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Q6A6S9

- TRMB_PROAC

UniProt

Q6A6S9 - TRMB_PROAC

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, PPA1808
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031S-adenosyl-L-methionine By similarity
Binding sitei128 – 1281S-adenosyl-L-methionine By similarity
Binding sitei155 – 1551S-adenosyl-L-methionine By similarity
Active sitei178 – 1781 By similarity
Binding sitei178 – 1781S-adenosyl-L-methionine By similarity
Binding sitei182 – 1821Substrate By similarity
Binding sitei214 – 2141Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPACN267747:GHO9-1824-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:PPA1808
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171372Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1808.

Structurei

3D structure databases

ProteinModelPortaliQ6A6S9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 2554Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiMSTENEN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A6S9-1 [UniParc]FASTAAdd to Basket

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MRPDPAPLDP TDASPAQARR HQPGLGVEVS AGAHRSGDRV RRGVVSFVRR    50
SPRMNVSQQR AMNTLASTYL IDVPRDATST SVAPGSRLDL PAIFGRTAPL 100
TVEIGVGSGD VLAALAAAHP ERDFIGFEVY LPSIATTLNK LENAGASNAR 150
VIMADATAGL DHLFGPADLD ELWTFFADPW HKKRHHKRRI VNPDTARLVT 200
SRLRPGGLWR LATDWDDYAH WMLEVLSAEP LLKPVDAGPD GFSPRWPERP 250
VTRYENKGLT AGRTIHDLTW RRVDES 276
Length:276
Mass (Da):30,383
Last modified:May 29, 2007 - v2
Checksum:i8695F58D362F154D
GO

Sequence cautioni

The sequence AAT83534.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT83534.1. Different initiation.
RefSeqiYP_056492.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT83534; AAT83534; PPA1808.
GeneIDi2931436.
KEGGipac:PPA1808.
PATRICi23038433. VBIProAcn64440_1866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT83534.1 . Different initiation.
RefSeqi YP_056492.1. NC_006085.1.

3D structure databases

ProteinModelPortali Q6A6S9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA1808.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT83534 ; AAT83534 ; PPA1808 .
GeneIDi 2931436.
KEGGi pac:PPA1808.
PATRICi 23038433. VBIProAcn64440_1866.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi MSTENEN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PACN267747:GHO9-1824-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiTRMB_PROAC
AccessioniPrimary (citable) accession number: Q6A6S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 29, 2007
Last modified: June 11, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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