Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei105NADUniRule annotation1
Binding sitei112NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciPACN267747:G1G0Y-1896-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:PPA1740
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133871 – 327Malate dehydrogenaseAdd BLAST327

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1740

Structurei

3D structure databases

ProteinModelPortaliQ6A6Z5
SMRiQ6A6Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A6Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTPVKIAV TGAAGQICYS LLFRIASGSL LGDTPIELRL LEITPALKAL
60 70 80 90 100
EGVVMELDDC AFGNLVNIEI GDDPKKVFDG VNAAFLVGAM PRKAGMERSD
110 120 130 140 150
LLTKNGAIFT AQGKALNDVA ADDVRVLVTG NPANTNALIA ATNAVDIPNN
160 170 180 190 200
HFAALTRLDH NRAKTQLARK TGKTVNDVRH MTIWGNHSST QYPDVFHAEV
210 220 230 240 250
AGQKATNLVN EAWIENEFIP TVAKRGAAII DARGASSAAS AANATVECMR
260 270 280 290 300
DWMGSTPEGD WVSMAIPSDG SYGVPEGLIS SFPVTITNGK VEIVQGLDID
310 320
DFSRAKIDAS AKELADERDA VKELGLI
Length:327
Mass (Da):34,686
Last modified:September 13, 2004 - v1
Checksum:iFFD57E60DDA61644
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT83469.1
RefSeqiWP_002516051.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT83469; AAT83469; PPA1740
GeneIDi2933187
KEGGipac:PPA1740
PATRICifig|267747.3.peg.1795

Similar proteinsi

Entry informationi

Entry nameiMDH_CUTAK
AccessioniPrimary (citable) accession number: Q6A6Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health