Q6A6T7 (COAA_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	PPA1799

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Pantothenate kinase HAMAP MF_00215		PRO_0000325560
Regions
	Nucleotide binding	105 – 112	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6A6T7 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: D68A90492561AA20	FASTA	327	37,004
	10 20 30 40 50 60 MNLTPTTPVD DDNTEPGPFI ELSRESWAVL SDSTEIDIDE ATLDHIRGLG DPTSHRDVVE 70 80 90 100 110 120 VYRPLTQLIH LYCMHTGALF DASNNFLQLT RHGMKRTPFV IGIAGSVAVG KSTVARLLRE 130 140 150 160 170 180 LLGRSPRRPV VDLVTTDGFL YPNRVLEERE LLSRKGFPES YDRKALLRFV VDVKSGMPEV 190 200 210 220 230 240 TAPVYSHVTY DIVPNQQLVV RQPDILIIEG LNVLQPPRRR SSGTMGLALS DFFDFSVYVD 250 260 270 280 290 300 AEEADIIRWY INRFLTLRQT AFTDPHSFFG EYARMPDNEA ITIAKEIWDT INGPNLVQNV 310 320 LPTRGRATAI LHKGPDHEVR NVWIRKV

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT83526.1.
RefSeq	YP_056484.1. NC_006085.1.
3D structure databases
HSSP	HSSP built from PDB template 1ESM based on UniProtKB P0A6I3.
ProteinModelPortal	Q6A6T7.
SMR	Q6A6T7. Positions 14-327.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2932083.
GenomeReviews	Gene locus PPA1799 in contig AE017283_GR.
KEGG	pac:PPA1799.
NMPDR	fig|267747.1.peg.1761.
PATRIC	23038415. VBIProAcn64440_1857.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q6A6T7.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	PACN267747:PPA1799-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_PROAC

Accession

Primary (citable) accession number: Q6A6T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program