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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137GTPUniRule annotation1
Binding sitei141GTPUniRule annotation1
Binding sitei185GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 23GTPUniRule annotation5
Nucleotide bindingi106 – 108GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:PPA0761Imported
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)Imported
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA0761.

Structurei

3D structure databases

ProteinModelPortaliQ6A9P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 203TubulinInterPro annotationAdd BLAST193
Domaini205 – 322Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiMRAVKGI.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A9P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPSQNYLA VIKVVGVGGG GCNAVNRMIE AGLKGVEFLA VNTDAQALLT
60 70 80 90 100
SDADVKLDIG RDLTRGLGAG ADPDKGRQAA EDHADEIEES LKGADMVFVT
110 120 130 140 150
AGEGGGTGTG AAPVVAKIAR SLGALTIGVV TRPFSFEGHR RSSQAEQGID
160 170 180 190 200
NLRDEVDTLI VIPNDKLLDM TDQQIAILDA FKQADQVLMQ GVSGITDLIT
210 220 230 240 250
TPGQINLDFA DVKSVMSNAG SALMGIGRAS GEDRARAAAE MAISSPLLEV
260 270 280 290 300
SIDGARGVLL SIAGGSDLGL FEVASAANLI EAAAHDEANI IFGTIIDDAL
310 320 330 340 350
GDEVRVTVIA AGFENGQLTS TKQPGISQRP ASRPAMTNRS SAGVIGAGTG
360 370 380 390 400
SAASTSAGSS SSASRQPADN QRPTPIRPQT QGSPFGKAQS QQQSHPVEPV
410
NPPEEPDDDL DVPDFLK
Length:417
Mass (Da):42,801
Last modified:September 13, 2004 - v1
Checksum:i3AC170B477CCB356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT82517.1.
RefSeqiWP_002530970.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82517; AAT82517; PPA0761.
GeneIDi2931375.
KEGGipac:PPA0761.
PATRICifig|267747.3.peg.798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT82517.1.
RefSeqiWP_002530970.1. NC_006085.1.

3D structure databases

ProteinModelPortaliQ6A9P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267747.PPA0761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT82517; AAT82517; PPA0761.
GeneIDi2931375.
KEGGipac:PPA0761.
PATRICifig|267747.3.peg.798.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiMRAVKGI.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6A9P9_PROAC
AccessioniPrimary (citable) accession number: Q6A9P9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.