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Q6A5N5

- UPPP_PROAC

UniProt

Q6A5N5 - UPPP_PROAC

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciPACN267747:GHO9-2233-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:PPA2224
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei43 – 6321HelicalUniRule annotationAdd
BLAST
Transmembranei88 – 10821HelicalUniRule annotationAdd
BLAST
Transmembranei116 – 13621HelicalUniRule annotationAdd
BLAST
Transmembranei149 – 16921HelicalUniRule annotationAdd
BLAST
Transmembranei193 – 21321HelicalUniRule annotationAdd
BLAST
Transmembranei225 – 24521HelicalUniRule annotationAdd
BLAST
Transmembranei259 – 27921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Undecaprenyl-diphosphatasePRO_0000151177Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA2224.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiPVLNACG.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A5N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNWLHAIILG IVEGITEFLP VSSTGHLRIV EKLLGYDIQG AGITAFTAII
60 70 80 90 100
QVGAIIAAIL YFWSDIVRIV VAWCKGLAHK EDRDDPDYTL GWGIILGSIP
110 120 130 140 150
VGVVGLVFKD AIETTLSSLW VVAIALILWS GVMWLGDRQL GLNRGMKEIG
160 170 180 190 200
IVDAIVIGCF QALAPLFPGI SRSGATISAG LFRKFDRATA TRLSFFMGIP
210 220 230 240 250
ALVAAGIYES VSAASDISIA QGGAVAIGWG PTILATVVSL IVAYVSIAWL
260 270 280
LKFVSSNKFT GFMWYRVVVG LIIIGLILSN VVTA
Length:284
Mass (Da):30,279
Last modified:September 13, 2004 - v1
Checksum:iA3849D29B46F3A88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83928.1.
RefSeqiYP_056886.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT83928; AAT83928; PPA2224.
GeneIDi2931906.
KEGGipac:PPA2224.
PATRICi23039307. VBIProAcn64440_2288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83928.1 .
RefSeqi YP_056886.1. NC_006085.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267747.PPA2224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT83928 ; AAT83928 ; PPA2224 .
GeneIDi 2931906.
KEGGi pac:PPA2224.
PATRICi 23039307. VBIProAcn64440_2288.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi PVLNACG.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-2233-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiUPPP_PROAC
AccessioniPrimary (citable) accession number: Q6A5N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3