Q6A760 (NTPA_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase
EC=3.6.1.19

Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase

Gene names

Ordered Locus Names:

PPA1673

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Non-canonical purine NTP pyrophosphatase HAMAP MF_01405		PRO_0000178209
Regions
	Region	8 – 13	6	Substrate binding By similarity
	Region	72 – 73	2	Substrate binding By similarity
Sites
	Metal binding	43	1	Magnesium or manganese By similarity
	Metal binding	72	1	Magnesium or manganese By similarity
	Binding site	158	1	Substrate By similarity
	Binding site	180	1	Substrate By similarity
	Binding site	186	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6A760 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: B60213BC229B029C	FASTA	204	22,107
	10 20 30 40 50 60 MSRIVLASNN AKKLVELRRT FEGADTEVEI VGLSEVSDAP APEETGRTFV ENALIKARAA 70 80 90 100 110 120 AHETGLPALA DDSGLEVDAL NRMPGIRSAR WSGPHAHDER NLQLLLDQTF DLPDERRHGR 130 140 150 160 170 180 FVCAMAFVDP DGTEITKVAT MEGRIISEAR GKNGFGYDPM FVPDAQPGDL TSAEMTPEVK 190 200 DAISHRGQAV RAIVPAVVAH LEGR

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT83405.1.
RefSeq	YP_056363.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A760.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2931364.
GenomeReviews	Gene locus PPA1673 in contig AE017283_GR.
KEGG	pac:PPA1673.
NMPDR	fig|267747.1.peg.1640.
PATRIC	23038147. VBIProAcn64440_1723.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	GVYTADW.
PhylomeDB	Q6A760.
ProtClustDB	CLSK2764099.
Enzyme and pathway databases
BioCyc	PACN267747:PPA1673-MONOMER.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_PROAC

Accession

Primary (citable) accession number: Q6A760

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program