Reviewed, UniProtKB/Swiss-Prot Q6A8F1 (DEOC1_PROAC)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase 1
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase 1
      Short name=Deoxyriboaldolase 1
      Short name=DERA 1

Gene names

Name:	deoC1
Ordered Locus Names:	PPA1214

Organism

Propionibacterium acnes [Complete proteome] [HAMAP]

Taxonomic identifier

1747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Deoxyribose-phosphate aldolase 1 HAMAP MF_00114		PRO_0000231559
Sites
	Active site	151	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	180	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6A8F1-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 616ADB615CEFDC62	FASTA	217	22,617
	10 20 30 40 50 60 MSIAALIDHT LLAPDVTAQH IRTLCREAVD HGFATVCVSP TRVRLAADEL AGHAPRVCSV 70 80 90 100 110 120 IGFPSGAHLS EIRAAETKAA VNDGADEIDM VINVGAVKDD DWDTVESDIS AVVDAAGMAI 130 140 150 160 170 180 VKVILEVSEL TDEEITRACQ AAERCGADFV KTSTGYSRHG ATAEAVSLMR RTVGDRLGVK 190 200 210 ASGGIRTHND VATMLRAGAT RIGASAGVAL LVDEEAL

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT82964.1.
RefSeq	YP_055922.1.
3D structure databases
SMR	Q6A8F1. Positions 3-214.
ModBase	Search...
Genome annotation databases
GeneID	2931397.
GenomeReviews	Gene locus PPA1214 in contig AE017283_GR.
KEGG	pac:PPA1214.
NMPDR	fig|267747.1.peg.1199.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	AKMIDHT.
Enzyme and pathway databases
BioCyc	PACN267747:PPA1214-MONOMER.
BRENDA	4.1.2.4. 39123.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC1_PROAC

Accession

Primary (citable) accession number: Q6A8F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2004
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)