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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PPA1869
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196231 – 497Glutamate--tRNA ligaseAdd BLAST497

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi267747.PPA1869

Structurei

3D structure databases

ProteinModelPortaliQ6A6M1
SMRiQ6A6M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 23"HIGH" regionUniRule annotationAdd BLAST11
Motifi253 – 257"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A6M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLHPARTR VAPSPTGDPH VGTAYMALFD KAWAQRTGGQ FVLRIEDTDR
60 70 80 90 100
TRLVADSEDQ IYQTLEWLGL SPDESPLVGG PYEPYKQSER LDTYKPLVEK
110 120 130 140 150
LIESGHAYRC WCSQERLKQL REERAAAKSP ETGYDRMCLG MSKEERAKLP
160 170 180 190 200
GFTETPVVRM LIPEDVDLEF DDLIRGTVRA PRPDDQVILK ADGFPTYHMA
210 220 230 240 250
VVVDDHLMGI DTVVRGEEWI SSTPKHLLLY KWLGWEAPKF AHMPLLRNTD
260 270 280 290 300
KSKISKRKNP AARLMWFREQ GYLPEALRNF LQLLAYPTVA EGQEMEDFDS
310 320 330 340 350
FVSRFDWGNV STGGPVFDVT KLDWLNGQYI RSLDAEVLTD RVLDYADQMC
360 370 380 390 400
QARHVLGRDL TQEDRCVIHA AMPLVRERLT LLSEALPKLA FLLTDDDALV
410 420 430 440 450
FDEDSVAKLK AGADDIQHAA VEVLKGLDDF SADAIQAALR ARLCDEMGIK
460 470 480 490
PRLAFAPVRV AVTGSRVSPP LFEAMEILGK ESTLRRMQRF EAEIDQK
Length:497
Mass (Da):56,311
Last modified:September 13, 2004 - v1
Checksum:i9C947D58F2D34B9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT83592.1
RefSeqiWP_002516065.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT83592; AAT83592; PPA1869
GeneIDi2933042
KEGGipac:PPA1869

Similar proteinsi

Entry informationi

Entry nameiSYE_CUTAK
AccessioniPrimary (citable) accession number: Q6A6M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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