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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19MagnesiumUniRule annotation1
Metal bindingi80MagnesiumUniRule annotation1
Metal bindingi153MagnesiumUniRule annotation1
Metal bindingi156MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:PPA1158
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002251621 – 196Crossover junction endodeoxyribonuclease RuvCAdd BLAST196

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1158

Structurei

3D structure databases

ProteinModelPortaliQ6A8K9
SMRiQ6A8K9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105NHU Bacteria
COG0817 LUCA
HOGENOMiHOG000012182
KOiK01159
OMAiGLTRCGI

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A8K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPKSTPDR RVTRVMGVDP GLTRCGVGVV EGGLGSSLKL IAVGVIRTPA
60 70 80 90 100
DLDHAHRLLR IHDGLEEWRD HTRPDAIAVE KVFAQHNRNT VAGTAQAAGI
110 120 130 140 150
AMMIAARHGL PVALHTPSEV KAAISGSGRA DKAQVGFMVA RVLRLSAPPK
160 170 180 190
PADAADAVAL AICHLWRGGA ARRIEAAVAT QRRGRRVPRS WKDLAR
Length:196
Mass (Da):20,877
Last modified:September 13, 2004 - v1
Checksum:i1B12CA32DD983E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82907.1

Genome annotation databases

EnsemblBacteriaiAAT82907; AAT82907; PPA1158
KEGGipac:PPA1158

Similar proteinsi

Entry informationi

Entry nameiRUVC_CUTAK
AccessioniPrimary (citable) accession number: Q6A8K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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