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Q6A5N5 (UPPP_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:PPA2224
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151177

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6A5N5 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: A3849D29B46F3A88

FASTA28430,279
        10         20         30         40         50         60 
MNWLHAIILG IVEGITEFLP VSSTGHLRIV EKLLGYDIQG AGITAFTAII QVGAIIAAIL 

        70         80         90        100        110        120 
YFWSDIVRIV VAWCKGLAHK EDRDDPDYTL GWGIILGSIP VGVVGLVFKD AIETTLSSLW 

       130        140        150        160        170        180 
VVAIALILWS GVMWLGDRQL GLNRGMKEIG IVDAIVIGCF QALAPLFPGI SRSGATISAG 

       190        200        210        220        230        240 
LFRKFDRATA TRLSFFMGIP ALVAAGIYES VSAASDISIA QGGAVAIGWG PTILATVVSL 

       250        260        270        280 
IVAYVSIAWL LKFVSSNKFT GFMWYRVVVG LIIIGLILSN VVTA 

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT83928.1.
RefSeqYP_056886.1. NC_006085.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267747.PPA2224.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT83928; AAT83928; PPA2224.
GeneID2931906.
KEGGpac:PPA2224.
PATRIC23039307. VBIProAcn64440_2288.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAPVLNACG.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycPACN267747:GHO9-2233-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PROAC
AccessionPrimary (citable) accession number: Q6A5N5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families