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Q6A555

- TXND8_HUMAN

UniProt

Q6A555 - TXND8_HUMAN

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Protein
Thioredoxin domain-containing protein 8
Gene
TXNDC8, SPTRX3, TRX6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.1 Publication

GO - Biological processi

  1. acrosome assembly Source: Ensembl
  2. cell redox homeostasis Source: InterPro
  3. glycerol ether metabolic process Source: InterPro
  4. multicellular organismal development Source: UniProtKB-KW
  5. spermatogenesis Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 8
Alternative name(s):
Spermatid-specific thioredoxin-3
Short name:
Sptrx-3
Thioredoxin-6
Gene namesi
Name:TXNDC8
Synonyms:SPTRX3, TRX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:31454. TXNDC8.

Subcellular locationi

Cytoplasm. Golgi apparatus 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProt
  2. acrosomal vesicle Source: Ensembl
  3. cytoplasm Source: UniProt
  4. extracellular vesicular exosome Source: UniProt
  5. sperm flagellum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Thioredoxin domain-containing protein 8
PRO_0000120162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 35Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6A555.
PRIDEiQ6A555.

PTM databases

PhosphoSiteiQ6A555.

Expressioni

Tissue specificityi

Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ6A555.
BgeeiQ6A555.
CleanExiHS_TXNDC8.
GenevestigatoriQ6A555.

Organism-specific databases

HPAiHPA046844.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363634.

Structurei

3D structure databases

ProteinModelPortaliQ6A555.
SMRiQ6A555. Positions 1-127.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292Thioredoxin
Add
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.
Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000292977.
HOVERGENiHBG009243.
InParanoidiQ6A555.
OMAiCGADAKK.
OrthoDBiEOG79SF05.
PhylomeDBiQ6A555.
TreeFamiTF321403.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6A555-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVQIIKDTNE FKTFLTAAGH KLAVVQFSSK RCGPCKRMFP VFHAMSVKYQ    50
NVFFANVDVN NSPELAETCH IKTIPTFQMF KKSQKVTLFS RIKRIICCYR 100
SGFMSNLIFE FCGADAKKLE AKTQELM 127
Length:127
Mass (Da):14,575
Last modified:July 5, 2005 - v2
Checksum:i94BBF008A82CBD8F
GO
Isoform 2 (identifier: Q6A555-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-127: IFEFCGADAKKLEAKTQELM → CLADDGNE

Show »
Length:115
Mass (Da):13,138
Checksum:i6F205772109C5ECF
GO

Sequence cautioni

The sequence CAI14069.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601N → H.
Corresponds to variant rs7041938 [ dbSNP | Ensembl ].
VAR_057353

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei108 – 12720IFEFC…TQELM → CLADDGNE in isoform 2.
VSP_014333Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305830 mRNA. Translation: AAQ14501.1.
AL158158 Genomic DNA. Translation: CAI14069.1. Sequence problems.
BC130549 mRNA. Translation: AAI30550.1.
BC130551 mRNA. Translation: AAI30552.1.
CCDSiCCDS35104.1. [Q6A555-2]
RefSeqiNP_001003936.1. NM_001003936.3. [Q6A555-2]
NP_001273875.1. NM_001286946.1.
XP_005251936.1. XM_005251879.1. [Q6A555-1]
UniGeneiHs.147064.

Genome annotation databases

EnsembliENST00000374510; ENSP00000363634; ENSG00000204193. [Q6A555-2]
ENST00000374511; ENSP00000363635; ENSG00000204193. [Q6A555-1]
GeneIDi255220.
KEGGihsa:255220.
UCSCiuc004bes.3. human. [Q6A555-2]

Polymorphism databases

DMDMi68566177.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305830 mRNA. Translation: AAQ14501.1 .
AL158158 Genomic DNA. Translation: CAI14069.1 . Sequence problems.
BC130549 mRNA. Translation: AAI30550.1 .
BC130551 mRNA. Translation: AAI30552.1 .
CCDSi CCDS35104.1. [Q6A555-2 ]
RefSeqi NP_001003936.1. NM_001003936.3. [Q6A555-2 ]
NP_001273875.1. NM_001286946.1.
XP_005251936.1. XM_005251879.1. [Q6A555-1 ]
UniGenei Hs.147064.

3D structure databases

ProteinModelPortali Q6A555.
SMRi Q6A555. Positions 1-127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000363634.

PTM databases

PhosphoSitei Q6A555.

Polymorphism databases

DMDMi 68566177.

Proteomic databases

PaxDbi Q6A555.
PRIDEi Q6A555.

Protocols and materials databases

DNASUi 255220.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374510 ; ENSP00000363634 ; ENSG00000204193 . [Q6A555-2 ]
ENST00000374511 ; ENSP00000363635 ; ENSG00000204193 . [Q6A555-1 ]
GeneIDi 255220.
KEGGi hsa:255220.
UCSCi uc004bes.3. human. [Q6A555-2 ]

Organism-specific databases

CTDi 255220.
GeneCardsi GC09M113065.
HGNCi HGNC:31454. TXNDC8.
HPAi HPA046844.
neXtProti NX_Q6A555.
PharmGKBi PA134935003.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000292977.
HOVERGENi HBG009243.
InParanoidi Q6A555.
OMAi CGADAKK.
OrthoDBi EOG79SF05.
PhylomeDBi Q6A555.
TreeFami TF321403.

Miscellaneous databases

GenomeRNAii 255220.
NextBioi 92519.
PROi Q6A555.

Gene expression databases

ArrayExpressi Q6A555.
Bgeei Q6A555.
CleanExi HS_TXNDC8.
Genevestigatori Q6A555.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
PANTHERi PTHR10438. PTHR10438. 1 hit.
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis."
    Jimenez A., Zu W., Rawe V.Y., Pelto-Huikko M., Flickinger C.J., Sutovsky P., Gustafsson J.-A., Oko R., Miranda-Vizuete A.
    J. Biol. Chem. 279:34971-34982(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lymph.

Entry informationi

Entry nameiTXND8_HUMAN
AccessioniPrimary (citable) accession number: Q6A555
Secondary accession number(s): A1L4I2, A6NDK7, Q5T934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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