Q6A917 (PYRB_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	PPA0997

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113172

Sequences

	Sequence		Length	Mass (Da)
	Q6A917 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 3C2CD7B829647267	FASTA	314	34,738
	10 20 30 40 50 60 MSTEVVEEFD ADYTGRHFLS VEDMSSDDVM RIIERGRQFK AGDAPRVEPG HVAINMFFEN 70 80 90 100 110 120 STRTMTSFQM AEHRLGMKIL DFDPGHSSVT KGESLYDSVR TVDAIGAEVA VIRHSTNHYY 130 140 150 160 170 180 DYLLATGMLG LSVVNGGDGS GQHPSQCMLD LMTIAEEFGH VDGLTVAISG DIVHSRVARS 190 200 210 220 230 240 DAQILTRLGA NVVFTGPREW MDHDVTRLGT MATLDEVIAD VDVAMMLRVQ HERFDAGPDF 250 260 270 280 290 300 SATDYLHTFG LTDERAERMK PHAIIMHPAP VNRGCEISGH LVEAPSSRIF EQMGNGVMVR 310 MAILEQVLHG RETK

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT82749.1.
RefSeq	YP_055707.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A917.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2930938.
GenomeReviews	Gene locus PPA0997 in contig AE017283_GR.
KEGG	pac:PPA0997.
NMPDR	fig|267747.1.peg.984.
PATRIC	23036719. VBIProAcn64440_1032.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	LQRERMS.
PhylomeDB	Q6A917.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	PACN267747:PPA0997-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_PROAC

Accession

Primary (citable) accession number: Q6A917

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program