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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPACN267747:G1G0Y-2307-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:PPA2128
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002420671 – 556Arginine--tRNA ligaseAdd BLAST556

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi267747.PPA2128

Structurei

3D structure databases

ProteinModelPortaliQ6A5X8
SMRiQ6A5X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi117 – 127"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247212
KOiK01887
OMAiALCVFFD

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A5X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPSRLAA RIESAIGVDP QLRPATKPQF GHFQSNVALR LAKEEKRPPR
60 70 80 90 100
DVAADIVAKL DIEDLCETPE IAGPGFINLR LRADVLARVA SDFVTDPNAG
110 120 130 140 150
IAQAEKPERV VIDYSAPNVA KQMHVGHLRS TIIGDCFNRV LSAQGHTVIP
160 170 180 190 200
QNHIGDWGTQ FGMLIEYIVE KRMDVEDFDL SGVEQLYQDS KKTFDADPQF
210 220 230 240 250
ADRARRRVVK LQGGDAETLR IWRTLIDISL EGFNATYSRL SVLLTDEDVA
260 270 280 290 300
GESSYNDDLP RVVDELVADG LAVEDNGALC VFVEGQDAPM IVRKRDGGFG
310 320 330 340 350
YDATDLAAIR RRVGKLKADR IIYVTDVRQS HHFEVLFQVA RMAGFLPDDV
360 370 380 390 400
EAEHVGYGMV LGPDGRPFKT REGGTVSLSD LLDEAETHAA PNIALAAIKY
410 420 430 440 450
ADLSNGLQKD YVFDAERMVQ TTGDTGPYLQ YAHARVSQIL RKAAAEANPN
460 470 480 490 500
VDPEADLDAM DWGRISVLDE PAEQQLALLL SRFGEIVEVV ATDLTPHKLC
510 520 530 540 550
TYLYELAGAY SVFYEQCPVL RSTGEVRGSR LALCAATRRV LGRGLDLLGI

DAPDRM
Length:556
Mass (Da):61,178
Last modified:September 13, 2004 - v1
Checksum:i700CFFC132291245
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT83835.1
RefSeqiWP_011183995.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT83835; AAT83835; PPA2128
GeneIDi2932484
KEGGipac:PPA2128
PATRICifig|267747.3.peg.2182

Similar proteinsi

Entry informationi

Entry nameiSYR_CUTAK
AccessioniPrimary (citable) accession number: Q6A5X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 13, 2004
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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