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Q6A9J3 (PGK_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:PPA0817
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000076597

Regions

Nucleotide binding356 – 3594ATP By similarity
Region20 – 223Substrate binding By similarity
Region58 – 614Substrate binding By similarity

Sites

Binding site351Substrate By similarity
Binding site1171Substrate By similarity
Binding site1541Substrate By similarity
Binding site2041ATP By similarity
Binding site3301ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6A9J3 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: B5AB7E4EEC9734C1

FASTA40242,218
        10         20         30         40         50         60 
MKSVEDLGDL RGKRVVIRCD FNVPLDGDKI TDDGRIKAAL PTLTQLHEAG ARTTVLAHLG 

        70         80         90        100        110        120 
RPKGAVDPKY SLAPVAKRLG ELMNLDVKLA GDVVGPSATK TSESLADGEI ALVENVRFEK 

       130        140        150        160        170        180 
GETSKDEAER AELAQKYASF GEFYVSNGFG VVHRKQASVY DVAKLLPSAA GSLVAKEVEV 

       190        200        210        220        230        240 
LEGLTADPKR PFVVVLGGAK VADKLAVIDN LLKAADTLVI GGGMAYTFLK AKGLEVGDSL 

       250        260        270        280        290        300 
LDEDSIDACT KYLEQAKAAG KQILLPVDVR VVSDIDFEAR TVGQIDVVPA DEIPSDKMAV 

       310        320        330        340        350        360 
DIGPETEKAY ANAIKGAKSV FWNGPMGVFE IKGLELGTKA VAQALTEVDG LSVVGGGDSA 

       370        380        390        400 
SAVRTLGFAD DQFGHISTGG GASLELMEGK ELPGIAVLKE NN 

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT82573.1.
RefSeqYP_055531.1. NC_006085.1.

3D structure databases

ProteinModelPortalQ6A9J3.
SMRQ6A9J3. Positions 3-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267747.PPA0817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT82573; AAT82573; PPA0817.
GeneID2933008.
KEGGpac:PPA0817.
PATRIC23036355. VBIProAcn64440_0853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAHASVYDI.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycPACN267747:GHO9-827-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_PROAC
AccessionPrimary (citable) accession number: Q6A9J3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways