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Q6A9C5 (THIM_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:PPA0885
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence caution

The sequence AAT82641.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383887

Sites

Binding site551Substrate; via amide nitrogen By similarity
Binding site1301ATP By similarity
Binding site1761ATP By similarity
Binding site2031Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6A9C5 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 12CECB33C6E876AD

FASTA27728,469
        10         20         30         40         50         60 
MPAKGVVDMT ELSNLVAESL ERLRRDKPLV QCLTNIVVAN FTANVLLSAG AVPAMVDNPE 

        70         80         90        100        110        120 
ESEGFASIAD GVLVNTGTPY RETTEAMIAA ARGAASSNTP WVLDPVGVGM SWRTRVVLDT 

       130        140        150        160        170        180 
LDVAAPAVIR ANASEVLALA GTGASSRGPE AGDAVEDALA SATQLVRHYG CVVAISGPVD 

       190        200        210        220        230        240 
HILDADRHVT VSSGHEWMTR VTGVGCSLGA LTAAFAGIQN DHLIAAVSAT AMLCVVAERA 

       250        260        270 
AERSAGPGAF AQALVDELFL VSPDEVGERG GLRDVTA 

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT82641.1. Different initiation.
RefSeqYP_055599.1. NC_006085.1.

3D structure databases

ProteinModelPortalQ6A9C5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267747.PPA0885.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT82641; AAT82641; PPA0885.
GeneID2931842.
KEGGpac:PPA0885.
PATRIC23036487. VBIProAcn64440_0918.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK2763576.

Enzyme and pathway databases

BioCycPACN267747:GHO9-896-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_PROAC
AccessionPrimary (citable) accession number: Q6A9C5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways