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Reviewed, UniProtKB/Swiss-Prot Q6A2H1 (SSDH_GORGO)

Last modified November 25, 2008. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Succinate-semialdehyde dehydrogenase, mitochondrial
    EC=1.2.1.24
Alternative name(s):
    NAD(+)-dependent succinic semialdehyde dehydrogenase
    Aldehyde dehydrogenase family 5 member A1
Gene names
Name: ALDH5A1
OrganismGorilla gorilla gorilla (Lowland gorilla)
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.

Pathway

Amino-acid degradation; 4-aminobutanoate degradation.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4747Mitochondrion Potential
Chain48 – 535488Succinate-semialdehyde dehydrogenase, mitochondrial
PRO_0000007183

Regions

Nucleotide binding284 – 2896NADP By similarity

Sites

Active site3061Proton acceptor By similarity
Active site3401Nucleophile By similarity
Site2051Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6A2H1-1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: B1FC5E4E92149214

FASTA53557,142
        10         20         30         40         50         60 
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGG LAGLSAALLR 

        70         80         90        100        110        120 
TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKER 

       130        140        150        160        170        180 
SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIY 

       190        200        210        220        230        240 
TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL 

       250        260        270        280        290        300 
AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV 

       310        320        330        340        350        360 
KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF 

       370        380        390        400        410        420 
AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF 

       430        440        450        460        470        480 
EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR 

       490        500        510        520        530 
VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL 

« Hide

References

[1]"Comparative analysis of succinic semialdehyde dehydrogenase in non three ape species."
Blasi P., Malaspina P.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

AJ621751 mRNA. Translation: CAF21868.1.

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENQ6A2H1.

Family and domain databases

InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR010102. Succ_semiAld_DHase.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01780. SSADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSDH_GORGO
AccessionPrimary (citable) accession number: Q6A2H1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 13, 2004
Last modified: November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents