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Q6A7M5

- IF2_PROAC

UniProt

Q6A7M5 - IF2_PROAC

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Protein
Translation initiation factor IF-2
Gene
infB, PPA1493
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi467 – 4748GTP By similarity
Nucleotide bindingi517 – 5215GTP By similarity
Nucleotide bindingi571 – 5744GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPACN267747:GHO9-1515-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2
    Gene namesi
    Name:infB
    Ordered Locus Names:PPA1493
    OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
    Taxonomic identifieri267747 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
    ProteomesiUP000000603: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 964964Translation initiation factor IF-2UniRule annotation
    PRO_0000228227Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267747.PPA1493.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6A7M5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini458 – 629172tr-type G
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni467 – 4748G1 By similarity
    Regioni492 – 4965G2 By similarity
    Regioni517 – 5204G3 By similarity
    Regioni571 – 5744G4 By similarity
    Regioni607 – 6093G5 By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiNPDMDAQ.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6A7M5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVRVYELA KELGLSSKQL LGKLNDMGEF VRSASSTIEA PVVRRLRDQI    50
    GSAEPADDAK AAKPAARKSQ TSSKKTSKET TTAKPAPGPK PGPGPKPTPG 100
    PRPGSSSGPK PGRSSAARTS ATPRPGLIKS SGASSQQEPP AAKPESKPTP 150
    KPGQNVPKPH APAPKPKPGA PSKSPKPGAR PGPRPGGSAG LPSAARPGPR 200
    PGAGRRTGAP RPGNNPFASS QGMGQSRHRS EGGQRSGGSR SGQGERMPRP 250
    GGSQGSRGGS GMPRPNPAMM PKHQSSQIGQ ATTGRGGRGG GRGRGGSRGS 300
    GFGGGFGGGP RGPIGGGRGG RGGRGTQGAF GRGGGGRRGR KSRKQRRQEF 350
    DEMQAPLVGG VRVRKGNGET VRLRRGASLT DLAEKINAEP AQLVQVLFNL 400
    GEMVTATQSV SDDTLEILGG ELNYQIQVVS PEDEDRELLE SFDLEFGEDE 450
    GDDSDLVARP PVVTVMGHVD HGKTKLLDAL RHTDVVKGEA GGITQAIGAY 500
    QVQTEVDDAE RAITFIDTPG HEAFTAMRAR GAQSTDIAVL VVAADDGVMP 550
    QTVEALNHAK AADVPIVVAV NKIDKPEADP DKVRGQLTEY GLVPEEYGGD 600
    TMFVNVSART HEGLDDLLEA IVLTADAALD LRANPDMAAQ GVAIEAHLDK 650
    GRGPVATALI QRGTLHIGDS IVAGSSYGRV RAMINDQGES VDEAAPATPV 700
    QVLGLTSVPG AGDNFLVVDD DRKARQIAEK REARMRAAQQ ARSSRRKTLD 750
    QLFEQLEKGE TEELLLILKG DGAGSVEALE DALAKIDVGD EVDLRVIDRG 800
    VGAITETNVS LAAASNAVIV GFNVRPTAHA QRMADEENVD IRYYSVIYDA 850
    IDEIEAALRG MLKPIYEEKA MGTAEIRQIF RSSKVGTIAG CMITDGTIRR 900
    HAKARLVRDG VVVQETEINT LQREKDAVTE VREGYECGLT LTNYSDIHVG 950
    DEVQCYEMVE KPRD 964
    Length:964
    Mass (Da):101,394
    Last modified:September 13, 2004 - v1
    Checksum:i9552FDDDAB499C4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017283 Genomic DNA. Translation: AAT83240.1.
    RefSeqiYP_056198.1. NC_006085.1.

    Genome annotation databases

    EnsemblBacteriaiAAT83240; AAT83240; PPA1493.
    GeneIDi2931981.
    KEGGipac:PPA1493.
    PATRICi23037759. VBIProAcn64440_1538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017283 Genomic DNA. Translation: AAT83240.1 .
    RefSeqi YP_056198.1. NC_006085.1.

    3D structure databases

    ProteinModelPortali Q6A7M5.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 267747.PPA1493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT83240 ; AAT83240 ; PPA1493 .
    GeneIDi 2931981.
    KEGGi pac:PPA1493.
    PATRICi 23037759. VBIProAcn64440_1538.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi NPDMDAQ.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci PACN267747:GHO9-1515-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
      Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
      Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KPA171202 / DSM 16379.

    Entry informationi

    Entry nameiIF2_PROAC
    AccessioniPrimary (citable) accession number: Q6A7M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: September 13, 2004
    Last modified: September 3, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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