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Q6A7M5

- IF2_PROAC

UniProt

Q6A7M5 - IF2_PROAC

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi467 – 4748GTPUniRule annotation
Nucleotide bindingi517 – 5215GTPUniRule annotation
Nucleotide bindingi571 – 5744GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:GHO9-1515-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:PPA1493
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Translation initiation factor IF-2PRO_0000228227Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1493.

Structurei

3D structure databases

ProteinModelPortaliQ6A7M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini458 – 629172tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni467 – 4748G1By similarity
Regioni492 – 4965G2By similarity
Regioni517 – 5204G3By similarity
Regioni571 – 5744G4By similarity
Regioni607 – 6093G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A7M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKVRVYELA KELGLSSKQL LGKLNDMGEF VRSASSTIEA PVVRRLRDQI
60 70 80 90 100
GSAEPADDAK AAKPAARKSQ TSSKKTSKET TTAKPAPGPK PGPGPKPTPG
110 120 130 140 150
PRPGSSSGPK PGRSSAARTS ATPRPGLIKS SGASSQQEPP AAKPESKPTP
160 170 180 190 200
KPGQNVPKPH APAPKPKPGA PSKSPKPGAR PGPRPGGSAG LPSAARPGPR
210 220 230 240 250
PGAGRRTGAP RPGNNPFASS QGMGQSRHRS EGGQRSGGSR SGQGERMPRP
260 270 280 290 300
GGSQGSRGGS GMPRPNPAMM PKHQSSQIGQ ATTGRGGRGG GRGRGGSRGS
310 320 330 340 350
GFGGGFGGGP RGPIGGGRGG RGGRGTQGAF GRGGGGRRGR KSRKQRRQEF
360 370 380 390 400
DEMQAPLVGG VRVRKGNGET VRLRRGASLT DLAEKINAEP AQLVQVLFNL
410 420 430 440 450
GEMVTATQSV SDDTLEILGG ELNYQIQVVS PEDEDRELLE SFDLEFGEDE
460 470 480 490 500
GDDSDLVARP PVVTVMGHVD HGKTKLLDAL RHTDVVKGEA GGITQAIGAY
510 520 530 540 550
QVQTEVDDAE RAITFIDTPG HEAFTAMRAR GAQSTDIAVL VVAADDGVMP
560 570 580 590 600
QTVEALNHAK AADVPIVVAV NKIDKPEADP DKVRGQLTEY GLVPEEYGGD
610 620 630 640 650
TMFVNVSART HEGLDDLLEA IVLTADAALD LRANPDMAAQ GVAIEAHLDK
660 670 680 690 700
GRGPVATALI QRGTLHIGDS IVAGSSYGRV RAMINDQGES VDEAAPATPV
710 720 730 740 750
QVLGLTSVPG AGDNFLVVDD DRKARQIAEK REARMRAAQQ ARSSRRKTLD
760 770 780 790 800
QLFEQLEKGE TEELLLILKG DGAGSVEALE DALAKIDVGD EVDLRVIDRG
810 820 830 840 850
VGAITETNVS LAAASNAVIV GFNVRPTAHA QRMADEENVD IRYYSVIYDA
860 870 880 890 900
IDEIEAALRG MLKPIYEEKA MGTAEIRQIF RSSKVGTIAG CMITDGTIRR
910 920 930 940 950
HAKARLVRDG VVVQETEINT LQREKDAVTE VREGYECGLT LTNYSDIHVG
960
DEVQCYEMVE KPRD
Length:964
Mass (Da):101,394
Last modified:September 13, 2004 - v1
Checksum:i9552FDDDAB499C4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83240.1.
RefSeqiYP_056198.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT83240; AAT83240; PPA1493.
GeneIDi2931981.
KEGGipac:PPA1493.
PATRICi23037759. VBIProAcn64440_1538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83240.1 .
RefSeqi YP_056198.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6A7M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA1493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT83240 ; AAT83240 ; PPA1493 .
GeneIDi 2931981.
KEGGi pac:PPA1493.
PATRICi 23037759. VBIProAcn64440_1538.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-1515-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiIF2_PROAC
AccessioniPrimary (citable) accession number: Q6A7M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3