Q6A9R0 (RSMH_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase H
EC=2.1.1.199

Alternative name(s):
16S rRNA m(4)C1402 methyltransferase
rRNA (cytosine-N(4)-)-methyltransferase RsmH

Gene names

Name:	rsmH
Synonyms:	mraW
Ordered Locus Names:	PPA0750

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA By similarity. HAMAP MF_01007
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. HAMAP MF_01007
Subcellular location	Cytoplasm By similarity HAMAP MF_01007.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmH family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Ribosomal RNA small subunit methyltransferase H HAMAP MF_01007		PRO_0000108681
Regions
	Region	45 – 47	3	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	64	1	S-adenosyl-L-methionine By similarity
	Binding site	91	1	S-adenosyl-L-methionine; via amide nitrogen By similarity
	Binding site	112	1	S-adenosyl-L-methionine By similarity
	Binding site	119	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6A9R0 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: D845B69568DAE2B8	FASTA	337	37,301
	10 20 30 40 50 60 MLMATDAIGS DAVHIPVMRA RILDLLAVVL KSGRRVHVDG TLGMGGHAEA VLRRFPDVEL 70 80 90 100 110 120 VGIDRDQQAL TMAEARLEPF ADRVHLVHAV HDELPEVLDD LGLDYVDSVL LDLGLSSFQI 130 140 150 160 170 180 DEVERGFSYS VDSPLDMRMD QSSGRTAAQI LNESDPGALV RMLREYGEEK FADRIVRAIV 190 200 210 220 230 240 TERDRQPIET SGRLVEIITE AIPATVRRKR HSHPAKRTFQ ALRIAVNREM ETLPAVLPRA 250 260 270 280 290 300 LDRLDVGGRI AVLSYHSLED RPVKEAFRDA CADTAPAGLP MVPESMAAKF NPVTRGAERP 310 320 330 DADEVATNPR SASARLRVIE RVRPGPVNRQ HATKESR

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT82506.1.
RefSeq	YP_055464.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A9R0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2931531.
GenomeReviews	Gene locus PPA0750 in contig AE017283_GR.
KEGG	pac:PPA0750.
NMPDR	fig|267747.1.peg.741.
PATRIC	23036221. VBIProAcn64440_0787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG302779.
OMA	NPATRAF.
PhylomeDB	Q6A9R0.
ProtClustDB	CLSK2763499.
Enzyme and pathway databases
BioCyc	PACN267747:PPA0750-MONOMER.
Family and domain databases
HAMAP	MF_01007. 16SrRNA_methyltr_H. [Tree]
InterPro	IPR002903. SAM-dep_MeTrfase_MraW. IPR023397. SAM-dep_MeTrfase_MraW_recog. [Graphical view]
Gene3D	G3DSA:1.10.150.170. G3DSA:1.10.150.170. 1 hit.
KO	K03438.
PANTHER	PTHR11265. Bact_methyltrans. 1 hit.
Pfam	PF01795. Methyltransf_5. 1 hit. [Graphical view]
PIRSF	PIRSF004486. MraW. 1 hit.
SUPFAM	SSF81799. SSF81799. 1 hit.
TIGRFAMs	TIGR00006. TIGR00006. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RSMH_PROAC

Accession

Primary (citable) accession number: Q6A9R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program