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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA), 6-phosphofructokinase (PPA2267), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei369Proton donorUniRule annotation1
Active sitei400UniRule annotation1
Active sitei524UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:PPA2131
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807071 – 560Glucose-6-phosphate isomeraseAdd BLAST560

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA2131

Structurei

3D structure databases

ProteinModelPortaliQ6A5X5
SMRiQ6A5X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiTNSQHAF

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A5X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLIDATST PAWGTLSGLK SRFADGPHKL RRLFDADPHR AERYTLDVAD
60 70 80 90 100
LHVDLSKNLL TDEIRDALLE LAAQMRVTER RDAMYAGEHI NVTEDRAVLH
110 120 130 140 150
TALRRSRTDE LHVDGQDAVA DVHEVLDKIY AFADKVRSGE WKGVTGKPIR
160 170 180 190 200
TVINVGIGGS DLGPVMAYEA LKPYVKDGLE CRFISNIDPT DAAVKTADLD
210 220 230 240 250
PETTLVIIAS KTFTTLETLT NARCVRAWLL DGLVAAGAIS DTEQARRDAV
260 270 280 290 300
AKHFVAVSTA LDKVEEFGID PVNAFGFWSW VGGRYSVDSA VGTSLAVAIG
310 320 330 340 350
PKGFEDFLAG FHAVDEHFAT AEPERNVPLF MGLLNIWYTN FWDAHSHAVL
360 370 380 390 400
PYSQYLHRFP AYLQQLTMES NGKSVRWDGS AVTTDTGEIF WGEPGTNGQH
410 420 430 440 450
AFYQLIHQGT RVIPADFIAV ANPVHPTKDG GTDVHELFLS NFFAQTAALA
460 470 480 490 500
FGKTADEVRA EGTDEAIVPA RVFAGDRPTT SIMADELSPK VLGELIALYE
510 520 530 540 550
HITFVQGVVW GIDSFDQWGV ELGKKLALQI APAVSGNDEA LATQDPSTQG
560
LVTWYREHRR
Length:560
Mass (Da):61,457
Last modified:September 13, 2004 - v1
Checksum:i7DB374E911211615
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT83838.1
RefSeqiWP_002530768.1, NC_006085.1

Genome annotation databases

EnsemblBacteriaiAAT83838; AAT83838; PPA2131
GeneIDi2932472
KEGGipac:PPA2131

Similar proteinsi

Entry informationi

Entry nameiG6PI_CUTAK
AccessioniPrimary (citable) accession number: Q6A5X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: September 13, 2004
Last modified: June 20, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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