Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-10

Gene

IL10

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Gene namesi
Name:IL10Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 175154Interleukin-10Sequence analysisPRO_0000296319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 123By similarity
Disulfide bondi77 ↔ 129By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6A2H4.
PRIDEiQ6A2H4.

Expressioni

Tissue specificityi

Expressed predominantly in bursa of Fabricius and cecal tonsils with low levels in thymus, liver and lung.1 Publication

Developmental stagei

Expression is detected as early as embryonic day 12. Higher expression in spleen of post-hatch chickens than embryos. Gradual increase in expression in the spleen which peaks by day 7 post-hatch.1 Publication

Inductioni

By lipopolysaccharide (LPS) in white blood cells, liver and spleen 3 hours after treatment. Decreases to basal levels 8 hours after treatment. By primary infection with E.acervulina and E.tenella.3 Publications

Gene expression databases

ExpressionAtlasiQ6A2H4. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001310.

Structurei

3D structure databases

ProteinModelPortaliQ6A2H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiQ6A2H4.
KOiK05443.
OMAiPHMLREL.
PhylomeDBiQ6A2H4.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6A2H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTCCQALLL LLAACTLPAH CLEPTCLHFS ELLPARLREL RVKFEEIKDY
60 70 80 90 100
FQSRDDELNI QLLSSELLDE FKGTFGCQSV SEMLRFYTDE VLPRAMQTST
110 120 130 140 150
SHQQSMGDLG NMLLGLKATM RRCHRFFTCE KRSKAIKQIK ETFEKMDENG
160 170
IYKAMGEFDI FINYIEEYLL MRRRK
Length:175
Mass (Da):20,514
Last modified:July 24, 2007 - v2
Checksum:iB0966EBEAFDFB050
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201M → I in CAF21727 (PubMed:15294985).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621614 Genomic DNA. Translation: CAF21727.1.
AJ621254 mRNA. Translation: CAF18432.1.
AY647438 mRNA. No translation available.
RefSeqiNP_001004414.2. NM_001004414.2.
UniGeneiGga.46641.

Genome annotation databases

EnsembliENSGALT00000001312; ENSGALP00000001310; ENSGALG00000000892.
GeneIDi428264.
KEGGigga:428264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621614 Genomic DNA. Translation: CAF21727.1.
AJ621254 mRNA. Translation: CAF18432.1.
AY647438 mRNA. No translation available.
RefSeqiNP_001004414.2. NM_001004414.2.
UniGeneiGga.46641.

3D structure databases

ProteinModelPortaliQ6A2H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001310.

Proteomic databases

PaxDbiQ6A2H4.
PRIDEiQ6A2H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000001312; ENSGALP00000001310; ENSGALG00000000892.
GeneIDi428264.
KEGGigga:428264.

Organism-specific databases

CTDi3586.

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiQ6A2H4.
KOiK05443.
OMAiPHMLREL.
PhylomeDBiQ6A2H4.

Miscellaneous databases

NextBioi20829305.
PROiQ6A2H4.

Gene expression databases

ExpressionAtlasiQ6A2H4. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima."
    Rothwell L., Young J.R., Zoorob R., Whittaker C.A., Hesketh P., Archer A., Smith A.L., Kaiser P.
    J. Immunol. 173:2675-2682(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Cecum1 Publication.
  2. "Annotation of the chicken IL10 gene cluster and effects of lipopolysaccharide stimulation on IL10 gene expression."
    Yilmaz A., Shen S., Adelson D.L., Xavier S., Zhu J.
    Anim. Genet. 36:263-265(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  3. "Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections."
    Hong Y.H., Lillehoj H.S., Lee S.H., Dalloul R.A., Lillehoj E.P.
    Vet. Immunol. Immunopathol. 114:209-223(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens."
    Hong Y.H., Lillehoj H.S., Lillehoj E.P., Lee S.H.
    Vet. Immunol. Immunopathol. 114:259-272(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Ontogeny of cytokine gene expression in the chicken spleen."
    Abdul-Careem M.F., Hunter D.B., Lambourne M.D., Barta J., Sharif S.
    Poult. Sci. 86:1351-1355(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiIL10_CHICK
AccessioniPrimary (citable) accession number: Q6A2H4
Secondary accession number(s): Q6A2H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 11, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Chickens susceptible to E.maxima infection show higher constitutive and post-infection levels in spleen and higher post-infection levels in small intestine than infection-resistant animals.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.