Q6A655 (DEOC2_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase 2
Short name=DERA 2
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 2
Phosphodeoxyriboaldolase 2
Short name=Deoxyriboaldolase 2

Gene names

Name:	deoC2
Ordered Locus Names:	PPA2045

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Deoxyribose-phosphate aldolase 2 HAMAP MF_00114		PRO_0000231560
Sites
	Active site	157	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	187	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6A655 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: C26A671745B96D6B	FASTA	224	23,009
	10 20 30 40 50 60 MSSAPLSATE LAGMIDHTLL TPEATHNDVA KLVADAKKYG TWSVCVSPSM LPLNLDMGDV 70 80 90 100 110 120 HLAVVCGFPS GKHTSAVKAA EAREAIAAGA EEVDMVINLG LVKEGRWEDV TADIAAVKQA 130 140 150 160 170 180 VPDPKILKVI IESAVLTDDE IVRACQAAEK AGADFVKTST GFHPRGGASV EAVKVMADTV 190 200 210 220 GGRLGVKASG GIRDYQTACA MVEAGATRLG VSSTAKILAG APTE

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed: 15286373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT83758.1.
RefSeq	YP_056716.1. NC_006085.1.
3D structure databases
ProteinModelPortal	Q6A655.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2932715.
GenomeReviews	Gene locus PPA2045 in contig AE017283_GR.
KEGG	pac:PPA2045.
NMPDR	fig|267747.1.peg.1993.
PATRIC	23038903. VBIProAcn64440_2093.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	CGFPSGK.
PhylomeDB	Q6A655.
ProtClustDB	PRK00507.
Enzyme and pathway databases
BioCyc	PACN267747:PPA2045-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC2_PROAC

Accession

Primary (citable) accession number: Q6A655

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program