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Protein

Solute carrier family 22 member 13

Gene

Slc22a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name:
ORCTL-3
Gene namesi
Name:Slc22a13
Synonyms:Orctl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143107. Slc22a13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 142ExtracellularSequence analysisAdd BLAST99
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 167CytoplasmicSequence analysis4
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 195ExtracellularSequence analysis7
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 251ExtracellularSequence analysis6
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 332CytoplasmicSequence analysisAdd BLAST60
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354ExtracellularSequence analysis1
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 404CytoplasmicSequence analysisAdd BLAST29
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 427ExtracellularSequence analysis2
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 452CytoplasmicSequence analysis4
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 478ExtracellularSequence analysis5
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 551CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307831 – 551Solute carrier family 22 member 13Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6A4L0.
PRIDEiQ6A4L0.

PTM databases

iPTMnetiQ6A4L0.
PhosphoSitePlusiQ6A4L0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074028.
GenevisibleiQ6A4L0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081855.

Structurei

3D structure databases

ProteinModelPortaliQ6A4L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6A4L0.
KOiK08209.
OMAiRILGMWA.
OrthoDBiEOG091G05AC.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFAQVMAE VGDFGRFQVR LTILMGIPNF LAAFFIFGQV FMVLDEAHHC
60 70 80 90 100
SVSWVKNHTF NLSAAEQLAI SIPNDTAGRP ESCLMFRPPP DSASLEDILS
110 120 130 140 150
HRFNETQACD SGWDYPENRP QSLKKEFDLV CDRKNLKKTS QSVFMAGLLV
160 170 180 190 200
GALVFGPVCD WIGRRPSLLM QVLLSGITSM ATAFVSSFEL YLALRFVLAT
210 220 230 240 250
ANAGFLLSTN VLISEWVGPS WRTQAVVLAQ SNVALGQMVL AGLAYGVRNW
260 270 280 290 300
RLLQITGTAP VLLLFFYFWV LPESPRWLLS QGRTEEAKQL VQKAALVNGR
310 320 330 340 350
PLSPELLNQL VPEKTGPSGN ALDLFRHPHL RKVTLILIAV WFVDSLVYYS
360 370 380 390 400
LSFQVGDFGL DIYVTQLIFG AVEMPGRFLS VLMMEKLGRK WSQLCTLTLA
410 420 430 440 450
GIMYIIIIFI PGDLPTVVTV LAVVGKFASA AAFTISYVYT AELFPTIIRQ
460 470 480 490 500
TGMGLVSIFS RVGGIITPLV MLLEQYHQAI PMVIFGSLPI GAGLLCALLP
510 520 530 540 550
ETRGQTLKDT LQDLEQGLPA GSHKTAPQRQ DMEALGRTSS VRVAVVKSSY

F
Length:551
Mass (Da):60,724
Last modified:July 27, 2011 - v3
Checksum:i2DAAE51ED8352724
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti402I → V in AAQ09528 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77A → T in strain: FVB/N. 1 Publication1
Natural varianti506T → I in strain: FVB/N. 1 Publication1
Natural varianti535L → S in strain: FVB/N. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529220 mRNA. Translation: AAQ09528.1.
AC055818 Genomic DNA. No translation available.
BC021449 mRNA. Translation: AAH21449.1.
CCDSiCCDS40802.1.
RefSeqiNP_598741.2. NM_133980.3.
UniGeneiMm.38775.

Genome annotation databases

EnsembliENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028.
GeneIDi102570.
KEGGimmu:102570.
UCSCiuc009sal.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529220 mRNA. Translation: AAQ09528.1.
AC055818 Genomic DNA. No translation available.
BC021449 mRNA. Translation: AAH21449.1.
CCDSiCCDS40802.1.
RefSeqiNP_598741.2. NM_133980.3.
UniGeneiMm.38775.

3D structure databases

ProteinModelPortaliQ6A4L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081855.

PTM databases

iPTMnetiQ6A4L0.
PhosphoSitePlusiQ6A4L0.

Proteomic databases

PaxDbiQ6A4L0.
PRIDEiQ6A4L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028.
GeneIDi102570.
KEGGimmu:102570.
UCSCiuc009sal.2. mouse.

Organism-specific databases

CTDi9390.
MGIiMGI:2143107. Slc22a13.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6A4L0.
KOiK08209.
OMAiRILGMWA.
OrthoDBiEOG091G05AC.
TreeFamiTF315847.

Miscellaneous databases

PROiQ6A4L0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074028.
GenevisibleiQ6A4L0. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AD_MOUSE
AccessioniPrimary (citable) accession number: Q6A4L0
Secondary accession number(s): E9QP74, Q8VC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.