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Protein

Thioredoxin domain-containing protein 8

Gene

TXNDC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.

Miscellaneous

Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 8
Alternative name(s):
Spermatid-specific thioredoxin-3
Short name:
Sptrx-3
Thioredoxin-6
Gene namesi
Name:TXNDC8
Synonyms:SPTRX3, TRX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000204193.10.
HGNCiHGNC:31454. TXNDC8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204193.
PharmGKBiPA134935003.

Polymorphism and mutation databases

BioMutaiTXNDC8.
DMDMi68566177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201621 – 127Thioredoxin domain-containing protein 8Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 35Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6A555.
PeptideAtlasiQ6A555.
PRIDEiQ6A555.

PTM databases

PhosphoSitePlusiQ6A555.

Expressioni

Tissue specificityi

Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000204193.
CleanExiHS_TXNDC8.
ExpressionAtlasiQ6A555. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363634.

Structurei

3D structure databases

ProteinModelPortaliQ6A555.
SMRiQ6A555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92ThioredoxinAdd BLAST92

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000292977.
HOVERGENiHBG009243.
InParanoidiQ6A555.
OMAiPVFHAMS.
OrthoDBiEOG091G01FG.
PhylomeDBiQ6A555.
TreeFamiTF321403.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6A555-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQIIKDTNE FKTFLTAAGH KLAVVQFSSK RCGPCKRMFP VFHAMSVKYQ
60 70 80 90 100
NVFFANVDVN NSPELAETCH IKTIPTFQMF KKSQKVTLFS RIKRIICCYR
110 120
SGFMSNLIFE FCGADAKKLE AKTQELM
Length:127
Mass (Da):14,575
Last modified:July 5, 2005 - v2
Checksum:i94BBF008A82CBD8F
GO
Isoform 2 (identifier: Q6A555-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-127: IFEFCGADAKKLEAKTQELM → CLADDGNE

Show »
Length:115
Mass (Da):13,138
Checksum:i6F205772109C5ECF
GO

Sequence cautioni

Q6A555: The sequence CAI14069 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05735360N → H. Corresponds to variant dbSNP:rs7041938Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014333108 – 127IFEFC…TQELM → CLADDGNE in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305830 mRNA. Translation: AAQ14501.1.
AL158158 Genomic DNA. Translation: CAI14069.1. Sequence problems.
BC130549 mRNA. Translation: AAI30550.1.
BC130551 mRNA. Translation: AAI30552.1.
CCDSiCCDS35104.1. [Q6A555-2]
RefSeqiNP_001003936.1. NM_001003936.3. [Q6A555-2]
NP_001273875.1. NM_001286946.1.
XP_016870070.1. XM_017014581.1. [Q6A555-1]
UniGeneiHs.147064.

Genome annotation databases

EnsembliENST00000374510; ENSP00000363634; ENSG00000204193. [Q6A555-2]
ENST00000374511; ENSP00000363635; ENSG00000204193. [Q6A555-1]
GeneIDi255220.
KEGGihsa:255220.
UCSCiuc004bes.5. human. [Q6A555-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTXND8_HUMAN
AccessioniPrimary (citable) accession number: Q6A555
Secondary accession number(s): A1L4I2, A6NDK7, Q5T934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 25, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families