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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei369 – 3691Proton donorUniRule annotation
Active sitei400 – 4001UniRule annotation
Active sitei524 – 5241UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPACN267747:GHO9-2137-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:PPA2131
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Glucose-6-phosphate isomerasePRO_0000180707Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA2131.

Structurei

3D structure databases

ProteinModelPortaliQ6A5X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A5X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLIDATST PAWGTLSGLK SRFADGPHKL RRLFDADPHR AERYTLDVAD
60 70 80 90 100
LHVDLSKNLL TDEIRDALLE LAAQMRVTER RDAMYAGEHI NVTEDRAVLH
110 120 130 140 150
TALRRSRTDE LHVDGQDAVA DVHEVLDKIY AFADKVRSGE WKGVTGKPIR
160 170 180 190 200
TVINVGIGGS DLGPVMAYEA LKPYVKDGLE CRFISNIDPT DAAVKTADLD
210 220 230 240 250
PETTLVIIAS KTFTTLETLT NARCVRAWLL DGLVAAGAIS DTEQARRDAV
260 270 280 290 300
AKHFVAVSTA LDKVEEFGID PVNAFGFWSW VGGRYSVDSA VGTSLAVAIG
310 320 330 340 350
PKGFEDFLAG FHAVDEHFAT AEPERNVPLF MGLLNIWYTN FWDAHSHAVL
360 370 380 390 400
PYSQYLHRFP AYLQQLTMES NGKSVRWDGS AVTTDTGEIF WGEPGTNGQH
410 420 430 440 450
AFYQLIHQGT RVIPADFIAV ANPVHPTKDG GTDVHELFLS NFFAQTAALA
460 470 480 490 500
FGKTADEVRA EGTDEAIVPA RVFAGDRPTT SIMADELSPK VLGELIALYE
510 520 530 540 550
HITFVQGVVW GIDSFDQWGV ELGKKLALQI APAVSGNDEA LATQDPSTQG
560
LVTWYREHRR
Length:560
Mass (Da):61,457
Last modified:September 13, 2004 - v1
Checksum:i7DB374E911211615
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83838.1.
RefSeqiYP_056796.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT83838; AAT83838; PPA2131.
KEGGipac:PPA2131.
PATRICi23039089. VBIProAcn64440_2185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83838.1.
RefSeqiYP_056796.1. NC_006085.1.

3D structure databases

ProteinModelPortaliQ6A5X5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267747.PPA2131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT83838; AAT83838; PPA2131.
KEGGipac:PPA2131.
PATRICi23039089. VBIProAcn64440_2185.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciPACN267747:GHO9-2137-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiG6PI_PROAC
AccessioniPrimary (citable) accession number: Q6A5X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: September 13, 2004
Last modified: April 1, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.