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Q6A910 (PYRE_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:PPA1004
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110722

Regions

Region127 – 13595-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site10115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1311Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6A910 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 99EB26E394D1305B

FASTA21623,061
        10         20         30         40         50         60 
MTVTNNEIAR EFAERLLAIE AVSLSPDAPF TWASGLHSPI YCDNRVTLSD PQTRDLIADG 

        70         80         90        100        110        120 
LASLVRTNFH QVDVVAGTAT AGIAHAALAA DRLGAPMAYV RSVPKDHGRG NQIEGRIPAH 

       130        140        150        160        170        180 
SKVIMVEDLI STGGSVLKAA QAVEREGSTV VGVLALFSYE LEKGHRAFEK AGVPLYTLSN 

       190        200        210 
YPILIEVAAE SGRITSEQQA TLATWSSDPQ AWSDAH

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed: 15286373] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017283 Genomic DNA. Translation: AAT82756.1.
RefSeqYP_055714.1. NC_006085.1.

3D structure databases

ProteinModelPortalQ6A910.
SMRQ6A910. Positions 7-213.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2932306.
GenomeReviewsGene locus PPA1004 in contig AE017283_GR.
KEGGpac:PPA1004.
NMPDRfig|267747.1.peg.991.
PATRIC23036733. VBIProAcn64440_1039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMALPMTYVR.
PhylomeDBQ6A910.
ProtClustDBCLSK2763663.

Enzyme and pathway databases

BioCycPACN267747:PPA1004-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_PROAC
AccessionPrimary (citable) accession number: Q6A910
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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