Q6A5N5 (UPPP_PROAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	PPA2224

Organism

Propionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]

Taxonomic identifier

267747 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium › Propionibacterium acnes

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151177
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	193 – 213	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	259 – 279	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6A5N5 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: A3849D29B46F3A88	FASTA	284	30,279
	10 20 30 40 50 60 MNWLHAIILG IVEGITEFLP VSSTGHLRIV EKLLGYDIQG AGITAFTAII QVGAIIAAIL 70 80 90 100 110 120 YFWSDIVRIV VAWCKGLAHK EDRDDPDYTL GWGIILGSIP VGVVGLVFKD AIETTLSSLW 130 140 150 160 170 180 VVAIALILWS GVMWLGDRQL GLNRGMKEIG IVDAIVIGCF QALAPLFPGI SRSGATISAG 190 200 210 220 230 240 LFRKFDRATA TRLSFFMGIP ALVAAGIYES VSAASDISIA QGGAVAIGWG PTILATVVSL 250 260 270 280 IVAYVSIAWL LKFVSSNKFT GFMWYRVVVG LIIIGLILSN VVTA

References

[1]

"The complete genome sequence of Propionibacterium acnes, a commensal of human skin." Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G. Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017283 Genomic DNA. Translation: AAT83928.1.
RefSeq	YP_056886.1. NC_006085.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	267747.PPA2224.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT83928; AAT83928; PPA2224.
GeneID	2931906.
KEGG	pac:PPA2224.
PATRIC	23039307. VBIProAcn64440_2288.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	MFAVIAY.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	PACN267747:GHO9-2233-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_PROAC

Accession

Primary (citable) accession number: Q6A5N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program