Q6A7P7 (DAPB_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	PPA1470

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228372

Sequences

	Sequence		Length	Mass (Da)
	Q6A7P7 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 065B38074FA84D8C	FASTA	246	25,944
	10 20 30 40 50 60 MIKVAVFGAK GRMGTAVCQA VEEAEDTELV AAVDSGGDRS DASGADVIVD FTTPDAVMDN 70 80 90 100 110 120 LSWAISHDIN TVVGTTGFDD ERYQVLRDQL ADHPNIGCLV APNFSIGAVL MMHFAEQAAR 130 140 150 160 170 180 FYESAEIVEL HHPNKVDAPS GTARTTATKI AAARQEAGLG EVPDATKSQL NGARGAVVEG 190 200 210 220 230 240 VHVHSVRLRG LVAHQEVLFG AEGETLTIRH DSMDRVSFMS GVLTGVRGVL DRPGLTVGIE GLLGLE

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT83218.1.
RefSeq	YP_056176.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A7P7.
SMR	Q6A7P7. Positions 2-246.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2931618.
GenomeReviews	Gene locus PPA1470 in contig AE017283_GR.
KEGG	pac:PPA1470.
NMPDR	fig|267747.1.peg.1453.
PATRIC	23037719. VBIProAcn64440_1518.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG594002.
OMA	DRASFMP.
PhylomeDB	Q6A7P7.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	PACN267747:PPA1470-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_PROAC

Accession

Primary (citable) accession number: Q6A7P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program