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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (PPA0769)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35SubstrateUniRule annotation1
Binding sitei117SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Binding sitei204ATPUniRule annotation1
Binding sitei330ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 359ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:G1G0Y-898-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:PPA0817
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000765971 – 402Phosphoglycerate kinaseAdd BLAST402

Proteomic databases

PRIDEiQ6A9J3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi267747.PPA0817

Structurei

3D structure databases

ProteinModelPortaliQ6A9J3
SMRiQ6A9J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 22Substrate bindingUniRule annotation3
Regioni58 – 61Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A9J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVEDLGDL RGKRVVIRCD FNVPLDGDKI TDDGRIKAAL PTLTQLHEAG
60 70 80 90 100
ARTTVLAHLG RPKGAVDPKY SLAPVAKRLG ELMNLDVKLA GDVVGPSATK
110 120 130 140 150
TSESLADGEI ALVENVRFEK GETSKDEAER AELAQKYASF GEFYVSNGFG
160 170 180 190 200
VVHRKQASVY DVAKLLPSAA GSLVAKEVEV LEGLTADPKR PFVVVLGGAK
210 220 230 240 250
VADKLAVIDN LLKAADTLVI GGGMAYTFLK AKGLEVGDSL LDEDSIDACT
260 270 280 290 300
KYLEQAKAAG KQILLPVDVR VVSDIDFEAR TVGQIDVVPA DEIPSDKMAV
310 320 330 340 350
DIGPETEKAY ANAIKGAKSV FWNGPMGVFE IKGLELGTKA VAQALTEVDG
360 370 380 390 400
LSVVGGGDSA SAVRTLGFAD DQFGHISTGG GASLELMEGK ELPGIAVLKE

NN
Length:402
Mass (Da):42,218
Last modified:September 13, 2004 - v1
Checksum:iB5AB7E4EEC9734C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82573.1
RefSeqiWP_002518307.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT82573; AAT82573; PPA0817
GeneIDi2933008
KEGGipac:PPA0817
PATRICifig|267747.3.peg.853

Similar proteinsi

Entry informationi

Entry nameiPGK_CUTAK
AccessioniPrimary (citable) accession number: Q6A9J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health