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Q6A8L5

- HISX_PROAC

UniProt

Q6A8L5 - HISX_PROAC

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Protein
Histidinol dehydrogenase
Gene
hisD, PPA1152
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NAD By similarity
Binding sitei193 – 1931NAD By similarity
Binding sitei222 – 2221NAD By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Metal bindingi270 – 2701Zinc By similarity
Binding sitei270 – 2701Substrate By similarity
Active sitei336 – 3361Proton acceptor By similarity
Active sitei337 – 3371Proton acceptor By similarity
Binding sitei337 – 3371Substrate By similarity
Metal bindingi370 – 3701Zinc By similarity
Binding sitei370 – 3701Substrate By similarity
Binding sitei424 – 4241Substrate By similarity
Metal bindingi429 – 4291Zinc By similarity
Binding sitei429 – 4291Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPACN267747:GHO9-1165-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PPA1152
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Histidinol dehydrogenaseUniRule annotation
PRO_0000135817Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1152.

Structurei

3D structure databases

ProteinModelPortaliQ6A8L5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiQKSLHAV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A8L5-1 [UniParc]FASTAAdd to Basket

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MLRIVDVTSE TTDDLRCAVP RADFDVDAAM AAVIPVCSAV RDRGVEALRE    50
YSEKFDHVVP EHLRVPVEAL ATAAANLDGT LRRAFSESIR RRRQVCQEAE 100
VETSSQPVEV AGGARVSQRI VPVGRVGLYV PGGFAPLASS VIMNVVPAQE 150
AGVSSIAVAS PPQAEFGGLP HPSILALCHL LGVNEVYAVG GAQAIAMFAY 200
GVEGSDEADS CPRVDMVTGP GNIYVVAAKR CLRGTVGIDS EAGPTEIAIL 250
ADETADPRHI AADLMSQAEH DTLAAAVLVT DSTTLAEAVQ RELAPMVSAT 300
LHSERIRTSL TSKQSAIVMV RDIDQGLEVV NAYAAEHLEI QTADAAAVAA 350
RVWNAGAIFV GPWAPVSLGD YSAGSTHVLP TAGAACHSSG LSVRSFMRAV 400
HVIDYTEDAL LELADSVEAF ALAENLPGHA NAITVRRSR 439
Length:439
Mass (Da):46,098
Last modified:September 13, 2004 - v1
Checksum:iF1B7C0C567681677
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82901.1.
RefSeqiYP_055859.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82901; AAT82901; PPA1152.
GeneIDi2932004.
KEGGipac:PPA1152.
PATRICi23037039. VBIProAcn64440_1188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82901.1 .
RefSeqi YP_055859.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6A8L5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 267747.PPA1152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT82901 ; AAT82901 ; PPA1152 .
GeneIDi 2932004.
KEGGi pac:PPA1152.
PATRICi 23037039. VBIProAcn64440_1188.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi QKSLHAV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PACN267747:GHO9-1165-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiHISX_PROAC
AccessioniPrimary (citable) accession number: Q6A8L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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