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Q6A7M5

- IF2_PROAC

UniProt

Q6A7M5 - IF2_PROAC

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Protein

Translation initiation factor IF-2

Gene
infB, PPA1493
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi467 – 4748GTP By similarity
Nucleotide bindingi517 – 5215GTP By similarity
Nucleotide bindingi571 – 5744GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:GHO9-1515-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:PPA1493
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Translation initiation factor IF-2UniRule annotationPRO_0000228227Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1493.

Structurei

3D structure databases

ProteinModelPortaliQ6A7M5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini458 – 629172tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni467 – 4748G1 By similarity
Regioni492 – 4965G2 By similarity
Regioni517 – 5204G3 By similarity
Regioni571 – 5744G4 By similarity
Regioni607 – 6093G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A7M5-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVRVYELA KELGLSSKQL LGKLNDMGEF VRSASSTIEA PVVRRLRDQI    50
GSAEPADDAK AAKPAARKSQ TSSKKTSKET TTAKPAPGPK PGPGPKPTPG 100
PRPGSSSGPK PGRSSAARTS ATPRPGLIKS SGASSQQEPP AAKPESKPTP 150
KPGQNVPKPH APAPKPKPGA PSKSPKPGAR PGPRPGGSAG LPSAARPGPR 200
PGAGRRTGAP RPGNNPFASS QGMGQSRHRS EGGQRSGGSR SGQGERMPRP 250
GGSQGSRGGS GMPRPNPAMM PKHQSSQIGQ ATTGRGGRGG GRGRGGSRGS 300
GFGGGFGGGP RGPIGGGRGG RGGRGTQGAF GRGGGGRRGR KSRKQRRQEF 350
DEMQAPLVGG VRVRKGNGET VRLRRGASLT DLAEKINAEP AQLVQVLFNL 400
GEMVTATQSV SDDTLEILGG ELNYQIQVVS PEDEDRELLE SFDLEFGEDE 450
GDDSDLVARP PVVTVMGHVD HGKTKLLDAL RHTDVVKGEA GGITQAIGAY 500
QVQTEVDDAE RAITFIDTPG HEAFTAMRAR GAQSTDIAVL VVAADDGVMP 550
QTVEALNHAK AADVPIVVAV NKIDKPEADP DKVRGQLTEY GLVPEEYGGD 600
TMFVNVSART HEGLDDLLEA IVLTADAALD LRANPDMAAQ GVAIEAHLDK 650
GRGPVATALI QRGTLHIGDS IVAGSSYGRV RAMINDQGES VDEAAPATPV 700
QVLGLTSVPG AGDNFLVVDD DRKARQIAEK REARMRAAQQ ARSSRRKTLD 750
QLFEQLEKGE TEELLLILKG DGAGSVEALE DALAKIDVGD EVDLRVIDRG 800
VGAITETNVS LAAASNAVIV GFNVRPTAHA QRMADEENVD IRYYSVIYDA 850
IDEIEAALRG MLKPIYEEKA MGTAEIRQIF RSSKVGTIAG CMITDGTIRR 900
HAKARLVRDG VVVQETEINT LQREKDAVTE VREGYECGLT LTNYSDIHVG 950
DEVQCYEMVE KPRD 964
Length:964
Mass (Da):101,394
Last modified:September 13, 2004 - v1
Checksum:i9552FDDDAB499C4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT83240.1.
RefSeqiYP_056198.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT83240; AAT83240; PPA1493.
GeneIDi2931981.
KEGGipac:PPA1493.
PATRICi23037759. VBIProAcn64440_1538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT83240.1 .
RefSeqi YP_056198.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6A7M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA1493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT83240 ; AAT83240 ; PPA1493 .
GeneIDi 2931981.
KEGGi pac:PPA1493.
PATRICi 23037759. VBIProAcn64440_1538.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-1515-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiIF2_PROAC
AccessioniPrimary (citable) accession number: Q6A7M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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