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Q6A9B0

- MEND_PROAC

UniProt

Q6A9B0 - MEND_PROAC

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

    Cofactori

    Magnesium or manganese.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciPACN267747:GHO9-912-MONOMER.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:PPA0903
    OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
    Taxonomic identifieri267747 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
    ProteomesiUP000000603: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5085082-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_0000341809Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi267747.PPA0903.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6A9B0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    HOGENOMiHOG000218359.
    KOiK02551.
    OMAiWRSAVCR.
    OrthoDBiEOG6NWBQW.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view]
    PfamiPF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6A9B0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSTAVARR LVNALVEAGV EHVVYCPGSR DAPIGYALAD AETAGWLRVY    50
    VRLDERSAGF VALGLGRAGC PAALVTTSGT AVANIHPAVL EADAAGVPLI 100
    VLSADRPAEM WHTGANQTTV QTGIFGSAPR LSTDVPAGFP ADERLDALVL 150
    RAVTAATGAL SADPGPVHLN VSFRDSLVPD GPWQPQALVP RRVSSFPTAP 200
    TPLVMPARTV VVAGDGAGSL ARELAQQGGW PLLAEPTSGS RVGDNALTDY 250
    QTVLGSELVD DVEAVLVLGH PTLSRPVSRL LARPDVTVVT DRSRWTDVAG 300
    VARVVTGPVE LAEIDTDPAW LGRWKDADRP VVPTAKQRLC RDIWWACTTP 350
    NAPVLVIGAS EVIRCFDRFA VPGDIAPTAL ANRGLAGIDG TIATAIGVGL 400
    GTGRPVRVVV GDLTFAHDAM SLLLGETEPE PDVQVVVLDD RGGAIFSGLE 450
    HAAAPAPVLR RMFLTPQRLD SAALAHALGA SHRRVSPDDL QFLDEPVVGR 500
    QVVSVPLT 508
    Length:508
    Mass (Da):53,075
    Last modified:July 1, 2008 - v2
    Checksum:iB9ADC09A593370E0
    GO

    Sequence cautioni

    The sequence AAT82656.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017283 Genomic DNA. Translation: AAT82656.1. Different initiation.
    RefSeqiYP_055614.1. NC_006085.1.

    Genome annotation databases

    EnsemblBacteriaiAAT82656; AAT82656; PPA0903.
    GeneIDi2930918.
    KEGGipac:PPA0903.
    PATRICi23036523. VBIProAcn64440_0936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017283 Genomic DNA. Translation: AAT82656.1 . Different initiation.
    RefSeqi YP_055614.1. NC_006085.1.

    3D structure databases

    ProteinModelPortali Q6A9B0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267747.PPA0903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT82656 ; AAT82656 ; PPA0903 .
    GeneIDi 2930918.
    KEGGi pac:PPA0903.
    PATRICi 23036523. VBIProAcn64440_0936.

    Phylogenomic databases

    eggNOGi COG1165.
    HOGENOMi HOG000218359.
    KOi K02551.
    OMAi WRSAVCR.
    OrthoDBi EOG6NWBQW.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci PACN267747:GHO9-912-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view ]
    Pfami PF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
      Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
      Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KPA171202 / DSM 16379.

    Entry informationi

    Entry nameiMEND_PROAC
    AccessioniPrimary (citable) accession number: Q6A9B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3