Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 22 member 13

Gene

Slc22a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name:
ORCTL-3
Gene namesi
Name:Slc22a13
Synonyms:Orctl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143107. Slc22a13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Topological domaini44 – 14299ExtracellularSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Topological domaini164 – 1674CytoplasmicSequence analysis
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Topological domaini189 – 1957ExtracellularSequence analysis
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 2248CytoplasmicSequence analysis
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 2516ExtracellularSequence analysis
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 33260CytoplasmicSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Topological domaini354 – 3541ExtracellularSequence analysis
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 40429CytoplasmicSequence analysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence analysisAdd
BLAST
Topological domaini426 – 4272ExtracellularSequence analysis
Transmembranei428 – 44821HelicalSequence analysisAdd
BLAST
Topological domaini449 – 4524CytoplasmicSequence analysis
Transmembranei453 – 47321HelicalSequence analysisAdd
BLAST
Topological domaini474 – 4785ExtracellularSequence analysis
Transmembranei479 – 49921HelicalSequence analysisAdd
BLAST
Topological domaini500 – 55152CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Solute carrier family 22 member 13PRO_0000230783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6A4L0.
PRIDEiQ6A4L0.

PTM databases

iPTMnetiQ6A4L0.
PhosphoSiteiQ6A4L0.

Expressioni

Gene expression databases

BgeeiQ6A4L0.
GenevisibleiQ6A4L0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081855.

Structurei

3D structure databases

ProteinModelPortaliQ6A4L0.
SMRiQ6A4L0. Positions 118-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6A4L0.
KOiK08209.
OMAiSCAWFAT.
OrthoDBiEOG7C8GH9.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFAQVMAE VGDFGRFQVR LTILMGIPNF LAAFFIFGQV FMVLDEAHHC
60 70 80 90 100
SVSWVKNHTF NLSAAEQLAI SIPNDTAGRP ESCLMFRPPP DSASLEDILS
110 120 130 140 150
HRFNETQACD SGWDYPENRP QSLKKEFDLV CDRKNLKKTS QSVFMAGLLV
160 170 180 190 200
GALVFGPVCD WIGRRPSLLM QVLLSGITSM ATAFVSSFEL YLALRFVLAT
210 220 230 240 250
ANAGFLLSTN VLISEWVGPS WRTQAVVLAQ SNVALGQMVL AGLAYGVRNW
260 270 280 290 300
RLLQITGTAP VLLLFFYFWV LPESPRWLLS QGRTEEAKQL VQKAALVNGR
310 320 330 340 350
PLSPELLNQL VPEKTGPSGN ALDLFRHPHL RKVTLILIAV WFVDSLVYYS
360 370 380 390 400
LSFQVGDFGL DIYVTQLIFG AVEMPGRFLS VLMMEKLGRK WSQLCTLTLA
410 420 430 440 450
GIMYIIIIFI PGDLPTVVTV LAVVGKFASA AAFTISYVYT AELFPTIIRQ
460 470 480 490 500
TGMGLVSIFS RVGGIITPLV MLLEQYHQAI PMVIFGSLPI GAGLLCALLP
510 520 530 540 550
ETRGQTLKDT LQDLEQGLPA GSHKTAPQRQ DMEALGRTSS VRVAVVKSSY

F
Length:551
Mass (Da):60,724
Last modified:July 27, 2011 - v3
Checksum:i2DAAE51ED8352724
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti402 – 4021I → V in AAQ09528 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771A → T in strain: FVB/N. 1 Publication
Natural varianti506 – 5061T → I in strain: FVB/N. 1 Publication
Natural varianti535 – 5351L → S in strain: FVB/N. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529220 mRNA. Translation: AAQ09528.1.
AC055818 Genomic DNA. No translation available.
BC021449 mRNA. Translation: AAH21449.1.
CCDSiCCDS40802.1.
RefSeqiNP_598741.2. NM_133980.3.
UniGeneiMm.38775.

Genome annotation databases

EnsembliENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028.
GeneIDi102570.
KEGGimmu:102570.
UCSCiuc009sal.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529220 mRNA. Translation: AAQ09528.1.
AC055818 Genomic DNA. No translation available.
BC021449 mRNA. Translation: AAH21449.1.
CCDSiCCDS40802.1.
RefSeqiNP_598741.2. NM_133980.3.
UniGeneiMm.38775.

3D structure databases

ProteinModelPortaliQ6A4L0.
SMRiQ6A4L0. Positions 118-515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081855.

PTM databases

iPTMnetiQ6A4L0.
PhosphoSiteiQ6A4L0.

Proteomic databases

PaxDbiQ6A4L0.
PRIDEiQ6A4L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028.
GeneIDi102570.
KEGGimmu:102570.
UCSCiuc009sal.2. mouse.

Organism-specific databases

CTDi9390.
MGIiMGI:2143107. Slc22a13.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ6A4L0.
KOiK08209.
OMAiSCAWFAT.
OrthoDBiEOG7C8GH9.
TreeFamiTF315847.

Miscellaneous databases

NextBioi355536.
PROiQ6A4L0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6A4L0.
GenevisibleiQ6A4L0. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of murine organic cation transporter-like 3 (ORCTL-3)."
    Mount D.B.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-77; ILE-506 AND SER-535.
    Strain: FVB/N.
    Tissue: Kidney.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiS22AD_MOUSE
AccessioniPrimary (citable) accession number: Q6A4L0
Secondary accession number(s): E9QP74, Q8VC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.