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Protein

Interleukin-10

Gene

IL10

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity1 Publication

Miscellaneous

Chickens susceptible to E.maxima infection show higher constitutive and post-infection levels in spleen and higher post-infection levels in small intestine than infection-resistant animals.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-GGA-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Gene namesi
Name:IL10Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000029631922 – 175Interleukin-10Sequence analysisAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 123By similarity
Disulfide bondi77 ↔ 129By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6A2H4

Expressioni

Tissue specificityi

Expressed predominantly in bursa of Fabricius and cecal tonsils with low levels in thymus, liver and lung.1 Publication

Developmental stagei

Expression is detected as early as embryonic day 12. Higher expression in spleen of post-hatch chickens than embryos. Gradual increase in expression in the spleen which peaks by day 7 post-hatch.1 Publication

Inductioni

By lipopolysaccharide (LPS) in white blood cells, liver and spleen 3 hours after treatment. Decreases to basal levels 8 hours after treatment. By primary infection with E.acervulina and E.tenella.3 Publications

Gene expression databases

BgeeiENSGALG00000000892
ExpressionAtlasiQ6A2H4 baseline and differential

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001310

Structurei

3D structure databases

ProteinModelPortaliQ6A2H4
SMRiQ6A2H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW Eukaryota
ENOG4111PXC LUCA
GeneTreeiENSGT00510000048535
HOGENOMiHOG000072692
HOVERGENiHBG004110
InParanoidiQ6A2H4
KOiK05443
OMAiPHMLREL
OrthoDBiEOG091G0Y3M
PhylomeDBiQ6A2H4

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000098 IL-10
IPR020443 IL-10/19/20/22/24/26_fam
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01294 INTRLEUKIN10
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6A2H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTCCQALLL LLAACTLPAH CLEPTCLHFS ELLPARLREL RVKFEEIKDY
60 70 80 90 100
FQSRDDELNI QLLSSELLDE FKGTFGCQSV SEMLRFYTDE VLPRAMQTST
110 120 130 140 150
SHQQSMGDLG NMLLGLKATM RRCHRFFTCE KRSKAIKQIK ETFEKMDENG
160 170
IYKAMGEFDI FINYIEEYLL MRRRK
Length:175
Mass (Da):20,514
Last modified:July 24, 2007 - v2
Checksum:iB0966EBEAFDFB050
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120M → I in CAF21727 (PubMed:15294985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621614 Genomic DNA Translation: CAF21727.1
AJ621254 mRNA Translation: CAF18432.1
AY647438 mRNA No translation available.
RefSeqiNP_001004414.2, NM_001004414.2
UniGeneiGga.46641

Genome annotation databases

EnsembliENSGALT00000001312; ENSGALP00000001310; ENSGALG00000000892
GeneIDi428264
KEGGigga:428264

Similar proteinsi

Entry informationi

Entry nameiIL10_CHICK
AccessioniPrimary (citable) accession number: Q6A2H4
Secondary accession number(s): Q6A2H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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