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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:PPA0755
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei53 – 73HelicalUniRule annotationAdd BLAST21
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Transmembranei186 – 206HelicalUniRule annotationAdd BLAST21
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei333 – 353HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088671 – 356Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST356

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA0755

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A9Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNILLAGAV SMIGTLVGTR WFIHWLAAKG YGQFIRDDGP TTHKTKKGTP
60 70 80 90 100
TMGGAVIIVS VLLAYLVAHL VTWTHPSISA LLVLWLFSGL GFIGFLDDWT
110 120 130 140 150
KISKQRSLGL KPKGKLLGQA FVAITFAIGV MYFPDVHGVT PGSPAISFLR
160 170 180 190 200
DISWLYLPVW LGIVWVILLI AGSSNAVNLT DGLDGLATGA STMVFGAYTV
210 220 230 240 250
LSIWQFNQWC SRPTTAGNHC YAVRDPHDIA VVAIAIAGAC FGFLWWNAKP
260 270 280 290 300
AQIFLGDTGS LALGGAVAGM AVVSRTELLL VIIGALFVIE TVSVMLQVSV
310 320 330 340 350
FKITGGKRVF KMAPLHHHFE LKGWAEVTVV IRFWIICGLA VSAGLGIFYA

EWVAGQ
Length:356
Mass (Da):38,314
Last modified:September 13, 2004 - v1
Checksum:i1F263D510C2167FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82511.1
RefSeqiWP_002513927.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT82511; AAT82511; PPA0755
GeneIDi2931150
KEGGipac:PPA0755

Similar proteinsi

Entry informationi

Entry nameiMRAY_CUTAK
AccessioniPrimary (citable) accession number: Q6A9Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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