Reviewed, UniProtKB/Swiss-Prot Q6A780 (DNAE2_PROAC)

Names and origin

Protein names

Recommended name:
    Error-prone DNA polymerase
    EC=2.7.7.7

Gene names

Name:	dnaE2
Ordered Locus Names:	PPA1650

Organism

Propionibacterium acnes [Complete proteome] [HAMAP]

Taxonomic identifier

1747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	1134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Cellular component	Cytoplasm
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW error-prone DNA repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1134	1134	Error-prone DNA polymerase HAMAP MF_01902		PRO_0000103387

Sequences

	Sequence		Length	Mass (Da)
	Q6A780-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 8D2F6F71B5B6D5B3	FASTA	1,134	124,661
	10 20 30 40 50 60 MSYHNPPIPW RELEGRISGR PAPHGHQESH ADQVGYRHVR KPFDRHPVRP EGPVVPYAEL 70 80 90 100 110 120 HCHSSYSFLD GASNPEDLVI RAVELGLSGL ALTDHDGLYG VVRMAEAAEA CGLSTIIGSE 130 140 150 160 170 180 LSIGVPEPQN GVADPVGSHL LVLANGPEGY RRLAEALTDA YLVEGGRKGR PVHDLDHLAE 190 200 210 220 230 240 VADGHWTVLT GCRKGAVRQG LVKGMLQAEA ELRRLVDLFG IDNVLVELTD HRAPTDSRDN 250 260 270 280 290 300 DLLAELASRH SLLTVATTAA HYAGAEQFEL ACALSAVRAR RSLDEMDGWL PPGPVARLRS 310 320 330 340 350 360 GAEMADLFSR HRDAVDNTVA VAERTAFHLK SVRPRLPDQK VPDGHTPISW LRHLVEEGRR 370 380 390 400 410 420 ACYGDDPVAK DRLATELDLI EDRGFAGYFL IVSDIVEFAQ SQGILCQGRG SAAASAVCYV 430 440 450 460 470 480 LGITVVDPVF YGLPFERFLS VLREEEPDID VDFDARRREE VIQYVYAKYG RRNAAQVADV 490 500 510 520 530 540 ITYRPRSAVR DMAKALGYSQ GQQDAWSRQM ERRSVPPLPH DPDGPEIPDD VTTLAQQVMG 550 560 570 580 590 600 LPRHLGIHSA GMVLTREPVG RICPIEPARM FGRTVLQWDK EDCAWMGLVK FDLLGLGMLS 610 620 630 640 650 660 ALSISFDLIS QHCGRFWTLA SIPRNEPGVY DMLCRGDSIG VFQVESRAQI GALPRLKPRC 670 680 690 700 710 720 FYDLAVEIGL IRPGPVQGGA VHPYIRRRTG VEPVTYPHPL LEPVLERTLG IPLFQEQLMQ 730 740 750 760 770 780 MATTVGNCTA ADADLLRRAM GSKRGVERID SLRTKLFEGM AANGIDDDTA QGIYARIESF 790 800 810 820 830 840 ANFGFAESHA LSFAGLVYTS AWIKLHYPAV FLAALLRSQP MGFYSSATLV ADARRHGVVT 850 860 870 880 890 900 RRPDVARSSV GADLELLDAC CEELGSEELE TGIDECLHDH DESEIGAFDP NRDDGDHRRD 910 920 930 940 950 960 THFAVRLGLS DVSGINIETA TRIVEERERE SFASLDDLAR RVDLSGEEVE ALALAGAFDD 970 980 990 1000 1010 1020 LVGSRRGALW QIGQINGVAP GQLDVQVVTQ PPLLPEPTQM ELLGDDLRAT GISTADHPVR 1030 1040 1050 1060 1070 1080 QVRDALNRRG VVQVDRLDGV ETRRRIEVAG VVTHRQRPGT AGGVTFLNLE DETGLLNVIV 1090 1100 1110 1120 1130 TPGAWRHYRR VARTSRALVV RGILERGDEG VMSLQADRLE ALDLSVPTKS RDFR

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017283 Genomic DNA. Translation: AAT83385.1.
RefSeq	YP_056343.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2931181.
GenomeReviews	Gene locus PPA1650 in contig AE017283_GR.
KEGG	pac:PPA1650.
NMPDR	fig|267747.1.peg.1620.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6A780.
OMA	Q6A780. MGFYSPD.
Enzyme and pathway databases
BioCyc	PACN267747:PPA1650-MON.
BRENDA	2.7.7.7. 39123.
Family and domain databases
HAMAP	MF_01902. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA_bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. PHP_N. IPR004805. PolC_alpha. [Graphical view]
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00594. polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DNAE2_PROAC

Accession

Primary (citable) accession number: Q6A780

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	September 13, 2004
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)