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Q6A555 (TXND8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin domain-containing protein 8
Alternative name(s):
Spermatid-specific thioredoxin-3
Short name=Sptrx-3
Thioredoxin-6
Gene names
Name:TXNDC8
Synonyms:SPTRX3, TRX6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm. Ref.1

Subcellular location

Cytoplasm. Golgi apparatus Ref.1.

Tissue specificity

Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). Ref.1

Miscellaneous

Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis.

Sequence similarities

Belongs to the thioredoxin family.

Contains 1 thioredoxin domain.

Sequence caution

The sequence CAI14069.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6A555-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6A555-2)

The sequence of this isoform differs from the canonical sequence as follows:
     108-127: IFEFCGADAKKLEAKTQELM → CLADDGNE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Thioredoxin domain-containing protein 8
PRO_0000120162

Regions

Domain1 – 9292Thioredoxin

Amino acid modifications

Disulfide bond32 ↔ 35Redox-active By similarity

Natural variations

Alternative sequence108 – 12720IFEFC…TQELM → CLADDGNE in isoform 2.
VSP_014333
Natural variant601N → H.
Corresponds to variant rs7041938 [ dbSNP | Ensembl ].
VAR_057353

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 94BBF008A82CBD8F

FASTA12714,575
        10         20         30         40         50         60 
MVQIIKDTNE FKTFLTAAGH KLAVVQFSSK RCGPCKRMFP VFHAMSVKYQ NVFFANVDVN 

        70         80         90        100        110        120 
NSPELAETCH IKTIPTFQMF KKSQKVTLFS RIKRIICCYR SGFMSNLIFE FCGADAKKLE 


AKTQELM 

« Hide

Isoform 2 [UniParc].

Checksum: 6F205772109C5ECF
Show »

FASTA11513,138

References

« Hide 'large scale' references
[1]"Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis."
Jimenez A., Zu W., Rawe V.Y., Pelto-Huikko M., Flickinger C.J., Sutovsky P., Gustafsson J.-A., Oko R., Miranda-Vizuete A.
J. Biol. Chem. 279:34971-34982(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF305830 mRNA. Translation: AAQ14501.1.
AL158158 Genomic DNA. Translation: CAI14069.1. Sequence problems.
BC130549 mRNA. Translation: AAI30550.1.
BC130551 mRNA. Translation: AAI30552.1.
CCDSCCDS35104.1. [Q6A555-2]
RefSeqNP_001003936.1. NM_001003936.3. [Q6A555-2]
NP_001273875.1. NM_001286946.1.
XP_005251936.1. XM_005251879.1. [Q6A555-1]
UniGeneHs.147064.

3D structure databases

ProteinModelPortalQ6A555.
SMRQ6A555. Positions 1-127.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000363634.

PTM databases

PhosphoSiteQ6A555.

Polymorphism databases

DMDM68566177.

Proteomic databases

PaxDbQ6A555.
PRIDEQ6A555.

Protocols and materials databases

DNASU255220.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374510; ENSP00000363634; ENSG00000204193. [Q6A555-2]
ENST00000374511; ENSP00000363635; ENSG00000204193. [Q6A555-1]
GeneID255220.
KEGGhsa:255220.
UCSCuc004bes.3. human. [Q6A555-2]

Organism-specific databases

CTD255220.
GeneCardsGC09M113065.
HGNCHGNC:31454. TXNDC8.
HPAHPA046844.
neXtProtNX_Q6A555.
PharmGKBPA134935003.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000292977.
HOVERGENHBG009243.
InParanoidQ6A555.
OMACGADAKK.
OrthoDBEOG79SF05.
PhylomeDBQ6A555.
TreeFamTF321403.

Gene expression databases

ArrayExpressQ6A555.
BgeeQ6A555.
CleanExHS_TXNDC8.
GenevestigatorQ6A555.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERPTHR10438. PTHR10438. 1 hit.
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi255220.
NextBio92519.
PROQ6A555.

Entry information

Entry nameTXND8_HUMAN
AccessionPrimary (citable) accession number: Q6A555
Secondary accession number(s): A1L4I2, A6NDK7, Q5T934
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM