ID   SSDH_PONPY              Reviewed;         535 AA.
AC   Q6A2H2; Q6A2H3;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   16-JUN-2009, entry version 34.
DE   RecName: Full=Succinate-semialdehyde dehydrogenase, mitochondrial;
DE            EC=1.2.1.24;
DE   AltName: Full=NAD(+)-dependent succinic semialdehyde dehydrogenase;
DE   AltName: Full=Aldehyde dehydrogenase family 5 member A1;
DE   Flags: Precursor;
GN   Name=ALDH5A1;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-10.
RA   Blasi P., Malaspina P.;
RT   "Comparative analysis of succinic semialdehyde dehydrogenase in non
RT   three ape species.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(+) + H(2)O =
CC       succinate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AJ621749; CAF21866.1; -; mRNA.
DR   EMBL; AJ621750; CAF21867.1; -; mRNA.
DR   HOVERGEN; Q6A2H2; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005625; C:soluble fraction; ISS:UniProtKB.
DR   GO; GO:0004777; F:succinate-semialdehyde dehydrogenase activity; ISS:UniProtKB.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; ISS:UniProtKB.
DR   GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR010102; Succ_semiAld_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01780; SSADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; NAD; Oxidoreductase; Polymorphism; Transit peptide.
FT   TRANSIT       1     47       Mitochondrion (Potential).
FT   CHAIN        48    535       Succinate-semialdehyde dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000007187.
FT   NP_BIND     284    289       NADP (By similarity).
FT   ACT_SITE    306    306       Proton acceptor (By similarity).
FT   ACT_SITE    340    340       Nucleophile (By similarity).
FT   SITE        205    205       Transition state stabilizer (By
FT                                similarity).
FT   VARIANT      10     10       S -> C.
FT                                /FTId=VAR_019705.
SQ   SEQUENCE   535 AA;  57109 MW;  A324B14F4BC694F3 CRC64;
     MATCFWLRSS GAQRLGSTFP GCRLRPRAGG LVPASRPAPG PAQLRGYAGG LAGLSAALLR
     TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC SWREVSAKER
     SSLLRKWYXL MIXNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIY
     TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL
     AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV
     KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF
     AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATIVTGG KRHQLGKNFF
     EPTLLCNVTQ DMLCTHEETF GPLAPVIKFN TEEEAIAIAN AADVGLAGYF YSQDPAQIWR
     VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
//