Q6A7W9 (PPNK_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	PPA1395

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229676

Sequences

	Sequence		Length	Mass (Da)
	Q6A7W9 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: FD155F9C1DA16E6A	FASTA	318	34,945
	10 20 30 40 50 60 MGRYCGLVND TSPSRYVVVV THATRDDAFD AAAEFISEMA GRDIGCAVPD DQAKPMSSKL 70 80 90 100 110 120 PGIDLESLGE FAHEAEVVVV FGGDGTILRA AEWSLPRHVP MIGVNLGHVG FLAELERSDM 130 140 150 160 170 180 ADLVNKVCSR DYTVEDRLVL KTTVTEHSGQ HRWSSFAVNE LSLEKAARRR MLDVLASVDE 190 200 210 220 230 240 LPVQRWSCDG ILVSTPTGST AYAFSAGGPV MWPDLDAMLM VPLSAHALFA RPLVMSPAAR 250 260 270 280 290 300 VDLDIQPDGS ESAVLWCDGR RSCTVRPGER ITVVRHPDRL RIARLAAQPF TSRLVKKFEL 310 PVSGWRQGRD RHHLEETS

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT83146.1.
RefSeq	YP_056104.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A7W9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2931825.
GenomeReviews	Gene locus PPA1395 in contig AE017283_GR.
KEGG	pac:PPA1395.
NMPDR	fig|267747.1.peg.1381.
PATRIC	23037555. VBIProAcn64440_1440.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	GPVVWPE.
PhylomeDB	Q6A7W9.
ProtClustDB	PRK03372.
Enzyme and pathway databases
BioCyc	PACN267747:PPA1395-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_PROAC

Accession

Primary (citable) accession number: Q6A7W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program