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Q6A7M5 (IF2_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:PPA1493
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length964 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 964964Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000228227

Regions

Nucleotide binding467 – 4748GTP By similarity
Nucleotide binding517 – 5215GTP By similarity
Nucleotide binding571 – 5744GTP By similarity
Region461 – 613153G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q6A7M5 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 9552FDDDAB499C4B

FASTA964101,394
        10         20         30         40         50         60 
MAKVRVYELA KELGLSSKQL LGKLNDMGEF VRSASSTIEA PVVRRLRDQI GSAEPADDAK 

        70         80         90        100        110        120 
AAKPAARKSQ TSSKKTSKET TTAKPAPGPK PGPGPKPTPG PRPGSSSGPK PGRSSAARTS 

       130        140        150        160        170        180 
ATPRPGLIKS SGASSQQEPP AAKPESKPTP KPGQNVPKPH APAPKPKPGA PSKSPKPGAR 

       190        200        210        220        230        240 
PGPRPGGSAG LPSAARPGPR PGAGRRTGAP RPGNNPFASS QGMGQSRHRS EGGQRSGGSR 

       250        260        270        280        290        300 
SGQGERMPRP GGSQGSRGGS GMPRPNPAMM PKHQSSQIGQ ATTGRGGRGG GRGRGGSRGS 

       310        320        330        340        350        360 
GFGGGFGGGP RGPIGGGRGG RGGRGTQGAF GRGGGGRRGR KSRKQRRQEF DEMQAPLVGG 

       370        380        390        400        410        420 
VRVRKGNGET VRLRRGASLT DLAEKINAEP AQLVQVLFNL GEMVTATQSV SDDTLEILGG 

       430        440        450        460        470        480 
ELNYQIQVVS PEDEDRELLE SFDLEFGEDE GDDSDLVARP PVVTVMGHVD HGKTKLLDAL 

       490        500        510        520        530        540 
RHTDVVKGEA GGITQAIGAY QVQTEVDDAE RAITFIDTPG HEAFTAMRAR GAQSTDIAVL 

       550        560        570        580        590        600 
VVAADDGVMP QTVEALNHAK AADVPIVVAV NKIDKPEADP DKVRGQLTEY GLVPEEYGGD 

       610        620        630        640        650        660 
TMFVNVSART HEGLDDLLEA IVLTADAALD LRANPDMAAQ GVAIEAHLDK GRGPVATALI 

       670        680        690        700        710        720 
QRGTLHIGDS IVAGSSYGRV RAMINDQGES VDEAAPATPV QVLGLTSVPG AGDNFLVVDD 

       730        740        750        760        770        780 
DRKARQIAEK REARMRAAQQ ARSSRRKTLD QLFEQLEKGE TEELLLILKG DGAGSVEALE 

       790        800        810        820        830        840 
DALAKIDVGD EVDLRVIDRG VGAITETNVS LAAASNAVIV GFNVRPTAHA QRMADEENVD 

       850        860        870        880        890        900 
IRYYSVIYDA IDEIEAALRG MLKPIYEEKA MGTAEIRQIF RSSKVGTIAG CMITDGTIRR 

       910        920        930        940        950        960 
HAKARLVRDG VVVQETEINT LQREKDAVTE VREGYECGLT LTNYSDIHVG DEVQCYEMVE 


KPRD 

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References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT83240.1.
RefSeqYP_056198.1. NC_006085.1.

3D structure databases

ProteinModelPortalQ6A7M5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267747.PPA1493.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT83240; AAT83240; PPA1493.
GeneID2931981.
KEGGpac:PPA1493.
PATRIC23037759. VBIProAcn64440_1538.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMANPDMDAQ.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycPACN267747:GHO9-1515-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIF2_PROAC
AccessionPrimary (citable) accession number: Q6A7M5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries