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Protein

NAD kinase

Gene

nadK

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84Proton acceptorUniRule annotation1
Binding sitei89NADUniRule annotation1
Binding sitei170NADUniRule annotation1
Binding sitei189NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 85NADUniRule annotation2
Nucleotide bindingi159 – 160NADUniRule annotation2
Nucleotide bindingi200 – 205NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:G1G0Y-1525-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PPA1395
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296761 – 318NAD kinaseAdd BLAST318

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1395

Structurei

3D structure databases

ProteinModelPortaliQ6A7W9
SMRiQ6A7W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227223
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A7W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRYCGLVND TSPSRYVVVV THATRDDAFD AAAEFISEMA GRDIGCAVPD
60 70 80 90 100
DQAKPMSSKL PGIDLESLGE FAHEAEVVVV FGGDGTILRA AEWSLPRHVP
110 120 130 140 150
MIGVNLGHVG FLAELERSDM ADLVNKVCSR DYTVEDRLVL KTTVTEHSGQ
160 170 180 190 200
HRWSSFAVNE LSLEKAARRR MLDVLASVDE LPVQRWSCDG ILVSTPTGST
210 220 230 240 250
AYAFSAGGPV MWPDLDAMLM VPLSAHALFA RPLVMSPAAR VDLDIQPDGS
260 270 280 290 300
ESAVLWCDGR RSCTVRPGER ITVVRHPDRL RIARLAAQPF TSRLVKKFEL
310
PVSGWRQGRD RHHLEETS
Length:318
Mass (Da):34,945
Last modified:September 13, 2004 - v1
Checksum:iFD155F9C1DA16E6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT83146.1
RefSeqiWP_002526374.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT83146; AAT83146; PPA1395
GeneIDi2931825
KEGGipac:PPA1395
PATRICifig|267747.3.peg.1440

Similar proteinsi

Entry informationi

Entry nameiNADK_CUTAK
AccessioniPrimary (citable) accession number: Q6A7W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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