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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:PPA2224
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaePropionibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei43 – 63HelicalUniRule annotationAdd BLAST21
Transmembranei88 – 108HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei149 – 169HelicalUniRule annotationAdd BLAST21
Transmembranei193 – 213HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511771 – 284Undecaprenyl-diphosphataseAdd BLAST284

Interactioni

Protein-protein interaction databases

STRINGi267747.PPA2224.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIFAWLRI.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A5N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWLHAIILG IVEGITEFLP VSSTGHLRIV EKLLGYDIQG AGITAFTAII
60 70 80 90 100
QVGAIIAAIL YFWSDIVRIV VAWCKGLAHK EDRDDPDYTL GWGIILGSIP
110 120 130 140 150
VGVVGLVFKD AIETTLSSLW VVAIALILWS GVMWLGDRQL GLNRGMKEIG
160 170 180 190 200
IVDAIVIGCF QALAPLFPGI SRSGATISAG LFRKFDRATA TRLSFFMGIP
210 220 230 240 250
ALVAAGIYES VSAASDISIA QGGAVAIGWG PTILATVVSL IVAYVSIAWL
260 270 280
LKFVSSNKFT GFMWYRVVVG LIIIGLILSN VVTA
Length:284
Mass (Da):30,279
Last modified:September 13, 2004 - v1
Checksum:iA3849D29B46F3A88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83928.1.
RefSeqiWP_002516473.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT83928; AAT83928; PPA2224.
GeneIDi2931906.
KEGGipac:PPA2224.
PATRICi23039307. VBIProAcn64440_2288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT83928.1.
RefSeqiWP_002516473.1. NC_006085.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267747.PPA2224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT83928; AAT83928; PPA2224.
GeneIDi2931906.
KEGGipac:PPA2224.
PATRICi23039307. VBIProAcn64440_2288.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIFAWLRI.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_PROAC
AccessioniPrimary (citable) accession number: Q6A5N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.