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Q6A555

- TXND8_HUMAN

UniProt

Q6A555 - TXND8_HUMAN

Protein

Thioredoxin domain-containing protein 8

Gene

TXNDC8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.

    GO - Biological processi

    1. acrosome assembly Source: Ensembl
    2. cell redox homeostasis Source: InterPro
    3. glycerol ether metabolic process Source: InterPro
    4. multicellular organismal development Source: UniProtKB-KW
    5. spermatogenesis Source: UniProt

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 8
    Alternative name(s):
    Spermatid-specific thioredoxin-3
    Short name:
    Sptrx-3
    Thioredoxin-6
    Gene namesi
    Name:TXNDC8
    Synonyms:SPTRX3, TRX6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:31454. TXNDC8.

    Subcellular locationi

    Cytoplasm 1 Publication. Golgi apparatus 1 Publication

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. cytoplasm Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: UniProt
    5. sperm flagellum Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134935003.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Thioredoxin domain-containing protein 8PRO_0000120162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 35Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ6A555.
    PRIDEiQ6A555.

    PTM databases

    PhosphoSiteiQ6A555.

    Expressioni

    Tissue specificityi

    Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ6A555.
    BgeeiQ6A555.
    CleanExiHS_TXNDC8.
    GenevestigatoriQ6A555.

    Organism-specific databases

    HPAiHPA046844.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000363634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6A555.
    SMRiQ6A555. Positions 1-127.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9292ThioredoxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thioredoxin family.Curated
    Contains 1 thioredoxin domain.Curated

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000292977.
    HOVERGENiHBG009243.
    InParanoidiQ6A555.
    OMAiCGADAKK.
    OrthoDBiEOG79SF05.
    PhylomeDBiQ6A555.
    TreeFamiTF321403.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PANTHERiPTHR10438. PTHR10438. 1 hit.
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6A555-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVQIIKDTNE FKTFLTAAGH KLAVVQFSSK RCGPCKRMFP VFHAMSVKYQ    50
    NVFFANVDVN NSPELAETCH IKTIPTFQMF KKSQKVTLFS RIKRIICCYR 100
    SGFMSNLIFE FCGADAKKLE AKTQELM 127
    Length:127
    Mass (Da):14,575
    Last modified:July 5, 2005 - v2
    Checksum:i94BBF008A82CBD8F
    GO
    Isoform 2 (identifier: Q6A555-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         108-127: IFEFCGADAKKLEAKTQELM → CLADDGNE

    Show »
    Length:115
    Mass (Da):13,138
    Checksum:i6F205772109C5ECF
    GO

    Sequence cautioni

    The sequence CAI14069.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601N → H.
    Corresponds to variant rs7041938 [ dbSNP | Ensembl ].
    VAR_057353

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei108 – 12720IFEFC…TQELM → CLADDGNE in isoform 2. 2 PublicationsVSP_014333Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305830 mRNA. Translation: AAQ14501.1.
    AL158158 Genomic DNA. Translation: CAI14069.1. Sequence problems.
    BC130549 mRNA. Translation: AAI30550.1.
    BC130551 mRNA. Translation: AAI30552.1.
    CCDSiCCDS35104.1. [Q6A555-2]
    RefSeqiNP_001003936.1. NM_001003936.3. [Q6A555-2]
    NP_001273875.1. NM_001286946.1.
    XP_005251936.1. XM_005251879.1. [Q6A555-1]
    UniGeneiHs.147064.

    Genome annotation databases

    EnsembliENST00000374510; ENSP00000363634; ENSG00000204193. [Q6A555-2]
    ENST00000374511; ENSP00000363635; ENSG00000204193. [Q6A555-1]
    GeneIDi255220.
    KEGGihsa:255220.
    UCSCiuc004bes.3. human. [Q6A555-2]

    Polymorphism databases

    DMDMi68566177.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305830 mRNA. Translation: AAQ14501.1 .
    AL158158 Genomic DNA. Translation: CAI14069.1 . Sequence problems.
    BC130549 mRNA. Translation: AAI30550.1 .
    BC130551 mRNA. Translation: AAI30552.1 .
    CCDSi CCDS35104.1. [Q6A555-2 ]
    RefSeqi NP_001003936.1. NM_001003936.3. [Q6A555-2 ]
    NP_001273875.1. NM_001286946.1.
    XP_005251936.1. XM_005251879.1. [Q6A555-1 ]
    UniGenei Hs.147064.

    3D structure databases

    ProteinModelPortali Q6A555.
    SMRi Q6A555. Positions 1-127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000363634.

    PTM databases

    PhosphoSitei Q6A555.

    Polymorphism databases

    DMDMi 68566177.

    Proteomic databases

    PaxDbi Q6A555.
    PRIDEi Q6A555.

    Protocols and materials databases

    DNASUi 255220.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374510 ; ENSP00000363634 ; ENSG00000204193 . [Q6A555-2 ]
    ENST00000374511 ; ENSP00000363635 ; ENSG00000204193 . [Q6A555-1 ]
    GeneIDi 255220.
    KEGGi hsa:255220.
    UCSCi uc004bes.3. human. [Q6A555-2 ]

    Organism-specific databases

    CTDi 255220.
    GeneCardsi GC09M113065.
    HGNCi HGNC:31454. TXNDC8.
    HPAi HPA046844.
    neXtProti NX_Q6A555.
    PharmGKBi PA134935003.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000292977.
    HOVERGENi HBG009243.
    InParanoidi Q6A555.
    OMAi CGADAKK.
    OrthoDBi EOG79SF05.
    PhylomeDBi Q6A555.
    TreeFami TF321403.

    Miscellaneous databases

    GenomeRNAii 255220.
    NextBioi 92519.
    PROi Q6A555.

    Gene expression databases

    ArrayExpressi Q6A555.
    Bgeei Q6A555.
    CleanExi HS_TXNDC8.
    Genevestigatori Q6A555.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    PANTHERi PTHR10438. PTHR10438. 1 hit.
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis."
      Jimenez A., Zu W., Rawe V.Y., Pelto-Huikko M., Flickinger C.J., Sutovsky P., Gustafsson J.-A., Oko R., Miranda-Vizuete A.
      J. Biol. Chem. 279:34971-34982(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), POSSIBLE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lymph.

    Entry informationi

    Entry nameiTXND8_HUMAN
    AccessioniPrimary (citable) accession number: Q6A555
    Secondary accession number(s): A1L4I2, A6NDK7, Q5T934
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Increased levels, possibly caused by overexpression, are observed in morphologically abnormal spermatozoa from infertile men, suggesting that it may be used as a marker of aberrant spermatogenesis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3