVP AKAAAHLWQL LMDAGGEDLT PCGLACRDTL 250 260 270 280 290 300 RLEAGMPLYG HELGTDIHPS QAGLGRVVNF KKEGDFVGRC ALENRDTTAD RVLVGLTGEG 310 320 330 340 350 360 RRAGRAGYAV VNEDKTVGAI TSGILSPTLG HPIAMAFVDP DVAKIGTSLS VDVRGKALNT 370 TVVELPFYKR S

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT82500.1.
RefSeq	YP_055458.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A9R6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2930895.
GenomeReviews	Gene locus PPA0744 in contig AE017283_GR.
KEGG	pac:PPA0744.
NMPDR	fig|267747.1.peg.735.
PATRIC	23036209. VBIProAcn64440_0781.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q6A9R6.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	PACN267747:PPA0744-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_PROAC

Accession

Primary (citable) accession number: Q6A9R6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program