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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103S-adenosyl-L-methionineUniRule annotation1
Binding sitei128S-adenosyl-L-methionineUniRule annotation1
Binding sitei155S-adenosyl-L-methionineUniRule annotation1
Active sitei178By similarity1
Binding sitei178S-adenosyl-L-methionineUniRule annotation1
Binding sitei182SubstrateUniRule annotation1
Binding sitei214SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:PPA1808
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713721 – 276tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST276

Proteomic databases

PRIDEiQ6A6S9

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA1808

Structurei

3D structure databases

ProteinModelPortaliQ6A6S9
SMRiQ6A6S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 255Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A6S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDPAPLDP TDASPAQARR HQPGLGVEVS AGAHRSGDRV RRGVVSFVRR
60 70 80 90 100
SPRMNVSQQR AMNTLASTYL IDVPRDATST SVAPGSRLDL PAIFGRTAPL
110 120 130 140 150
TVEIGVGSGD VLAALAAAHP ERDFIGFEVY LPSIATTLNK LENAGASNAR
160 170 180 190 200
VIMADATAGL DHLFGPADLD ELWTFFADPW HKKRHHKRRI VNPDTARLVT
210 220 230 240 250
SRLRPGGLWR LATDWDDYAH WMLEVLSAEP LLKPVDAGPD GFSPRWPERP
260 270
VTRYENKGLT AGRTIHDLTW RRVDES
Length:276
Mass (Da):30,383
Last modified:May 29, 2007 - v2
Checksum:i8695F58D362F154D
GO

Sequence cautioni

The sequence AAT83534 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT83534.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiAAT83534; AAT83534; PPA1808
KEGGipac:PPA1808

Similar proteinsi

Entry informationi

Entry nameiTRMB_CUTAK
AccessioniPrimary (citable) accession number: Q6A6S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health